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JOURNAL OF MEDICINAL CHEMISTRY (2016)
Glutaminolysis as a target for cancer therapy
L. Jin et al.
ONCOGENE (2016)
Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer
Caifeng Xie et al.
ONCOTARGET (2016)
Bcl-2 family proteins as regulators of cancer cell invasion and metastasis: a review focusing on mitochondrial respiration and reactive oxygen species
Hong-Duck Um
ONCOTARGET (2016)
Effects of G6PD activity inhibition on the viability, ROS generation and mechanical properties of cervical cancer cells
Zishui Fang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)
Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target
Marina Bolzoni et al.
BLOOD (2016)
Induction of G1-phase cell cycle arrest and apoptosis pathway in MDA-MB-231 human breast cancer cells by sulfated polysaccharide extracted from Laurencia papillosa
Hossam Murad et al.
CANCER CELL INTERNATIONAL (2016)
Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells
Gang Cheng et al.
CANCER RESEARCH (2016)
Determinants of Anti-Cancer Effect of Mitochondrial Electron Transport Chain Inhibitors: Bioenergetic Profile and Metabolic Flexibility of Cancer Cells
Felix A. Urra et al.
CURRENT PHARMACEUTICAL DESIGN (2016)
Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors
Thelma S. Angeles et al.
EXPERT OPINION ON DRUG DISCOVERY (2016)
Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma
Talya L. Dayton et al.
GENES & DEVELOPMENT (2016)
Apple Polyphenol Phloretin Inhibits Colorectal Cancer Cell Growth via Inhibition of the Type 2 Glucose Transporter and Activation of p53-Mediated Signaling
Sheng-Tsai Lin et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2016)
Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission
Haili Wu et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2016)
The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside
J. Azevedo-Silva et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2016)
Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells
Angelika Broer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation
Ninel Azoitei et al.
MOLECULAR CANCER (2016)
Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer
Stepana Boukalova et al.
MOLECULAR CANCER THERAPEUTICS (2016)
SF2312 is a natural phosphonate inhibitor of enolase
Paul G. Leonard et al.
NATURE CHEMICAL BIOLOGY (2016)
Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline
P-P Liu et al.
ONCOGENE (2016)
Metabolic Pathway Signatures Associated with Urinary Metabolite Biomarkers Differentiate Bladder Cancer Patients from Healthy Controls
Won Tae Kim et al.
YONSEI MEDICAL JOURNAL (2016)
Downregulation of ALDOB is associated with poor prognosis of patients with gastric cancer
Jun He et al.
ONCOTARGETS AND THERAPY (2016)
Structural basis for exploring the allosteric inhibition of human kidney type glutaminase
Sarath Ramachandran et al.
ONCOTARGET (2016)
Acidic pH reduces VEGF-mediated endothelial cell responses by downregulation of VEGFR-2; relevance for anti-angiogenic therapies
Seraina Faes et al.
ONCOTARGET (2016)
Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer
Wei Lu et al.
SCIENTIFIC REPORTS (2016)
Glutamate dehydrogenase (GDH) regulates bioenergetics and redox homeostasis in human glioma
Oncotarget (2016)
Metformin Inhibits TGF-β1-Induced Epithelial-to-Mesenchymal Transition via PKM2 Relative-mTOR/p70s6k Signaling Pathway in Cervical Carcinoma Cells
Keyan Cheng et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
Anticancer activity of koningic acid and semisynthetic derivatives
Nicolas J. Rahier et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias
Maria Rosaria Ricciardi et al.
BLOOD (2015)
Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth
Lingtao Jin et al.
CANCER CELL (2015)
Safety, efficacy, and pharmacokinetics of navitoclax (ABT-263) in combination with erlotinib in patients with advanced solid tumors
Anthony W. Tolcher et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2015)
Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: Involvement of the Akt-mTOR signaling pathway
Zhi Zhao et al.
CANCER LETTERS (2015)
Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death
Eric A. Lee et al.
CANCER RESEARCH (2015)
Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer
Mohamed Hassanein et al.
INTERNATIONAL JOURNAL OF CANCER (2015)
Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
Kazuhiro Tanaka et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells
Xiaoyun Han et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2015)
Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development
Qian Wang et al.
JOURNAL OF PATHOLOGY (2015)
Lack of Evidence for PKM2 Protein Kinase Activity
Aaron M. Hosios et al.
MOLECULAR CELL (2015)
Zoledronic acid inhibits the pentose phosphate pathway through attenuating the Ras-TAp73-G6PD axis in bladder cancer cells
Xiaolin Wang et al.
MOLECULAR MEDICINE REPORTS (2015)
Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1
Lan Lan et al.
MOLECULAR ONCOLOGY (2015)
Inhibitory effects of 3-bromopyruvate in human nasopharyngeal carcinoma cells
Xue Zou et al.
ONCOLOGY REPORTS (2015)
Energy Metabolism in a Matched Model of Radiation Resistance for Head and Neck Squamous Cell Cancer
Jade Mims et al.
RADIATION RESEARCH (2015)
F-18 Fluoromisonidazole for Imaging Tumor Hypoxia: Imaging the Microenvironment for Personalized Cancer Therapy
Joseph G. Rajendran et al.
SEMINARS IN NUCLEAR MEDICINE (2015)
Inhibition of LDHA suppresses tumor progression in prostate cancer
Zhi-Yong Xian et al.
TUMOR BIOLOGY (2015)
Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death
Daniela Catanzaro et al.
ONCOTARGET (2015)
Metabolomic profile of glycolysis and the pentose phosphate pathway identifies the central role of glucose-6-phosphate dehydrogenase in clear cell-renal cell carcinoma
Giuseppe Lucarelli et al.
ONCOTARGET (2015)
Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents
Valeria Di Bussolo et al.
RSC ADVANCES (2015)
Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis
Takla Griss et al.
PLOS BIOLOGY (2015)
Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression
Richard Ventura et al.
EBIOMEDICINE (2015)
Targeting the Metabolic Plasticity of Multiple Myeloma with FDA-Approved Ritonavir and Metformin
Sevim Dalva-Aydemir et al.
CLINICAL CANCER RESEARCH (2015)
SF3B1 mutations constitute a novel therapeutic target in breast cancer
Sarah L. Maguire et al.
JOURNAL OF PATHOLOGY (2015)
ATF4 and N-Myc coordinate glutamine metabolism in MYCN-amplified neuroblastoma cells through ASCT2 activation
Ping Ren et al.
JOURNAL OF PATHOLOGY (2015)
Past, present and future role of chlorambucil in the treatment of chronic lymphocytic leukemia
Valentin Goede et al.
LEUKEMIA & LYMPHOMA (2015)
First-in-human investigation of the oral first-in-class fatty acid synthase (FASN) inhibitor, TVB-2640.
Andrew Jacob Brenner et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
Pharmacokinetics and Pharmacodynamics of Phenethyl Isothiocyanate: Implications in Breast Cancer Prevention
Marilyn E. Morris et al.
AAPS JOURNAL (2014)
Mito-DCA: A Mitochondria Targeted Molecular Scaffold for Efficacious Delivery of Metabolic Modulator Dichloroacetate
Rakesh K. Pathak et al.
ACS CHEMICAL BIOLOGY (2014)
3-Bromopyruvic Acid, A Hexokinase II Inhibitor, is an Effective Antitumor Agent on the Hepatoma Cells: in vitro and in vivo Findings
Lei Gong et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2014)
A proapoptotic peptide conjugated to penetratin selectively inhibits tumor cell growth
Isabel D. Alves et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2014)
Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia
M. Maftouh et al.
BRITISH JOURNAL OF CANCER (2014)
PKM2 as a biomarker for chemosensitivity to front-line platinum-based chemotherapy in patients with metastatic non-small-cell lung cancer
C. Papadaki et al.
BRITISH JOURNAL OF CANCER (2014)
Mitochondria-targeted Resveratrol Derivatives Act as Cytotoxic Pro-oxidants
Nicola Sassi et al.
CURRENT PHARMACEUTICAL DESIGN (2014)
A phase I clinical trial of navitoclax, a targeted high-affinity Bcl-2 family inhibitor, in combination with gemcitabine in patients with solid tumors
James M. Cleary et al.
INVESTIGATIONAL NEW DRUGS (2014)
A phase I safety and pharmacokinetic study of ABT-263 in combination with carboplatin/paclitaxel in the treatment of patients with solid tumors
Gordana Vlahovic et al.
INVESTIGATIONAL NEW DRUGS (2014)
ErbB2 Activation Upregulates Glutaminase 1 Expression Which Promotes Breast Cancer Cell Proliferation
Shuo Qie et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2014)
Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis
Susanne Grube et al.
JOURNAL OF NEURO-ONCOLOGY (2014)
Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer
Matt I. Gross et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer
Isabel R. Schlaepfer et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex
Jun Fan et al.
MOLECULAR CELL (2014)
Mitochondrial Delivery of Doxorubicin via Triphenylphosphine Modification for Overcoming Drug Resistance in MDA-MB-435/DOX Cells
Min Han et al.
MOLECULAR PHARMACEUTICS (2014)
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
Anila K. Madiraju et al.
NATURE (2014)
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Andrea Viale et al.
NATURE (2014)
Role of aldolase A in osteosarcoma progression and metastasis: In vitro and in vivo evidence
Feng Long et al.
ONCOLOGY REPORTS (2014)
Mitochondrial-Targeted Curcuminoids: A Strategy to Enhance Bioavailability and Anticancer Efficacy of Curcumin
Cheruku Apoorva Reddy et al.
PLOS ONE (2014)
Switching of Pyruvate Kinase Isoform L to M2 Promotes Metabolic Reprogramming in Hepatocarcinogenesis
Carmen Chak-Lui Wong et al.
PLOS ONE (2014)
Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest
Yusong Zhang et al.
ONCOLOGY LETTERS (2014)
Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense
Angelo D'Alessandro et al.
ONCOTARGET (2014)
Regulation of the pentose phosphate pathway in cancer
Peng Jiang et al.
PROTEIN & CELL (2014)
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis
William W. Wheaton et al.
ELIFE (2014)
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study
Salah Mohamed El Sayed et al.
CHINESE JOURNAL OF CANCER (2014)
Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane
Tamir Epstein et al.
CANCER & METABOLISM (2014)
Metformin directly acts on mitochondria to alter cellular bioenergetics
Sylvia Andrzejewski et al.
CANCER & METABOLISM (2014)
Efficacy of Novel Glutaminase Inhibitor CB-839 in Acute Myeloid Leukemia
Polina Matre et al.
BLOOD (2014)
Galloflavin suppresses lactate dehydrogenase activity and causes MYC downregulation in Burkitt lymphoma cells through NAD/NADH-dependent inhibition of sirtuin-1
Marina Vettraino et al.
ANTI-CANCER DRUGS (2013)
S-benzyl-cysteine-mediated Cell Cycle Arrest and Apoptosis Involving Activation of Mitochondrial-dependent Caspase Cascade through the p53 Pathway in Human Gastric Cancer SGC-7901 Cells
Hua-Jun Sun et al.
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2013)
Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors
Ajit G. Thomas et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
How does the metabolism of tumour cells differ from that of normal cells
Nivea Dias Amoedo et al.
BIOSCIENCE REPORTS (2013)
Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death
Gang Cheng et al.
BMC CANCER (2013)
PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells
William J. Israelsen et al.
CELL (2013)
Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor
Emilia C. Calvaresi et al.
CHEMBIOCHEM (2013)
SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival
Mohamed Hassanein et al.
CLINICAL CANCER RESEARCH (2013)
Targeting the Mitochondrial Electron Transport Chain Complexes for the Induction of Apoptosis and Cancer Treatment
Jakub Rohlena et al.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2013)
Inhibition of Carnitine Palmitoyltransferase-1 Activity Alleviates Insulin Resistance in Diet-Induced Obese Mice
Wendy Keung et al.
DIABETES (2013)
Small-molecule inhibitors of human LDH5
Carlotta Granchi et al.
FUTURE MEDICINAL CHEMISTRY (2013)
Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells
Risa Shiragami et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2013)
Aberrant Overexpression of Pyruvate Kinase M2 Is Associated With Aggressive Tumor Features and the BRAF Mutation in Papillary Thyroid Cancer
Chen Feng et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)
Mitochondria-Targeted Nitroxide, Mito-CP, Suppresses Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo
Dmytro Starenki et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)
Glutamine and cancer: cell biology, physiology, and clinical opportunities
Christopher T. Hensley et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
A Selective Mitochondrial-Targeted Chlorambucil with Remarkable Cytotoxicity in Breast and Pancreatic Cancers
Melissa Millard et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Carnitine-Acyltransferase System Inhibition, Cancer Cell Death, and Prevention of Myc-Induced Lymphomagenesis
Annalisa Pacilli et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)
Classification of mitocans, anti-cancer drugs acting on mitochondria
Jiri Neuzil et al.
MITOCHONDRION (2013)
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
Jaekyoung Son et al.
NATURE (2013)
Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation
Fang Wang et al.
SCIENCE (2013)
Targeting cellular metabolism to improve cancer therapeutics
Y. Zhao et al.
CELL DEATH & DISEASE (2013)
Glycolysis Back in the Limelight: Systemic Targeting of HK2 Blocks Tumor Growth
Susana Ros et al.
CANCER DISCOVERY (2013)
Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells
Julia Billiard et al.
CANCER & METABOLISM (2013)
Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism
Susana Ros et al.
CANCER & METABOLISM (2013)
Cancer metabolism: fatty acid oxidation in the limelight
Arkaitz Carracedo et al.
NATURE REVIEWS CANCER (2013)
Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy
Subash C. Gupta et al.
ANTIOXIDANTS & REDOX SIGNALING (2012)
Therapeutic and Toxicologic Evaluation of Anti-Lipogenic Agents in Cancer Cells Compared with Non-Neoplastic Cells
Perinkulam Ravi Deepa et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2012)
Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules
Shiva Kant et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2012)
An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression
Natalie E. Simpson et al.
BREAST CANCER RESEARCH AND TREATMENT (2012)
Analysis of glutamine dependency in non-small cell lung cancer GLS1 splice variant GAC is essential for cancer cell growth
A. Pieter et al.
CANCER BIOLOGY & THERAPY (2012)
Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth
Taro Hitosugi et al.
CANCER CELL (2012)
Vitamin K3 and K5 are inhibitors of tumor pyruvate kinase M2
Jing Chen et al.
CANCER LETTERS (2012)
Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
Anne Le et al.
CELL METABOLISM (2012)
Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase
Marcella Manerba et al.
CHEMMEDCHEM (2012)
Mitochondrial VDAC1: Function in Cell Life and Death and a Target for Cancer Therapy
V. Shoshan-Barmatz et al.
CURRENT MEDICINAL CHEMISTRY (2012)
Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways
F. Farabegoli et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2012)
Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy
Zhiyu Wang et al.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012)
Experimental results using 3-bromopyruvate in mesothelioma: in vitro and in vivo studies
Philippe Icard et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2012)
A translational study case report on the small molecule energy blocker 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside
Y. H. Ko et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2012)
Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target
Marco Gerlinger et al.
JOURNAL OF PATHOLOGY (2012)
A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo
Yi Liu et al.
MOLECULAR CANCER THERAPEUTICS (2012)
Passenger deletions generate therapeutic vulnerabilities in cancer
Florian L. Muller et al.
NATURE (2012)
IDH mutation status in prostate cancer
A. F. Ghiam et al.
ONCOGENE (2012)
Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping
Darrell R. Borger et al.
ONCOLOGIST (2012)
Identification and Functional Expression of the Mitochondrial Pyruvate Carrier
Sebastien Herzig et al.
SCIENCE (2012)
Inhibition of Fatty-acid Synthase Suppresses P-AKT and Induces Apoptosis in Bladder Cancer
Bo Jiang et al.
UROLOGY (2012)
N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation
Carlotta Granchi et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Green Tea Polyphenols Control Dysregulated Glutamate Dehydrogenase in Transgenic Mice by Hijacking the ADP Activation Site
Changhong Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress and Mitochondrial Dysfunction Contribute to Polydatin-Induced Apoptosis in Human Nasopharyngeal Carcinoma CNE Cells
Huanhai Liu et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2011)
Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells
Carlotta Granchi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells
Jun Fan et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Is there a role for carbohydrate restriction in the treatment and prevention of cancer?
Rainer J. Klement et al.
NUTRITION & METABOLISM (2011)
Otto Warburg's contributions to current concepts of cancer metabolism
Willem H. Koppenol et al.
NATURE REVIEWS CANCER (2011)
Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer
Avaniyapuram Kannan Murugan et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1
Meghan J. Seltzer et al.
CANCER RESEARCH (2010)
Ketones and lactate fuel tumor growth and metastasis Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
Gloria Bonuccelli et al.
CELL CYCLE (2010)
Inhibitors of Lactate Dehydrogenase Isoforms and their Therapeutic Potentials
C. Granchi et al.
CURRENT MEDICINAL CHEMISTRY (2010)
The Antioxidant Transcription Factor Nrf2 Negatively Regulates Autophagy and Growth Arrest Induced by the Anticancer Redox Agent Mitoquinone
V. Ashutosh Rao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
Johanna Chiche et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2010)
Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
Ismael Samudio et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication
Peter Paschka et al.
JOURNAL OF CLINICAL ONCOLOGY (2010)
Small mitochondria-targeting molecules as anti-cancer agents
Feng Wang et al.
MOLECULAR ASPECTS OF MEDICINE (2010)
Gossypol Induces Apoptosis by Activating p53 in Prostate Cancer Cells and Prostate Tumor-Initiating Cells
Suresh R. Volate et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Targeting mitochondria for cancer therapy
Simone Fulda et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Myocardial Fatty Acid Metabolism in Health and Disease
Gary D. Lopaschuk et al.
PHYSIOLOGICAL REVIEWS (2010)
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
Anne Le et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
Frank Weinberg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery
B. Zhivotovsky et al.
CELL DEATH AND DIFFERENTIATION (2009)
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
Mi Ran Kang et al.
INTERNATIONAL JOURNAL OF CANCER (2009)
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
Ping Gao et al.
NATURE (2009)
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Dunyaporn Trachootham et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
Elaine R. Mardis et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Evaluation of Dichloroacetic Acid for Carcinogenicity in Genetically Modified Tg.AC Hemizygous and p53 Haploinsufficient Mice
Grace E. Kissling et al.
TOXICOLOGICAL SCIENCES (2009)
Bioreductive activation of quinone antitumor drugs by mitochondrial voltage-dependent anion channel 1
Eriko Simamura et al.
ANATOMICAL SCIENCE INTERNATIONAL (2008)
Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism
Dunyaporn Trachootham et al.
BLOOD (2008)
Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation - Implications for the response to hormonal therapy
Isabelle Mercier et al.
CANCER BIOLOGY & THERAPY (2008)
DNA polymerase γ inhibition by vitamin K3 induces mitochondria-mediated cytotoxicity in human cancer cells
Ryohei Sasaki et al.
CANCER SCIENCE (2008)
Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model
Marco A. Carvalho et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
Characterization of L-aminocarnitine, an inhibitor of fatty acid oxidation
Malika Chegary et al.
MOLECULAR GENETICS AND METABOLISM (2008)
Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)
Mary M. Robinson et al.
BIOCHEMICAL JOURNAL (2007)
A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: the ERGO (etomoxir for the recovery of glucose oxidation) study
Christian J. F. Holubarsch et al.
CLINICAL SCIENCE (2007)
Perhexiline
Houman Ashrafian et al.
CARDIOVASCULAR DRUG REVIEWS (2007)
Mitocans: Mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents
Stephen J. Ralph et al.
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2006)
Inhibition of endothelial cell proliferation and angiogenesis by orlistat, a fatty acid synthase inhibitor
Cecille D. Browne et al.
FASEB JOURNAL (2006)
Growth arrest induced by C75, a fatty acid synthase inhibitor, was partially modulated by p38 MAPK but not by p53 in human hepatocellular carcinoma
Yan Gao et al.
CANCER BIOLOGY & THERAPY (2006)
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R Varshney et al.
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JW Kim et al.
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J Verrax et al.
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AS Don et al.
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M Kunkel et al.
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B Notario et al.
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