4.6 Article

The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity

Related references

Note: Only part of the references are listed.
Article Virology

Phenotypical Characterization of the Nuclear Egress of Recombinant Cytomegaloviruses Reveals Defective Replication upon ORF-UL50 Deletion but Not pUL50 Phosphosite Mutation

Sigrun Haege et al.

Summary: Research has shown that pUL50 plays a crucial role in nuclear egress of human cytomegalovirus (HCMV), but mutations in phosphorylation sites of pUL50 have minimal impact on the virus's replication capabilities.

VIRUSES-BASEL (2021)

Article Virology

Properties of Oligomeric Interaction of the Cytomegalovirus Core Nuclear Egress Complex (NEC) and Its Sensitivity to an NEC Inhibitory Small Molecule

Jintawee Kicuntod et al.

Summary: This study investigates the oligomeric interaction of HCMV core NEC and the antiviral activity of targeted inhibitors, suggesting the oligomeric binding pattern and drug-accessible complex as validated antiviral drug targets. The research provides insights into the formation of HCMV core NEC and the potential for developing new antiviral strategies.

VIRUSES-BASEL (2021)

Review Virology

HCMV Antivirals and Strategies to Target the Latent Reservoir

Marianne R. Perera et al.

Summary: HCMV can establish lifelong latency in healthy individuals and cause severe disease in immunosuppressed patients. Current antiviral drugs face challenges of poor bioavailability, toxicity, viral resistance, and inability to fully target latent infection. Treatments targeting latent infection are needed to address disease caused by reactivation from latency.

VIRUSES-BASEL (2021)

Article Multidisciplinary Sciences

A PROSS-designed extensively mutated estrogen receptor α variant displays enhanced thermal stability while retaining native allosteric regulation and structure

Mark Kriegel et al.

Summary: The application of PROSS server algorithms enabled the development of variant ERPRS* with 24 amino acid substitutions, leading to improved production rates, crystallization, and thermal stability. Despite 10% amino acid substitutions, ERPRS* preserved the allosteric regulatory behaviors of nuclear receptors, suggesting promise for developing novel modulators targeting hER alpha.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

DALI and the persistence of protein shape

Liisa Holm

PROTEIN SCIENCE (2020)

Article Microbiology

Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells

Werner J. D. Ouwendijk et al.

FRONTIERS IN MICROBIOLOGY (2020)

Article Biochemical Research Methods

A quantitative nuclear egress assay to investigate the nucleocytoplasmic capsid release of human cytomegalovirus

Sigrun Haege et al.

JOURNAL OF VIROLOGICAL METHODS (2020)

Article Biochemical Research Methods

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

Dorothee Liebschner et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2019)

Review Microbiology

EHV-1: A Constant Threat to the Horse Industry

Fatai S. Oladunni et al.

FRONTIERS IN MICROBIOLOGY (2019)

Article Pharmacology & Pharmacy

New therapies for human cytomegalovirus infections

William J. Britt et al.

ANTIVIRAL RESEARCH (2018)

Article Biochemistry & Molecular Biology

UniProt: the universal protein knowledgebase

Alex Bateman et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Biotechnology & Applied Microbiology

Protein kinases responsible for the phosphorylation of the nuclear egress core complex of human cytomegalovirus

Eric Sonntag et al.

JOURNAL OF GENERAL VIROLOGY (2017)

Article Cell Biology

Getting to and through the inner nuclear membrane during herpesvirus nuclear egress

Ming F. Lye et al.

CURRENT OPINION IN CELL BIOLOGY (2017)

Review Virology

Nuclear Exodus: Herpesviruses Lead the Way

Janna M. Bigalke et al.

ANNUAL REVIEW OF VIROLOGY, VOL 3 (2016)

Review Microbiology

The Role of Gammaherpesviruses in Cancer Pathogenesis

Hem Chandra Jha et al.

PATHOGENS (2016)

Article Biochemistry & Molecular Biology

Structural Basis of Vesicle Formation at the Inner Nuclear Membrane

Christoph Hagen et al.

Article Biochemistry & Molecular Biology

Structural basis of membrane budding by the nuclear egress complex of herpesviruses

Janna M. Bigalke et al.

EMBO JOURNAL (2015)

Article Biochemistry & Molecular Biology

Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex

Ming F. Lye et al.

EMBO JOURNAL (2015)

Article Biochemical Research Methods

Proteomic Analysis of the Multimeric Nuclear Egress Complex of Human Cytomegalovirus

Jens Milbradt et al.

MOLECULAR & CELLULAR PROTEOMICS (2014)

Review Microbiology

Molecular mechanisms of varicella zoster virus pathogenesis

Leigh Zerboni et al.

NATURE REVIEWS MICROBIOLOGY (2014)

Review Veterinary Sciences

Epidemiology and control of bovine herpesvirus 1 infection in Europe

Kerli Raaperi et al.

VETERINARY JOURNAL (2014)

Article Multidisciplinary Sciences

Membrane deformation and scission by the HSV-1 nuclear egress complex

Janna M. Bigalke et al.

NATURE COMMUNICATIONS (2014)

Article Cell Biology

Mouse cytomegalovirus egress protein pM50 interacts with cellular endophilin-A2

Frederic Lemnitzer et al.

CELLULAR MICROBIOLOGY (2013)

Review Cell Biology

The way out: what we know and do not know about herpesvirus nuclear egress

Thomas C. Mettenleiter et al.

CELLULAR MICROBIOLOGY (2013)

Article Biotechnology & Applied Microbiology

The cytomegalovirus egress proteins pUL50 and pUL53 are translocated to the nuclear envelope through two distinct modes of nuclear import

Cathrin Schmeiser et al.

JOURNAL OF GENERAL VIROLOGY (2013)

Article Biochemical Research Methods

Overview of the CCP4 suite and current developments

Martyn D. Winn et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2011)

Review Neurosciences

Synapse-to-nucleus signaling

Toh Hean Ch'ng et al.

CURRENT OPINION IN NEUROBIOLOGY (2011)

Article Biochemical Research Methods

XDS

Wolfgang Kabsch

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Biochemical Research Methods

Features and development of Coot

P. Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Pediatrics

Effects of cytomegalovirus infection on embryogenesis and brain development

Yoshihiro Tsutsui

CONGENITAL ANOMALIES (2009)

Article Biotechnology & Applied Microbiology

Cytomegaloviral proteins that associate with the nuclear lamina: components of a postulated nuclear egress complex

Jens Milbradt et al.

JOURNAL OF GENERAL VIROLOGY (2009)

Article Biotechnology & Applied Microbiology

Mapping of a self-interaction domain of the cytomegalovirus protein kinase pUL97

Vera Schregel et al.

JOURNAL OF GENERAL VIROLOGY (2007)

Article Biochemistry & Molecular Biology

Lysine methylation as a routine rescue strategy for protein crystallization

Thomas S. Walter et al.

STRUCTURE (2006)

Article Biochemistry & Molecular Biology

The FoldX web server: an online force field

J Schymkowitz et al.

NUCLEIC ACIDS RESEARCH (2005)

Review Microbiology

Molecular biololgy of pseudorabies virus: Impact on neurovirology and veterinary medicine

LE Pomeranz et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2005)

Article Biochemical Research Methods

TEXshade:: shading and labeling of multiple sequence alignments using LATEX 2ε

E Beitz

BIOINFORMATICS (2000)