Waning immunity to inactive SARS-CoV-2 vaccine in healthcare workers: booster required

Article Immunology

Inactive SARS-CoV-2 vaccine generates high antibody responses in healthcare workers with and without prior infection

Harika Oyku Dinc et al.

Summary: Healthcare workers were among the first groups to be vaccinated in Turkey, and two doses of CoronaVac vaccine produced effective humoral immunity in HCWs. The antibody response was significantly higher in those with a prior history of COVID-19, suggesting that a single shot of vaccination may be sufficient for this group.

VACCINE (2022)

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Article Infectious Diseases

Dynamic of humoral response to SARS-CoV-2 anti-Nucleocapsid and Spike proteins after CoronaVac vaccination

Lucas Bochnia-Bueno et al.

Summary: This study aimed to evaluate the immunogenicity of the CoronaVac vaccine in healthcare workers. The results showed a high seroconversion rate of the vaccine in this population.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2022)

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Article Allergy

Short-term immune response after inactivated SARS-CoV-2 (CoronaVac?, Sinovac) and ChAdOx1 nCoV-19 (Vaxzevria?, Oxford-AstraZeneca) vaccinations in health care workers

Watsamon Jantarabenjakul et al.

Summary: This study found that the short-term immune response varied in healthcare workers after receiving inactivated SARS-CoV-2 and ChAdOx1 nCoV-19 vaccines. The immune response declined rapidly after the inactivated vaccine, indicating the need for booster doses.

ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

Wilfredo F. Garcia-Beltran et al.

Summary: New variants of SARS-CoV-2 show high resistance to vaccine neutralization, with some able to escape vaccine responses with just a few mutations, highlighting the importance of developing broadly protective measures against variants.

CELL (2021)

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Article Medicine, General & Internal

Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey

Mine Durusu Tanriover et al.

Summary: The study presented the interim efficacy and safety results of the CoronaVac vaccine in a phase 3 clinical trial in Turkey, demonstrating high efficacy against PCR-confirmed symptomatic COVID-19 with good safety and tolerability profile. Results showed significant differences in the frequency of any adverse events between the vaccine and placebo groups, indicating excellent protective effects of the vaccine.

LANCET (2021)

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Article Medicine, General & Internal

Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile

Alejandro Jara et al.

Summary: A study in Chile involving 10.2 million participants assessed the effectiveness of an inactivated SARS-CoV-2 vaccine developed in China. Fully immunized individuals had vaccine effectiveness of 65.9% for preventing Covid-19 and 87.5% for preventing hospitalization, 90.3% for preventing ICU admission, and 86.3% for preventing death.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Cell Biology

Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals

Alison Tarke et al.

Summary: The study showed that SARS-CoV-2 variants do not significantly disrupt total T cell reactivity, although decreases in response frequency of 10%-22% were observed under certain assay/VOC combinations. This underscores the importance of actively monitoring T cell responses in the context of SARS-CoV-2 evolution.

CELL REPORTS MEDICINE (2021)

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Article Medicine, General & Internal

Humoral Immune Response to SARS-CoV-2 in Iceland

Daniel F. Gudbjartsson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Infectious Diseases

Humoral response and PCR positivity in patients with COVID-19 in the New York City region, USA: an observational study

Ania Wajnberg et al.

LANCET MICROBE (2020)

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Waning immunity to inactive SARS-CoV-2 vaccine in healthcare workers: booster required

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