Related references
Note: Only part of the references are listed.GPR68 Improves Nerve Damage and Myelination in an Immature Rat Model Induced by Sevoflurane Anesthesia by Activating cAMP/CREB to Mediate BDNF
Dan Zhao et al.
ACS CHEMICAL NEUROSCIENCE (2022)
Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain
Maksim Storozhuk et al.
CURRENT NEUROPHARMACOLOGY (2021)
GPCRdb in 2021: integrating GPCR sequence, structure and function
Albert J. Kooistra et al.
NUCLEIC ACIDS RESEARCH (2021)
Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis
James Osei-Owusu et al.
CELL REPORTS (2021)
Cryo-EM structure of a proton-activated chloride channel TMEM206
Zengqin Deng et al.
SCIENCE ADVANCES (2021)
RNA-Seq analysis of knocking out the neuroprotective proton-sensitive GPR68 on basal and acute ischemia-induced transcriptome changes and signaling in mouse brain
Guokun Zhou et al.
FASEB JOURNAL (2021)
Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 2: Functional and Molecular Properties of ASOR/PAC Channels and Their Roles in Cell Volume Dysregulation and Acidotoxic Cell Death
Yasunobu Okada et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
The evolution and mechanism of GPCR proton sensing
Jacob B. Rowe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2021)
A molecular view of the function and pharmacology of acid-sensing ion channels
Sabrina Vullo et al.
PHARMACOLOGICAL RESEARCH (2020)
Roles of glial ion transporters in brain diseases
Shanshan Song et al.
GLIA (2020)
PAC proton-activated chloride channel contributes to acid-induced cell death in primary rat cortical neurons
James Osei-Owusu et al.
CHANNELS (2020)
Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice
Jan Wenzel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis
Jing-Jing Wang et al.
NATURE COMMUNICATIONS (2020)
Differential Roles of Extracellular Histidine Residues of GPR68 for Proton-Sensing and Allosteric Modulation by Divalent Metal Ions
Xi-Ping Huang et al.
BIOCHEMISTRY (2020)
GPR4 Knockout Improves the Neurotoxin-Induced, Caspase-Dependent Mitochondrial Apoptosis of the Dopaminergic Neuronal Cell
Md Ezazul Haque et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia
Tao Wang et al.
STROKE (2020)
The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model
Koichi Sato et al.
SCIENTIFIC REPORTS (2020)
GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior
Yuanyuan Xu et al.
MOLECULAR BRAIN (2020)
Structures and pH-sensing mechanism of the proton-activated chloride channel
Zheng Ruan et al.
NATURE (2020)
The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells
Elizabeth A. Krewson et al.
ISCIENCE (2020)
Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model
Edward J. Sanderlin et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2019)
GPR68: An Emerging Drug Target in Cancer
Shu Z. Wiley et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel
Junhua Yang et al.
SCIENCE (2019)
Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels
Florian Ullrich et al.
ELIFE (2019)
Acid-Sensing Ion Channels Novel Mediators of Cerebral Vascular Responses
Frank M. Faraci et al.
CIRCULATION RESEARCH (2019)
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors
Simon R. Foster et al.
CELL (2019)
Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain
Chu-Ting Chang et al.
FRONTIERS IN NEUROSCIENCE (2019)
GPR65 inhibits experimental autoimmune encephalomyelitis through CD4+ T cell independent mechanisms that include effects on iNKT cells
Rushika C. Wirasinha et al.
IMMUNOLOGY AND CELL BIOLOGY (2018)
The Proton-activated Receptor GPR4 Modulates Intestinal Inflammation
Yu Wang et al.
JOURNAL OF CROHNS & COLITIS (2018)
GPCRdb in 2018: adding GPCR structure models and ligands
Gaspar Pandy-Szekeres et al.
NUCLEIC ACIDS RESEARCH (2018)
NGL viewer: web-based molecular graphics for large complexes
Alexander S. Rose et al.
BIOINFORMATICS (2018)
GPR68 Senses Flow and Is Essential for Vascular Physiology
Jie Xu et al.
CELL (2018)
Lactate in the brain: from metabolic end-product to signalling molecule
Pierre J. Magistretti et al.
NATURE REVIEWS NEUROSCIENCE (2018)
CNS distribution, signalling properties and central effects of G-protein coupled receptor 4
P. S. Hosford et al.
NEUROPHARMACOLOGY (2018)
Coincidence Detection of Membrane Stretch and Extracellular pH by the Proton-Sensing Receptor OGR1 (GPR68)
Wei-Chun Wei et al.
CURRENT BIOLOGY (2018)
Region specific contribution of ASIC2 to acidosis-and ischemia-induced neuronal injury
Nan Jiang et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2017)
Proton-sensing G protein-coupled receptors as regulators of cell proliferation and migration during tumor growth and wound healing
Katharina T. Weiss et al.
EXPERIMENTAL DERMATOLOGY (2017)
TDAG8 activation attenuates cerebral ischaemia-reperfusion injury via Akt signalling in rats
X. D. Ma et al.
EXPERIMENTAL NEUROLOGY (2017)
Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells
Lixue Dong et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis
Juraj Velcicky et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a
Irene R. Chassagnon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
The proton-sensing G protein-coupled receptor T-cell deathassociated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction
Akiomi Nagasaka et al.
SCIENTIFIC REPORTS (2017)
Microglial Acid Sensing Regulates Carbon Dioxide-Evoked Fear
Lauren Larke Vollmer et al.
BIOLOGICAL PSYCHIATRY (2016)
Proton detection and breathing regulation by the retrotrapezoid nucleus
Patrice G. Guyenet et al.
JOURNAL OF PHYSIOLOGY-LONDON (2016)
Increased bone density in mice lacking the proton receptor OGR1
Nancy S. Krieger et al.
KIDNEY INTERNATIONAL (2016)
Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction
Hayato Fukuda et al.
ACS MEDICINAL CHEMISTRY LETTERS (2016)
Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors
Shing-Hong Lin et al.
NATURE COMMUNICATIONS (2016)
Functional analysis of acid-activated Cl- channels: Properties and mechanisms of regulation
Valeria Capurro et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2015)
Vagal Sensory Neuron Subtypes that Differentially Control Breathing
Rui B. Chang et al.
CELL (2015)
GPR4 decreases B16F10 melanoma cell spreading and regulates focal adhesion dynamics through the G13/Rho signaling pathway
Calvin R. Justus et al.
EXPERIMENTAL CELL RESEARCH (2015)
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
Xi-Ping Huang et al.
NATURE (2015)
Neural Control of Breathing and CO2 Homeostasis
Patrice G. Guyenet et al.
NEURON (2015)
Biophysical properties of acid-sensing ion channels (ASICs)
Stefan Gruender et al.
NEUROPHARMACOLOGY (2015)
INCREASED EXPRESSION OF THE PROTON-SENSING G PROTEIN-COUPLED RECEPTOR Gpr65 DURING RETINAL DEGENERATION
D. Ail et al.
NEUROSCIENCE (2015)
Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H+
Wei-Chun Wei et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons
Natasha N. Kumar et al.
SCIENCE (2015)
Changes of pH and Energy State in Subacute Human Ischemia Assessed by Multinuclear Magnetic Resonance Spectroscopy
Johann Philipp Zoellner et al.
STROKE (2015)
Acidic pH increases cGMP accumulation through the OGR1/phospholipase C/Ca2+/neuronal NOS pathway in N1E-115 neuronal cells
Mie Kotake et al.
CELLULAR SIGNALLING (2014)
Temperature sensitivity of acid-sensitive outwardly rectifying (ASOR) anion channels in cortical neurons is involved in hypothermic neuroprotection against acidotoxic necrosis
Kaori Sato-Numata et al.
CHANNELS (2014)
Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity
Collin J. Kreple et al.
NATURE NEUROSCIENCE (2014)
Regulation of inflammation by extracellular acidification and proton-sensing GPCRs
Fumikazu Okajima
CELLULAR SIGNALLING (2013)
Acid-Sensing Ion Channel-1a Is Not Required for Normal Hippocampal LTP and Spatial Memory
Pu-Yeh Wu et al.
JOURNAL OF NEUROSCIENCE (2013)
Acid-sensing ion channels in pain and disease
John A. Wemmie et al.
NATURE REVIEWS NEUROSCIENCE (2013)
Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis
Lixue Dong et al.
PLOS ONE (2013)
Proton-Sensing Ovarian Cancer G Protein-Coupled Receptor 1 on Dendritic Cells Is Required for Airway Responses in a Murine Asthma Model
Haruka Aoki et al.
PLOS ONE (2013)
Acid-sensitive outwardly rectifying (ASOR) anion channels in human epithelial cells are highly sensitive to temperature and independent of ClC-3
Kaori Sato-Numata et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2013)
Acid-sensing ion channels: trafficking and synaptic function
Xiang-ming Zha
MOLECULAR BRAIN (2013)
Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
Calvin R. Justus et al.
FRONTIERS IN PHYSIOLOGY (2013)
The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH
H. Saxena et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
The Proton-activated G Protein Coupled Receptor OGR1 Acutely Regulates the Activity of Epithelial Proton Transport Proteins
Nilufar Mohebbi et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2012)
Molecular Mechanisms of Acid-Base Sensing by the Kidney
Dennis Brown et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)
Black mamba venom peptides target acid-sensing ion channels to abolish pain
Sylvie Diochot et al.
NATURE (2012)
Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1
Roger J. P. Dawson et al.
NATURE COMMUNICATIONS (2012)
Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor
Lorenza Wyder et al.
ANGIOGENESIS (2011)
The neuroprotective effects of NMDAR antagonist, ifenprodil and ASIC1a inhibitor, flurbiprofen on post-ischemic cerebral injury
Vikas Mishra et al.
BRAIN RESEARCH (2011)
Expressing acid-sensing ion channel 3 in the brain alters acid-evoked currents and impairs fear conditioning
V. C. Vralsted et al.
GENES BRAIN AND BEHAVIOR (2011)
Heteromeric Acid-Sensing Ion Channels (ASICs) Composed of ASIC2b and ASIC1a Display Novel Channel Properties and Contribute to Acidosis-Induced Neuronal Death
Thomas W. Sherwood et al.
JOURNAL OF NEUROSCIENCE (2011)
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
Christopher J. Bohlen et al.
NATURE (2011)
Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway
Aishe Chen et al.
PLOS ONE (2011)
Extracellular acidification stimulates IL-6 production and Ca2+ mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells
Isao Ichimonji et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2010)
A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel
Ye Yu et al.
NEURON (2010)
Diarylamidines: High potency inhibitors of acid-sensing ion channels
Xuanmao Chen et al.
NEUROPHARMACOLOGY (2010)
Acid-sensing by the T cell death-associated gene 8 (TDAG8) receptor cloned from rat brain
Jennifer McGuire et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Effects of cerebral ischemia on neuronal hemoglobin
Yangdong He et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2009)
Involvement of Proton-Sensing TDAG8 in Extracellular Acidification-Induced Inhibition of Proinflammatory Cytokine Production in Peritoneal Macrophages
Chihiro Mogi et al.
JOURNAL OF IMMUNOLOGY (2009)
Dynorphin Opioid Peptides Enhance Acid-Sensing Ion Channel 1a Activity and Acidosis-Induced Neuronal Death
Thomas W. Sherwood et al.
JOURNAL OF NEUROSCIENCE (2009)
ASIC2 Subunits Target Acid-Sensing Ion Channels to the Synapse via an Association with PSD-95
Xiang-ming Zha et al.
JOURNAL OF NEUROSCIENCE (2009)
The role of CAMKIIα in neuropathic pain
Y. Chen et al.
JOURNAL OF PAIN (2009)
Abnormalities in Osteoclastogenesis and Decreased Tumorigenesis in Mice Deficient for Ovarian Cancer G Protein-Coupled Receptor 1
Hui Li et al.
PLOS ONE (2009)
Extracellular acidification enhances osteoclast survival through an NFAT-independent, protein kinase C-dependent pathway
Alexey Pereverzev et al.
BONE (2008)
Extracellular acidification elicits spatially and temporally distinct Ca2+ signals
Wan-Chen Huang et al.
CURRENT BIOLOGY (2008)
Cyclooxygenase-2 expression and prostaglandin E2 production in response to acidic pH through OGR1 in a human osteoblastic cell line
Hideaki Tomura et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2008)
Bioenergetics of cerebral ischemia: A cellular perspective
Leif Hertz
NEUROPHARMACOLOGY (2008)
Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness the stomach-brainstem axis
Thomas Wultsch et al.
PAIN (2008)
Nociceptors of dorsal root ganglion express proton-sensing G-protein-coupled receptors
Chia-Wei Huang et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2007)
Structure of acid-sensing ion channel 1 at 1.9A resolution and low pH
Jayasankar Jasti et al.
NATURE (2007)
Previously postulated ligand-independent signaling of GPR4 is mediated through proton-sensing mechanisms
Masayuki Tobo et al.
CELLULAR SIGNALLING (2007)
Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor
Li V. Yang et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Acid sensing ion channels - novel therapeutic targets for ischemic brain injury
Zhi-Gang Xiong et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2007)
Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia
Giuseppe Pignataro et al.
BRAIN (2007)
A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration
Fei Huang et al.
ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH (2007)
Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: A novel type of multi-functional receptors
H Tomura et al.
CELLULAR SIGNALLING (2005)
Prostaglandin I2 production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells
H Tomura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Identification of T cell death-associated gene 8 ( TDAG8) as a novel acid sensing G-protein-coupled receptor
S Ishii et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells
CG Radu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons
S Diochot et al.
EMBO JOURNAL (2004)
Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior
JA Wemmie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration
M Ettaiche et al.
JOURNAL OF NEUROSCIENCE (2004)
TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor
JQ Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine
N Murakami et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels
XP Chu et al.
JOURNAL OF NEUROSCIENCE (2004)
Regulation and modulation of pH in the brain
M Chesler
PHYSIOLOGICAL REVIEWS (2003)
Proton-sensing G-protein-coupled receptors
MG Ludwig et al.
NATURE (2003)
Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability
E Deval et al.
NEUROPHARMACOLOGY (2003)
Neuroglobin protects the brain from experimental stroke in vivo
YJ Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1)
E Babini et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory
JA Wemmie et al.
NEURON (2002)
A role for CO2 and bicarbonate transporters in metabolic exchanges in the brain
JW Deitmer
JOURNAL OF NEUROCHEMISTRY (2002)
The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice
MP Price et al.
NEURON (2001)
Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons
DC Immke et al.
NATURE NEUROSCIENCE (2001)
The mammalian sodium channel BNC1 is required for normal touch sensation
MP Price et al.
NATURE (2000)
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels
P Escoubas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)