Journal
JOURNAL OF CHEMICAL AND ENGINEERING DATA
Volume 67, Issue 6, Pages 1588-1595Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jced.2c00210
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The solubility of 2-aminopyridine in 13 neat solvents was determined and fitted using several models. The mixing characteristics and excess enthalpy were calculated, and the interactions between solute-solvent and solvent-solvent were analyzed.
The solubility data of 2-aminopyridine in 13 neat solvents were determined using the shake-flask method, including methanol, N,N-dimethylformamide (DMF), n-propanol, isopropanol, ethanol, n-butanol, N-methyl-2-pyrrolidine (NMP), isobutanol, n-hexane, cyclohexane, acetonitrile, amyl acetate, and n-propyl acetate. The mole fractions of 2-aminopyridine in equilibrium liquid phase rose with the increase in temperature and followed the decreasing order in different solvents: NMP > DMF > methanol > ethanol > n-propanol > n-butanol > n-propyl acetate > amyl acetate > isopropanol > isobutanol > acetonitrile > n-hexane > cyclohexane. The lambda h equation, NRTL model, modified Apelblat equation, and Wilson model were used to fit them. The greatest root-mean-square deviation value and relative average deviation value obtained were 160.4 x 10(-4) and 4.46 x 10(-2), respectively. For a given solvent, the modified Apelblat equation produced lower relative average deviation values than the other equations. The mixing characteristics, infinitesimal concentration activity coefficient, and reduced excess enthalpy were also calculated. Furthermore, the degree and type of interactions of solute-solvent and solvent-solvent were identified utilizing the relationship analysis of Kamlet and Taft linear solvation energy of solvent effect.
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