4.5 Article

Gut Microbiota and Subjective Memory Complaints in Older Women

Journal

JOURNAL OF ALZHEIMERS DISEASE
Volume 88, Issue 1, Pages 251-262

Publisher

IOS PRESS
DOI: 10.3233/JAD-220011

Keywords

16S RNA gene sequencing; cross-sectional; gut microbiota; NYUWHS; subjective memory complaints

Categories

Funding

  1. National Institutes of Health [U01 CA182934]

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This cross-sectional study found an association between alterations in gut microbial composition and cognitive dysfunction. Higher relative abundances of genus Holdemania and family Desulfovibrionaceae were observed in women reporting more subjective memory complaints (SMCs). Additionally, a dose-response association was observed for genus Sutterella and family Desulfovibrionaceae with increasing SMCs.
Background: Epidemiological studies that investigate alterations in gut microbial composition associated with cognitive dysfunction are limited. Objective: To examine the association between the gut microbiota and subjective memory complaints (SMCs), a self-reported, validated indicator of cognitive dysfunction. Methods: In this cross-sectional study of 95 older women selected from the New York University Women's Health Study (NYUWHS), we characterized the gut microbial composition using 16S rRNA gene sequencing. We estimated odds ratio (OR) from beta regression which approximates the ratio of mean relative abundances of individual bacterial taxon from phylum to genus levels by binary (2+ versus < 2) and continuous SMCs. Results: Women reporting 2 or more SMCs had higher relative abundances of genus Holdemania and family Desulfovibrionaceae compared with those reporting one or no complaint. Compared with women with < 2 SMCs, the relative abundances of Holdemania and family Desulfovibrionaceae were 2.09 times (OR: 2.09, 95% confidence interval [CI]: 1.38-3.17) and 2.10 times (OR: 2.10, 95% CI: 1.43-3.09) higher in women with 2+ SMCs, respectively (false discovery rate (FDR)-adjusted p = 0.038 and 0.010, respectively). A dose-response association was observed for genus Sutterella and family Desulfovibrionaceae. Every one-unit increase in SMCs was associated with 25% and 27% higher relative abundances of Sutterella (OR: 1.25; 95% CI: 1.11-1.40) and Desulfovibrionaceae (OR: 1.27; 95% CI: 1.13-1.42), respectively (FDR-adjusted p = 0.018 and 0.006, respectively). Conclusion: Our findings support an association between alterations in the gut bacterial composition and cognitive dysfunction.

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