Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1673, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2022.463129
Keywords
Solid phase microextraction; Carbon fiber; PPF-1; Non-steroidal anti-inflammatory drugs; Electrochemical deposition
Funding
- National Natural Science Foundation of China [82073808, 81872828, 81573384]
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Electrochemical deposition is a promising approach for in situ immobilization of metal-organic framework (MOF) on conductive surfaces, which can be applied to fiber in-tube solid phase microextraction. In this study, PPF-1 was immobilized on carbon fibers by electrochemical method and successfully applied for the quantitative analysis of non-steroidal anti-inflammatory drugs.
Electrochemical deposition has been proposed as a promising approach for in situ immobilization of metal-organic framework (MOF) on conductive surfaces. It is favorable as it is time-saving, green, and does not require vigorous reaction conditions, which can be applied to the synthesis and immobilization of extraction materials for fiber in-tube solid phase microextraction. In this work, PPF-1 was immobilized on the surface of the carbon fibers by electrochemical method. The novel method overcame the problems including strict conditions and time-consuming operation. The modified carbon fibers were packed into the PEEK tube for extraction and analysis of three non-steroidal anti-inflammatory drugs (NSAIDs), which performed good extraction efficiency due to strong hydrogen bonding, hydrophobic interaction and pi-pi interaction between PPF-1 and analytes. The established method obtained good enrichment performance (enrichment factor between 230-540), low limits of detection (between 0.01-0.03 ng/mL), good linearity and good reproducibility (RSDs <= 4.93%), which was successfully applied for the quantitative analysis of NSAIDs in human plasma samples. (C) 2022 Published by Elsevier B.V.
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