Supported palladium-catalyzed carbonylative cyclization of 2-bromonitrobenzenes and alkynes to access quinolin-4(1H)-ones

A palladium supported on graphitic carbon nitride (Pd/g-C3N4) catalyzed carbonylative cyclization of 2-bromonitrobenzenes and alkynes has been developed for the expedite construction of quinolin-4(1H)-one scaffolds. By using a low loading heterogeneous palladium catalyst, Mo(CO)(6) as both the CO surrogate and the reductant, and nitroarenes as the nitrogen source, the reaction proceeded well to give a variety of quinolin-4(1H)-ones in good to excellent yields. (C)& nbsp;2022 Elsevier Inc. All rights reserved.

Automated summary

A carbonylative cyclization of 2-bromonitrobenzenes and alkynes catalyzed by palladium supported on graphitic carbon nitride (Pd/g-C3N4) has been developed for the efficient construction of quinolin-4(1H)-one scaffolds using Mo(CO)(6) as the CO surrogate and reductant, and nitroarenes as the nitrogen source.