Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.1c08383
Keywords
trifluoromethylpyridine; biological activity; crop protection; pesticide
Funding
- Natural Science Foundation of China (NSFC) [32072445, 21762012]
- Program of Introducing Talents to Chinese Universities [D20023]
- S&T Planning Project of Guizhou Province [(2017) 5788]
- Graduate Research Fund in Guizhou Province [YJSKYJJ (2021) 038]
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This review summarizes the research progress and design principles of pesticides containing TFMP fragments, aiming to provide a convenient reference for graduate students with educational value.
Trifluoromethylpyridine (TFMP) is a biologically active fragment formed by connecting trifluoromethyl and pyridine ring. As a result of its unique physical and chemical properties and outstanding biological activity, a variety of pesticide compounds with the TFMP fragment have been discovered and marketed and have played important roles in crop protection research. It is therefore a timely and valuable task to summarize the rationality on how to create new molecules containing TFMP fragments based on the structure-activity relationships, design mentality, and potential mechanism. This review gives a brief summary on the pesticides containing TFMP fragments in the past 5 years and introduces the latest progress of our group in this field. The aim is to provide readers with a convenient route to touch this topic and hopefully serve some educational purpose for graduate students as well.
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