Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 70, Issue 23, Pages 7085-7094Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.2c01595
Keywords
data mining tools integration; Pu-erh tea; flavonoids; fermentation
Funding
- Science and Technology Development Fund, Macau SAR [FDCT 0025/2021/A1, 0067/2020/A2]
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This study established a data mining workflow to discover and analyze flavonoids in Pu-erh tea, revealing their dynamic changes during fermentation. It provides a quick and automatic strategy for flavonoid profiling and contributes to the understanding of Pu-erh tea manufacturing and substance foundation research.
Flavonoid represents a significant class of secondary metabolites in Pu-erh tea with benefits to human health. For a rapid and complete discovery of such compounds, we established a data mining workflow that integrates software MS-DIAL, MS-FINDER, and molecular networking analysis. As a result, 181 flavonoids were tentatively annotated including 22 first found in Pu-erh tea, and two of them were potentially new molecules. The dynamic alteration of these flavonoids during Pu-erh fermentation was further investigated. They all showed a trend of first increasing and then decreasing. Moreover, statistical analysis showed that the first to third pile turnings of the fermentation process had a greater impact on the changes of flavonoids. Partial metabolic pathways were proposed. This study provides a quick and automatic strategy for flavonoid profiling. The temporal dimension of flavonoids during fermentation may serve as a theoretical basis for Pu-erh tea manufacturing technology and study on substance foundation.
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