Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 70, Issue 18, Pages 5610-5623Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.2c01883
Keywords
circadian rhythm disruption; Pu-erh tea; gut-liver-brain axis; gut microbiota; tryptophan metabolism
Funding
- Chongqing Technology Innovation and Application Demonstration Project - Germplasm Creation Research Program of Southwest University, Chongqing Technology Innovation and Application Development Project [cstc2020jscx-tpyzxX0009, cstc2020jscx-tpyzxX0012]
- Chongqing Science and Technology Bureau [cstc2019jscx-dxwtBX0030]
Ask authors/readers for more resources
This study suggests that Pu-erh tea has the potential to prevent circadian rhythm disorders by promoting pathways of tryptophan metabolism and signaling interactions in the gut-liver-brain axis.
Pu-erh tea is a healthy beverage rich in phytochemicals, and its effect on the risk of inducing circadian rhythm disorders (CRD) is unclear. In this study, healthy mice were given water or 0.25% (w/v) Pu-erh tea for 7 weeks, followed by a 40 day disruption of the light/dark cycle. CRD caused dysregulation of neurotransmitter secretion and clock gene oscillations, intestinal inflammation, and disruption of intestinal microbes and metabolites. Pu-erh tea boosted the indole and 5-hydroxytryptamine pathways of tryptophan metabolism via the gut-liver-brain axis. Furthermore, its metabolites (e.g., IAA, Indole, 5-HT) enhanced hepatic glycolipid metabolism and down-regulated intestinal oxidative stress by improving the brain hormone release. Tryptophan metabolites and bile acids also promoted liver lipid metabolism and inhibited intestinal inflammation (MyD88/NF-Kappa B) via the enterohepatic circulation. Collectively, 0.25% (w/v) Pu-erh tea has the potential to prevent CRD by promoting indole and 5-HT pathways of tryptophan metabolism and signaling interactions in the gut-liver-brain axis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available