Journal
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Volume 114, Issue 4, Pages 666-675Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ijrobp.2022.05.008
Keywords
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Funding
- ViewRay
- Varian Medical Systems
- NH TherAguix
- AstraZeneca
- Genentech
- BMS
- Lilly
- Merck
- Regeneron
- Debiopharm
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This study retrospectively evaluated the outcomes of radiation therapy in patients with oligoprogression on immune check-point inhibitors (ICI). The results showed promising outcomes among patients irradiated for oligoprogression on ICI, especially those with a favorable local response, high tumor programmed death ligand 1 expression, and those receiving ICI for longer periods before oligoprogression.
Purpose: We retrospectively evaluated outcomes after radiation therapy for patients with oligoprogression on immune check-point inhibitors (ICI).Methods and Materials: We identified patients irradiated to <= 5 progressive lesions while receiving ICI between 2010 and 2020. We excluded patients whose systemic therapy was switched after radiation but before progression. We evaluated predic-tors of local control (LC), progression-free survival (PFS) and overall survival (OS).Results: We screened 1423 patients and identified 120 who were eligible; the most common histologies were lung cancer (n = 59) and melanoma (n = 36). The median number of oligoprogressive lesions was 1. For the median LC of irradiated oligoprogressive lesions, PFS and OS were not reached at 6.41 (4.67-7.66) and 29.80 (22.54-43.3 3) months, respectively. Tumor histology, radiated site, or radiation modality were not associated with LC, PFS, or OS. Local response to radiation (P < .0001) and radiation of newly developed lesions (P = .02) were associated with LC. Predictors of PFS on univariate and multivariate analyses were best response to radiation (P = .006) and high programmed death ligand 1 tumor proportion score (P = .02). On multivariate analyses, OS was associated with cumulative oligoprogressive lesion volumes (P = .02) and duration of ICI before oligoprogres-sion (P = .03).Conclusions: Promising outcomes were observed among patients irradiated for oligoprogression on ICI, especially those with a favorable local response, high tumor programmed death ligand 1 expression, and those receiving ICI for longer periods before oligoprogression. These data can help identify patients well suited for radiation therapy versus those who should switch systemic treatment.(c) 2022 Elsevier Inc. All rights reserved.
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