☆ 4.1 Article

Two-stage designs with small sample sizes

JOURNAL OF BIOPHARMACEUTICAL STATISTICS (2023)

Related references

Note: Only part of the references are listed.

Article Mathematical & Computational Biology

Optimal planning of adaptive two-stage designs

Maximilian Pilz et al.

Summary: The study demonstrates that optimal adaptive designs can bring significant benefits in clinical trial planning. By customizing the underlying optimization problem, optimal designs can be tailored to specific operational requirements for an almost negligible performance loss compared to conventional designs.

STATISTICS IN MEDICINE (2021)

Add to Collection

Article Computer Science, Interdisciplinary Applications

The adoptr Package: Adaptive Optimal Designs for Clinical Trials in R

Kevin Kunzmann et al.

Summary: Adoptr is a statistical software for adaptive two-stage trial designs, particularly for two-arm trials with normally distributed outcomes. Unlike previous approaches, adoptr optimizes the design upfront, aiming for maximum efficiency. It allows users to specify different objective functions flexibly, and provides measures to assist practitioners in the validation process.

JOURNAL OF STATISTICAL SOFTWARE (2021)

Add to Collection

Article Health Care Sciences & Services