Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 87, Issue 3, Pages 991-997Publisher
IOS PRESS
DOI: 10.3233/JAD-215646
Keywords
Alzheimer's disease; cerebrospinal fluid; phosphorylated-tau; plasma biomarkers
Categories
Funding
- Airalzh-AGYR2020 grant
Ask authors/readers for more resources
Plasma phosphorylated tau species levels are elevated in early stage AD and strongly related to phosphorylated tau, total tau, and amyloid in cerebrospinal fluid. These findings may support the use of plasma markers for diagnosing and prognosing AD in the early stage.
Plasma phosphorylated tau species have been recently proposed as peripheral markers of Alzheimer's disease (AD) pathology. In this cross-sectional study including 91 subjects, plasma and cerebrospinal fluid (CSF) p-tau181 and p-tau231 levels were elevated in the early symptomatic stages of AD. Plasma p-tau231 and p-tau181 were strongly related to CSF phosphorylated tau, total tau and amyloid and exhibited a high accuracy-close to CSF p-tau231 and p-tau181-to identify AD already in the early stage of the disease. The findings might support the use as diagnostic and prognostic peripheral AD biomarkers in both research and clinical settings.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available