Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 60, Issue 6, Pages -Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2022.5361
Keywords
T cell; T-cell receptor variable beta; prostate cancer; radiation therapy; clonotype frequencies
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Funding
- European Regional Development Fund of the European Union
- Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation [T1EDK-01404]
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This study explored the effect of radiation therapy on the T-cell receptor variable beta chain repertoire in patients with localized prostate cancer. The results showed significant changes in the frequencies of TCR V beta clonotypes after radiation therapy, indicating potential systemic immune changes induced by local treatment.
Radiation therapy (RT) is an essential component in the therapeutic treatment of patients with localized prostate cancer (LPCa). Besides its local effects, ionizing radiation has been linked to mechanisms leading to systemic immune activation. The present study explored the effect of RT on the T-cell receptor variable beta (TCR V beta) chain repertoire of peripheral blood T cells in patients with LPCa. High-throughput TCR V beta sequencing was performed on 20 blood samples collected from patients with LPCa at baseline and 3 months post-RT. The diversity index was altered, as were TCR V beta clonal evenness and convergence before and post-RT; however, these findings were not significant. Notably, marked changes in the frequencies among the top 10 TCR V beta clonotypes were detected and some patients developed new clonotypes of high abundance. These data provided initial evidence that RT in patients with LPCa may induce systemic immune changes, which could be exploited by future therapies for improved clinical results.
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