Journal
IUBMB LIFE
Volume 74, Issue 8, Pages 794-811Publisher
WILEY
DOI: 10.1002/iub.2603
Keywords
ALS; FTLD; neurodegenerative diseases; oligomers; TDP-43
Categories
Funding
- Ministry of Sciences and Technology, Taiwan [MOST 108-2113-M-001-027]
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This review emphasizes the role of oligomeric TDP-43 in both physiological and pathological conditions and discusses the potential mechanisms of oligomer formation. By studying TDP-43 oligomers, we can gain a better understanding of their involvement in neurodegenerative diseases and provide new therapeutic strategies for these diseases.
TAR DNA-binding protein 43 (TDP-43) is an RNA/DNA-binding protein involved in RNA regulation and diseases. In 2006, TDP-43 inclusions were found in the disease lesions of several neurodegenerative diseases. It is the pathological hallmark in both amyotrophic lateral sclerosis and frontotemporal lobar dementia. It also presents in a large portion of patients with Alzheimer's disease. TDP-43 is prone to aggregate; however, the role of TDP-43 oligomers remains poorly understood in both physiological and pathological conditions. In this review, we emphasize the role of oligomeric TDP-43 in both physiological and pathological conditions and discuss the potential mechanisms of oligomer formation. Finally, we suggest therapeutic strategies against the TDP-43 oligomers in neurodegenerative diseases.
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