Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 137, Issue 2, Pages 507-+Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2015.08.016
Keywords
Food allergy; Bifidobacterium longum; probiotics; extracellular vesicle; mast cells; family 5 extracellular solute-binding protein; ovalbumin
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Funding
- Institute for Basic Science (IBS) [IBS-R005-S1-2015-a00, IBS-R005-D1-2015-a00]
- National Institute of Animal Science research project of Rural Development Administration of Korea [PJ00932901]
- National Research Foundation of Korea (NRF) [2013-056085]
- Ministry of Science, ICT & Future Planning, Republic of Korea [IBS-R005-D1-2015-A00, IBS-R005-D1-2016-A00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Rural Development Administration (RDA), Republic of Korea [PJ009329012015] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Background: The incidence of food allergies has increased dramatically during the last decade. Recently, probiotics have been studied for the prevention and treatment of allergic disease. Objective: We examined whether Bifidobacterium longum KACC 91563 and Enterococcus faecalis KACC 91532 have the capacity to suppress food allergies. Methods: B longum KACC 91563 and E faecalis KACC 91532 were administered to BALB/c wild-type mice, in which food allergy was induced by using ovalbumin and alum. Food allergy symptoms and various immune responses were assessed. Results: B longum KACC 91563, but not E faecalis KACC 91532, alleviated food allergy symptoms. Extracellular vesicles of B longum KACC 91563 bound specifically tomast cells and induced apoptosis without affecting T-cell immune responses. Furthermore, injection of family 5 extracellular solute-binding protein, a main component of extracellular vesicles, into micemarkedly reduced the occurrence of diarrhea in a mouse food allergy model. Conclusion: B longum KACC 91563 induces apoptosis of mast cells specifically and alleviates food allergy symptoms. Accordingly, B longum KACC 91563 and family 5 extracellular solute-binding protein exhibit potential as therapeutic approaches for food allergies.
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