Journal
JOURNAL OF AFFECTIVE DISORDERS
Volume 305, Issue -, Pages 233-239Publisher
ELSEVIER
DOI: 10.1016/j.jad.2022.02.070
Keywords
Bipolar disorder; Psychotic symptoms; Correlates
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The presence of psychotic symptoms in patients with bipolar disorder is associated with a more severe course of the illness, including lower age of onset, higher episode rates, and higher rates of suicide attempts and hospitalizations. However, the presence of psychotic symptoms is also associated with better cognitive functioning.
Aim: Most of the available data on the prevalence and impact of psychotic symptoms on the course of bipolar disorder (BD) is from Western countries. We aimed to study the prevalence of at least one psychotic episode in the lifetime in patients with BD and its association with the long-term course and outcome. Methodology: 773 patients recruited as part of the Bipolar Disorder Course and Outcome study from India (BiDCoIN study) were divided into 2 groups, based on the presence or absence of at least one psychotic episode in the lifetime. Results: 326 (42.2%) patients had at least one psychotic episode in their lifetime. At least one psychotic episode in the lifetime was associated with overall more severe illness in terms of lower age of onset, a higher number of episodes in the first 5 years of illness; higher rates of BD-II, a higher rate of lifetime history of at least 1 suicide attempt, lifetime history of hospitalization, history of receiving Electroconvulsive Therapy, and a higher prescription rates of antipsychotics. However, presence of psychotics symptoms was associated with better cognitive functioning. Conclusions: Our findings suggest that the presence of psychotic symptoms during episodes in patients with BD is associated with poorer course of BD.
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