Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/ijms23105602
Keywords
lung cancer; NMR (nuclear magnetic resonance); metabolism
Funding
- Hasselt University via the Hercules project [AUHL/15/2-GOH3816N]
- Research Foundation Flanders (FWO Vlaanderen) via the Hercules project [AUHL/15/2-GOH3816N]
- Kom Op Tegen Kanker [R-8585]
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In this paper, the authors discuss the metabolic changes in lung cancer patients and the metabolic cooperation between tumor cells and healthy tissue, as well as the potential application of metabolomics in the management of lung cancer patients.
Lung cancer cells are well documented to rewire their metabolism and energy production networks to enable proliferation and survival in a nutrient-poor and hypoxic environment. Although metabolite profiling of blood plasma and tissue is still emerging in omics approaches, several techniques have shown potential in cancer diagnosis. In this paper, the authors describe the alterations in the metabolic phenotype of lung cancer patients. In addition, we focus on the metabolic cooperation between tumor cells and healthy tissue. Furthermore, the authors discuss how metabolomics could improve the management of lung cancer patients.
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