4.0 Review

Toxicological Implications of Biological Heterogeneity

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

DNA copy number variation: Main characteristics, evolutionary significance, and pathological aspects

Ondrej Pos et al.

Summary: Copy number variants are common features of the human genome, playing roles in evolution, population diversity, disease development, and host-microbiome interactions. They have potential applications in molecular diagnosis and prenatal care, with expected significant impact on screening, diagnosis, prognosis, and monitoring of disorders such as cancer and cardiovascular disease.

BIOMEDICAL JOURNAL (2021)

Article Oncology

A case-control study of a combination of single nucleotide polymorphisms and clinical parameters to predict clinically relevant toxicity associated with fluoropyrimidine and platinum-based chemotherapy in gastric cancer

Miguel Cordova-Delgado et al.

Summary: The study found a high correlation between DPYD SNPs and fluoropyrimidine toxicity in the Latin American population, with significant associations between paired SNPs and toxicity. The multivariate logistic regression model combining multiple factors can accurately predict toxicity, improving treatment prediction accuracy.

BMC CANCER (2021)

Article Toxicology

Cross-species analysis of hepatic cytochrome P450 and transport protein expression

Helen Hammer et al.

Summary: Most drugs and xenobiotics are metabolized in the liver, where cytochrome P450 enzymes and transport proteins play a key role in the process. Variations in the levels of drug-metabolizing enzymes and transporters among different experimental systems determine the pharmacokinetic properties of a compound. By comparing the levels of key proteins in different experimental models, this study provides a comprehensive overview of the similarities and differences in drug metabolism-related proteins.

ARCHIVES OF TOXICOLOGY (2021)

Review Pharmacology & Pharmacy

Role of OATP1B1 and OATP1B3 in Drug-Drug Interactions Mediated by Tyrosine Kinase Inhibitors

Dominique A. Garrison et al.

PHARMACEUTICS (2020)

Article Biochemistry & Molecular Biology

Apolipoprotein E4 exhibits intermediates with domain interaction

Subhrajyoti Dolai et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2020)

Article Medicine, Research & Experimental

Identification and Evaluation of Clinical Substrates of Organic Anion Transporting Polypeptides 1B1 and 1B3

Savannah J. McFeely et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2019)

Review Oncology

Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting

Jiansong Huang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Review Urology & Nephrology

Glycosylation in health and disease

Colin Reily et al.

NATURE REVIEWS NEPHROLOGY (2019)

Article Biochemistry & Molecular Biology

Signatures of Relaxed Selection in the CYP8B1 Gene of Birds and Mammals

Sagar Sharad Shinde et al.

JOURNAL OF MOLECULAR EVOLUTION (2019)

Review Medicine, General & Internal

Genetic Variation, Comparative Genomics, and the Diagnosis of Disease

Evan E. Eichler

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Cell Biology

The N-Glycosylation Processing Potential of the Mammalian Golgi Apparatus

Peter Fisher et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the Brown Planthopper

Christoph T. Zimmer et al.

CURRENT BIOLOGY (2018)

Review Biotechnology & Applied Microbiology

Splicing mutations in human genetic disorders: examples, detection, and confirmation

Anna Abramowicz et al.

JOURNAL OF APPLIED GENETICS (2018)

Article Multidisciplinary Sciences

N-glycan microheterogeneity regulates interactions of plasma proteins

Di Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Pediatrics

Diversity of Human Milk Oligosaccharides and Effects on Early Life Immune Development

Veronica Ayechu-Muruzabal et al.

FRONTIERS IN PEDIATRICS (2018)

Article Evolutionary Biology

Loss of Enzymes in the Bile Acid Synthesis Pathway Explains Differences in Bile Composition among Mammals

Virag Sharma et al.

GENOME BIOLOGY AND EVOLUTION (2018)

Article Biochemistry & Molecular Biology

Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2

Brandon L. Logeman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Gastroenterology & Hepatology

Bile Acid Uptake Transporters as Targets for Therapy

Davor Slijepcevic et al.

DIGESTIVE DISEASES (2017)

Article Biochemistry & Molecular Biology

N-glycoprotein macroheterogeneity: biological implications and proteomic characterization

Lucia F. Zacchi et al.

GLYCOCONJUGATE JOURNAL (2016)

Article Multidisciplinary Sciences

Structural and thermodynamic basis of proline-induced transmembrane complex stabilization

Thomas Schmidt et al.

SCIENTIFIC REPORTS (2016)

Article Genetics & Heredity

Defining mutation and polymorphism in the era of personal genomics

Roshan Karki et al.

BMC MEDICAL GENOMICS (2015)

Article Multidisciplinary Sciences

A global reference for human genetic variation

David M. Altshuler et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Positive Selection during the Evolution of the Blood Coagulation Factors in the Context of Their Disease-Causing Mutations

Pavithra M. Rallapalli et al.

MOLECULAR BIOLOGY AND EVOLUTION (2014)

Article Biochemistry & Molecular Biology

Silent Substitutions Predictably Alter Translation Elongation Rates and Protein Folding Efficiencies

Paige S. Spencer et al.

JOURNAL OF MOLECULAR BIOLOGY (2012)

Review Biochemistry & Molecular Biology

Evolution of ABC transporters by gene duplication and their role in human disease

Karobi Moitra et al.

BIOLOGICAL CHEMISTRY (2011)

Review Genetics & Heredity

Mechanisms of genetically-based resistance to malaria

Carolina Lopez et al.

Article Biology

The rules of variation: Amino acid exchange according to the rotating circular genetic code

Fernando Castro-Chavez

JOURNAL OF THEORETICAL BIOLOGY (2010)

Article Multidisciplinary Sciences

Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict

Cheng Deng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Medical Laboratory Technology

CYP2D6 Genotyping for Functional-Gene Dosage Analysis by Allele Copy Number Detection

Naoya Hosono et al.

CLINICAL CHEMISTRY (2009)

Review Evolutionary Biology

Distinguishing Among Evolutionary Models for the Maintenance of Gene Duplicates

Matthew W. Hahn

JOURNAL OF HEREDITY (2009)

Article Genetics & Heredity

Diet and the evolution of human amylase gene copy number variation

George H. Perry et al.

NATURE GENETICS (2007)

Article Biophysics

Spectrum of disease-causing mutations in protein secondary structures

Sofia Khan et al.

BMC STRUCTURAL BIOLOGY (2007)

Article Multidisciplinary Sciences

A silent polymorphism in the MDR1 gene changes substrate specificity

Chava Kimchi-Sarfaty et al.

SCIENCE (2007)

Review Anesthesiology

Principles of pharmacogenetics - implications for the anaesthetist

G Iohom et al.

BRITISH JOURNAL OF ANAESTHESIA (2004)

Review Pharmacology & Pharmacy

Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry

UM Zanger et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2004)

Review Biotechnology & Applied Microbiology

Pharmacogenetics of oral anticoagulants

AK Daly et al.

PHARMACOGENETICS (2003)

Article Biodiversity Conservation

Save those molecules! Molecular biodiversity and life

AK Campbell

JOURNAL OF APPLIED ECOLOGY (2003)

Article Biotechnology & Applied Microbiology

The amino-acid mutational spectrum of human genetic disease

D Vitkup et al.

GENOME BIOLOGY (2003)

Review Pharmacology & Pharmacy

Molecular genetics of CYP2D6:: Clinical relevance with focus on psychotropic drugs

L Bertilsson et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2002)