4.7 Article

Self-Assembled Nano-Peptide Hydrogels with Human Umbilical Cord Mesenchymal Stem Cell Spheroids Accelerate Diabetic Skin Wound Healing by Inhibiting Inflammation and Promoting Angiogenesis

Related references

Note: Only part of the references are listed.
Review Cell & Tissue Engineering

The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review

Donghui Bian et al.

Summary: Recently, mesenchymal stromal cells (MSCs) and their exosomes have become crucial tools in tissue engineering and regenerative medicine. MSCs have the ability to establish skin cells and suppress inflammation, while their exosomes can support wound healing and skin regeneration by delivering functional cargos from MSCs to target cells. The advantages of exosome therapy include reduced risk of tumor formation and lower immunogenicity.

STEM CELL RESEARCH & THERAPY (2022)

Article Pharmacology & Pharmacy

Mesenchymal stem cell-based nanoparticles and scaffolds in regenerative medicine

Pawan Kumar Raghav et al.

Summary: This article discusses the application of mesenchymal stem cells (MSCs) in nanotherapies and scaffold approaches in biomedicine. Nanocomposites are used to encapsulate MSCs or provide support for their growth, and have potential in wound healing, bone and cartilage engineering, cardiac disorders, and neurological disorders.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

Review Cell & Tissue Engineering

Biomaterial-supported MSC transplantation enhances cell-cell communication for spinal cord injury

Bin Lv et al.

Summary: The spinal cord connects the brain to the peripheral nervous system and peripheral tissues through neurons and various types of glial cells. Neurons in the spinal cord process sensory input and control movement. Neurodegenerative disorders and traumatic injuries affecting the spinal cord result in motor deficits and loss of sensory inputs.

STEM CELL RESEARCH & THERAPY (2021)

Review Engineering, Biomedical

Engineering the MSC Secretome: A Hydrogel Focused Approach

Marissa E. Wechsler et al.

Summary: This study reviews the role of hydrogels in modulating the MSC microenvironment, including influencing MSC secretion through cell-matrix and cell-cell interactions, and improving and directing the MSC secretory profile through biochemical cues. The authors suggest future research should focus on understanding how microenvironmental cues impact the MSC secretome and designing the next generation of biomaterials for improved clinical translation outcomes.

ADVANCED HEALTHCARE MATERIALS (2021)

Review Biotechnology & Applied Microbiology

Nanofiber-based systems intended for diabetes

Hassan Maleki et al.

Summary: Diabetic mellitus is a common metabolic disease caused by a defect in insulin secretion, which can be prevented by using nanofiber-based systems to deliver therapeutic agents and cells.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Review Biotechnology & Applied Microbiology

Function and Mechanism of RGD in Bone and Cartilage Tissue Engineering

Meng Yang et al.

Summary: The RGD peptide family is considered as a specific recognition site for the integrin receptors, which play a key role in cell communication. Further research is needed to understand the potential therapeutic and regenerative effects of RGD peptides in bone and cartilage tissue engineering.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

Review Biochemistry & Molecular Biology

Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms

Sujin Kang et al.

Summary: Interleukin-6 (IL-6) plays a key role in inflammation, and blocking its signaling can help in the treatment of various chronic inflammatory diseases. Tocilizumab, an antibody to the IL-6 receptor, has shown therapeutic potential in conditions like rheumatoid arthritis and juvenile systemic idiopathic arthritis.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

Review Engineering, Biomedical

Skin wounds, the healing process, and hydrogel-based wound dressings: a short review

Tainara de Paula de Lima Lima et al.

Summary: Skin wounds result in damage to the epithelial layer and living tissue, with healing process being dynamic and complex. Polymeric hydrogels are effective candidates for wet curing, preventing dehydration of tissue and providing comfort to patients during dressing changes. This review highlights the importance of healing process, different types of skin wounds, and potential benefits of using hydrogels as wound dressings.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2021)

Article Multidisciplinary Sciences

Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation

Ya Guan et al.

Summary: The study developed a sustained oxygenation system using oxygen-release microspheres and a reactive oxygen species (ROS)-scavenging hydrogel to promote diabetic wound healing. The sustained release of oxygen enhanced cell survival and migration, angiogenic growth factor expression, angiogenesis, and decreased proinflammatory cytokine expression in diabetic wounds, leading to a significant increase in wound closure rate.

SCIENCE ADVANCES (2021)

Article Materials Science, Biomaterials

Dual-enzymatically cross-linked gelatin hydrogel enhances neural differentiation of human umbilical cord mesenchymal stem cells and functional recovery in experimental murine spinal cord injury

Minghao Yao et al.

Summary: The study demonstrated the beneficial effects of using a dual-enzymatically cross-linked gelatin hydrogel combined with MSCs for promoting neural repair post-SCI. In both in vitro experiments and a clinically-relevant mouse model, the combination of hydrogel and MSCs led to decreased inflammation, promoted neurogenesis, and improved motor function recovery. The findings suggest that implantation of the designed hydrogel is a promising therapeutic strategy for treating SCI.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Cell Biology

Sodium alginate/collagen hydrogel loaded with human umbilical cord mesenchymal stem cells promotes wound healing and skin remodeling

Zhenkun Zhang et al.

Summary: The injectable SA/Col hydrogel showed promising effects in promoting stem cell retention and survival, reducing wound size, enhancing granulation formation, collagen deposition, and angiogenesis, and modulating inflammation. Additionally, it inhibited the NLRP3 pathway, suggesting its potential for skin wound treatment.

CELL AND TISSUE RESEARCH (2021)

Review Chemistry, Multidisciplinary

Self-Assembling Peptide EAK16 and RADA16 Nanofiber Scaffold Hydrogel

Febrizio Gelain et al.

CHEMICAL REVIEWS (2020)

Review Biotechnology & Applied Microbiology

Nano-drug delivery systems in wound treatment and skin regeneration

Wei Wang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

Review Cell Biology

Mesenchymal Stem Cells for Regenerative Medicine

Yu Han et al.

CELLS (2019)

Article Endocrinology & Metabolism

Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes-2019

William T. Cefalu et al.

DIABETES CARE (2019)

Article Multidisciplinary Sciences

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

W. K. Eddie Ip et al.

SCIENCE (2017)

Article Medicine, General & Internal

Diagnosis and Management of Diabetes: Synopsis of the 2016 American Diabetes Association Standards of Medical Care in Diabetes

James J. Chamberlain et al.

ANNALS OF INTERNAL MEDICINE (2016)

Review Biochemistry & Molecular Biology

Mesenchymal stem cell subpopulations: phenotype, property and therapeutic potential

Miaohua Mo et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Review Cell & Tissue Engineering

Spheroid Culture of Mesenchymal Stem Cells

Zoe Cesarz et al.

STEM CELLS INTERNATIONAL (2016)

Editorial Material Peripheral Vascular Disease

Treatment of Diabetic Complications: How Can We Learn by Seeking and Blundering?

K. Pafili et al.

ANGIOLOGY (2015)

Review Dentistry, Oral Surgery & Medicine

Stem Cells and Calcium Phosphate Cement Scaffolds for Bone Regeneration

P. Wang et al.

JOURNAL OF DENTAL RESEARCH (2014)

Article Endocrinology & Metabolism

Standards of Medical Care in Diabetes--2012

DIABETES CARE (2011)

Review Cell & Tissue Engineering

Mesenchymal Stromal Cells: Facilitators of Successful Transplantation?

Karen English et al.

CELL STEM CELL (2010)