Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Volume 110, Issue 8, Pages 1956-1967Publisher
WILEY
DOI: 10.1002/jbm.b.35053
Keywords
bio-membrane mimetic; hemoperfusion adsorbent; hyperlipidaemia; low-density lipoprotein
Funding
- National Key Research and Development Program of China [2017YFC1104401]
- National Natural Science Foundation of China [81771986, 82172093]
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A biomembrane-mimetic LDL adsorbent has been developed, which can effectively remove LDL and total cholesterol while maintaining high-density lipoprotein within the normal range. The adsorbent also exhibits excellent blood compatibility and anticoagulant properties, making it a promising treatment option for hyperlipidaemia.
Lowering of low-density lipoprotein (LDL) levels in blood of patients with hyperlipidaemia can effectively prevent the progression of atherosclerosis and coronary heart disease. The present study demonstrated a facile synthesis strategy to prepare biomembrane-mimetic LDL adsorbent (PVA@COOH-PE) via directional immobilization of phospholipid onto macro-porous cross-linked poly(vinyl alcohol) spheres. The binding between the prepared adsorbent and LDL particles simulates the cytosolic lipid droplets to form a lipid-packing structure. The adsorbent possesses satisfactory removal efficiency for LDL and total cholesterol (TCH) in hyperlipemia serum, while remains high-density lipoprotein (HDL) concentration within the normal range. The adsorption capacities for LDL and TCH are about 1.13 and 1.74 mg/ml respectively, which are nearly three and four times higher than that of HDL (0.42 mg/ml). The adsorbent also possesses satisfactory anticoagulant properties, causes negligible effect on blood cells and produces low hemolysis ratios. The excellent blood compatibility plus LDL removal efficiency of PVA@COOH-PE indicates its good application prospect as hemoperfusion adsorbent in the treatment of hyperlipidaemia.
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