4.7 Article

Punicalagin Attenuates Neuronal Apoptosis by Upregulating 5-Hydroxymethylcytosine in the Diabetic Mouse Brain

Related references

Note: Only part of the references are listed.
Article Environmental Sciences

Gestational arsenic exposure induces anxiety-like behaviors in adult offspring by reducing DNA hydroxymethylation in the developing brain

Jin-Wei Lv et al.

Summary: Research has shown that gestational arsenic exposure can lead to anxiety-like behaviors in adult offspring, possibly by inhibiting DNA hydroxymethylation in the developing brain. Interestingly, ascorbic acid has been found to reverse this effect and attenuate anxiety-like behaviors.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Biochemistry & Molecular Biology

Cytoprotective Effects of Punicalagin on Hydrogen-Peroxide-Mediated Oxidative Stress and Mitochondrial Dysfunction in Retinal Pigment Epithelium Cells

Maria Elisabetta Clementi et al.

Summary: The study indicates that punicalagin (PUN) from pomegranate can effectively protect against mitochondrial dysfunction, reduce oxidative stress, and decrease cellular apoptosis in retinal pigment epithelium (RPE) cells. This suggests that PUN may serve as a beneficial nutraceutical agent in treating oxidation-associated disorders of RPE.

ANTIOXIDANTS (2021)

Article Biochemistry & Molecular Biology

LncRNA MEG3 Alleviates Diabetic Cognitive Impairments by Reducing Mitochondrial-Derived Apoptosis through Promotion of FUNDC1-Related Mitophagy via Rac1-ROS Axis

Zhihua Wang et al.

Summary: The study found that MEG3 was down-regulated in diabetic rats, and overexpression of MEG3 improved cognitive impairments induced by diabetes, affecting pathways and cellular components such as mitochondria and Rac1.

ACS CHEMICAL NEUROSCIENCE (2021)

Article Cell Biology

Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health

Joji Kusuyama et al.

Summary: Poor maternal diet increases the risk of obesity and type 2 diabetes in offspring, while maternal exercise improves their metabolic health. The increase in placenta-derived SOD3 through maternal exercise activates an AMPK/TET signaling axis in the fetal offspring liver, resulting in improved glucose tolerance and liver function. This cross talk between SOD3 and offspring liver provides a central mechanism for enhancing offspring metabolic health.

CELL METABOLISM (2021)

Article Medicine, Research & Experimental

Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1

Yiyuan Zhou et al.

Summary: The study suggests that fumaric acid and succinic acid can treat gestational hypertension by downregulating the expression levels of KCNMB1 and TET1.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Review Endocrinology & Metabolism

Cognitive dysfunction in diabetes: how to implement emerging guidelines

Geert J. Biessels et al.

DIABETOLOGIA (2020)

Article Nutrition & Dietetics

Randomized placebo-controlled study of the memory effects of pomegranate juice in middle-aged and older adults

Prabha Siddarth et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2020)

Article Food Science & Technology

Punicalagin Activates AMPK/PGC-1α/Nrf2 Cascade in Mice: The Potential Protective Effect against Prenatal Stress

Ke Cao et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2020)

Article Biotechnology & Applied Microbiology

A Comparative Study on 5hmC Targeting Regulation of Neurons in AD Mice by Several Natural Compounds

Dongyi Cao et al.

BIOMED RESEARCH INTERNATIONAL (2020)

Article Biochemistry & Molecular Biology

Selective loss of 5hmC promotes neurodegeneration in the mouse model of Alzheimer's disease

Ying Zhang et al.

FASEB JOURNAL (2020)

Article Neurosciences

Understanding the link between insulin resistance and Alzheimer's disease: Insights from animal models

Natalia de M. Lyra e Silva et al.

EXPERIMENTAL NEUROLOGY (2019)

Article Biochemistry & Molecular Biology

Punicalagin attenuates endothelial dysfunction by activating FoxO1, a pivotal regulating switch of mitochondrial biogenesis

Xuyun Liu et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Genetics & Heredity

Phosphorylation of TET2 by AMPK is indispensable in myogenic differentiation

Ting Zhang et al.

EPIGENETICS & CHROMATIN (2019)

Article Multidisciplinary Sciences

Epigenetic signatures of methylated DNA cytosine in Alzheimer's disease

Irfete S. Fetahu et al.

SCIENCE ADVANCES (2019)

Review Endocrinology & Metabolism

Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

Geert Jan Biessels et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

Article Chemistry, Multidisciplinary

Insight into wild-type and T1372E TET2-mediated 5hmC oxidation using ab initio QM/MM calculations

Hedieh Torabifard et al.

CHEMICAL SCIENCE (2018)

Article Biochemistry & Molecular Biology

Multiregional analysis of global 5-methylcytosine and 5-hydroxymethylcytosine throughout the progression of Alzheimer's disease

Elizabeth M. Ellison et al.

JOURNAL OF NEUROCHEMISTRY (2017)

Review Genetics & Heredity

TET-mediated active DNA demethylation: mechanism, function and beyond

Xiaoji Wu et al.

NATURE REVIEWS GENETICS (2017)

Article Integrative & Complementary Medicine

Punicalagin Pretreatment Attenuates Myocardial Ischemia-Reperfusion Injury via Activation of AMPK

Mingge Ding et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2017)

Review Genetics & Heredity

Role of 5-hydroxymethylcytosine in neurodegeneration

Shariq I. Sherwani et al.

Article Biochemistry & Molecular Biology

Mixed Pro- and Anti-Oxidative Effects of Pomegranate Polyphenols in Cultured Cells

Francesca Danesi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Article Food Science & Technology

Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients

Maria A. Nunez-Sanchez et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2014)

Article Endocrinology & Metabolism

Punicalagin, a polyphenol in pomegranate juice, downregulates p53 and attenuates hypoxia-induced apoptosis in cultured human placental syncytiotrophoblasts

Baosheng Chen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)

Article Endocrinology & Metabolism

Pomegranate juice and punicalagin attenuate oxidative stress and apoptosis in human placenta and in human placental trophoblasts

Baosheng Chen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2012)

Article Multidisciplinary Sciences

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

Skirmantas Kriaucionis et al.

SCIENCE (2009)