Journal
IUBMB LIFE
Volume 74, Issue 8, Pages 763-779Publisher
WILEY
DOI: 10.1002/iub.2613
Keywords
Alzheimer's disease; clinical trials; complementary therapies; Ginkgolides; Huperzine A
Categories
Funding
- Comision Nacional de Investigacion Cientifica y Tecnologica
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2018/07366-4, 2018/08426-0, 2021/00060-0]
- Pro-Reitoria de Pesquisa, Universidade de Sao Paulo [21.1.10424.1.9]
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Alzheimer's disease is a neurodegenerative disorder characterized by cognitive deterioration and currently has no successful pharmacological treatment. However, clinical trials have shown that the commercial formulation EGb 761(R) and Huperzine A have positive effects on improving cognition and daily activities in AD patients.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by gradual deterioration of cognitive function, memory, and inability to perform daily, social, or occupational activities. Its etiology is associated with the accumulation of beta-amyloid peptides, phosphorylated tau protein, and neuroinflammatory and oxidative processes in the brain. Currently, there is no successful pharmacological treatment for AD. The few approved drugs are mainly aimed at treating the symptoms; however, due to the increasing discovery of etiopathological factors, there are great efforts to find new multifunctional molecules to slow down the course of this neurodegenerative disease. The commercial Ginkgo biloba formulation EGb 761 (R) and Huperzine A, an alkaloid present in the plant Huperzia serrata, have shown in clinical trials to possess cholinergic and neuroprotective activities, including improvement in cognition, activities of daily living, and neuropsychiatric symptoms in AD patients. The purpose of this review is to expose the positive results of intervention with EGb 761 (R) and Huperzine in patients with mild to moderate AD in the last 10 years, highlighting the pharmacological functions that justify their use in AD therapy.
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