Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/ijms23073926
Keywords
sperm; asthenozoospermia; gene mutation; ion channel; mouse; human
Funding
- INSERM, CNRS
- French National Research Agency (Grant FLAGEL-OME ANR) [19-CE17-0014]
- University Grenoble-Alpes (Grant IRGA-SPERMOBIL 2021)
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Sperm motility and fertilization potential rely on the flagellum and ion channels located on the surface of the sperm cells. This review focuses on the known genetic alterations in humans and additional ion channels identified in mice that affect sperm ion transporters and channels. The potential therapeutic implications for asthenozoospermia and male contraception are also discussed.
In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle that provides the mechanical force for sperm propulsion and motility. Importantly several functional maturation events that occur during the journey of the sperm cells through the genital tracts are necessary for the activation of flagellar beating and the acquisition of fertilization potential. Ion transporters and channels located at the surface of the sperm cells have been demonstrated to be involved in these processes, in particular, through the activation of downstream signaling pathways and the promotion of novel biochemical and electrophysiological properties in the sperm cells. We performed a systematic literature review to describe the currently known genetic alterations in humans that affect sperm ion transporters and channels and result in asthenozoospermia, a pathophysiological condition defined by reduced or absent sperm motility and observed in nearly 80% of infertile men. We also present the physiological relevance and functional mechanisms of additional ion channels identified in the mouse. Finally, considering the state-of-the art, we discuss future perspectives in terms of therapeutics of asthenozoospermia and male contraception.
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