4.7 Article

Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Gamma-tocotrienol, a radiation countermeasure, reverses proteomic changes in serum following total-body gamma irradiation in mice

Elliot Rosen et al.

Summary: The study found that prophylactic administration of gamma-tocotrienol (GT3) provided 100% protection in a mouse model of total-body irradiation. Protein analysis identified specific serum proteins associated with radiation injury and protection.

SCIENTIFIC REPORTS (2022)

Review Cell Biology

Cell fate specification and differentiation in the adult mammalian intestine

Joep Beumer et al.

Summary: Intestinal stem cells fuel tissue renewal, with the epithelium absorbing nutrients while acting as a barrier, lineage plasticity and niche signals enable efficient tissue repair, new insights from single-cell transcriptomics and organoid models reveal the importance of cell lineage plasticity and niche signals for tissue repair.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

TUNEL Assay: A Powerful Tool for Kidney Injury Evaluation

Christopher L. Moore et al.

Summary: TUNEL is a well-established assay for detecting cell death-associated DNA fragmentation that is particularly active in the kidney and widely used for identifying and quantifying DNA fragmentation and cell death in kidney cells and tissues. Despite initial misinterpretation as an apoptotic assay, TUNEL is gaining popularity in kidney injury assessment due to its universal applicability and ability to provide additional information on cell death mechanisms.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Gastroenterology & Hepatology

The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair

Wei-Ting Kuo et al.

Summary: The study found that ZO-1 expression was reduced in biopsy specimens from patients with inflammatory bowel disease. Despite mildly increased intestinal permeability, ZO-1(KO.IEC) mice were healthy and did not develop spontaneous disease. However, these mice were hypersensitive to mucosal insults and displayed defective repair.

GASTROENTEROLOGY (2021)

Review Biology

Radiation countermeasures for hematopoietic acute radiation syndrome: growth factors, cytokines and beyond

Vijay K. Singh et al.

Summary: This article reports on the status of pharmaceuticals in late stage development for treating acute injuries caused by radiological/nuclear exposures. Four medications have been deemed safe and effective by the US FDA for hematopoietic acute radiation syndrome (H-ARS), primarily recombinant growth factors. Additional medications are needed for other sub-syndromes of ARS, potentially through a polypharmaceutical or bioengineered approach.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Biology

Differential Recovery of Small Intestinal Segments after Partial-Body Irradiation in Non-Human Primates

Junru Wang et al.

Summary: This study investigated the recovery rate and extent of recovery from partial-body irradiation-induced intestinal damage in large animals. The results showed that higher radiation doses led to more severe damage at 10 days post-PBI, but with a faster recovery rate. However, at 60 days post-PBI, damage was still evident in all regions of the intestine, with the duodenum and ileum sustaining less damage and recovering more fully than the jejunum.

RADIATION RESEARCH (2021)

Article Biochemistry & Molecular Biology

A Metabolomic and Lipidomic Serum Signature from Nonhuman Primates Administered with a Promising Radiation Countermeasure, Gamma-Tocotrienol

Amrita K. Cheema et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Pharmacology & Pharmacy

Tocotrienols: The promising analogues of vitamin E for cancer therapeutics

Bethsebie Lalduhsaki Sailo et al.

PHARMACOLOGICAL RESEARCH (2018)

Editorial Material Pharmacology & Pharmacy

Opportunities and challenges with animal models for acute radiation syndrome drug discovery

Vijay K. Singh et al.

EXPERT OPINION ON DRUG DISCOVERY (2018)

Review Pharmacology & Pharmacy

Nonhuman primates as models for the discovery and development of radiation countermeasures

Vijay K. Singh et al.

EXPERT OPINION ON DRUG DISCOVERY (2017)

Article Cell Biology

Evolutionarily conserved serum microRNAs predict radiation-induced fatality in nonhuman primates

Wojciech Fendler et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Gastroenterology & Hepatology

Rapid disruption of intestinal epithelial tight junction and barrier dysfunction by ionizing radiation in mouse colon in vivo: protection by N-acetyl-L-cysteine

Pradeep K. Shukla et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2016)

Article Biochemistry & Molecular Biology

β-Arrestin-2 modulates radiation-induced intestinal crypt progenitor/stem cell injury

Z. Liu et al.

CELL DEATH AND DIFFERENTIATION (2016)

Article Biology

Radioprotective Efficacy of Gamma-Tocotrienol in Nonhuman Primates

Vijay K. Singh et al.

RADIATION RESEARCH (2016)

Review Biochemistry & Molecular Biology

γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status

Vijay K. Singh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Review Pharmacology & Pharmacy

Animal models for acute radiation syndrome drug discovery

Vijay K. Singh et al.

EXPERT OPINION ON DRUG DISCOVERY (2015)

Article Chemistry, Medicinal

Building the Strategic National Stockpile Through the NIAID Radiation Nuclear Countermeasures Program

Carmen I. Rios et al.

DRUG DEVELOPMENT RESEARCH (2014)

Article Multidisciplinary Sciences

Progenitors Mobilized by Gamma-Tocotrienol as an Effective Radiation Countermeasure

Vijay K. Singh et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome

Naoki Takemura et al.

NATURE COMMUNICATIONS (2014)

Review Biochemistry & Molecular Biology

Regulation of intestinal epithelial permeability by tight junctions

Takuya Suzuki

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

Review Biology

Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures

Vijay K. Singh et al.

JOURNAL OF RADIATION RESEARCH (2013)

Article Physiology

Protective effect of zinc-N-acetylcysteine on the rat kidney during cold storage

Mandeep Singh et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)

Article Immunology

Gamma-tocotrienol, a radiation prophylaxis agent, induces high levels of granulocyte colony-stimulating factor

Shilpa S. Kulkarni et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2012)

Review Medicine, General & Internal

Acute radiation syndrome caused by accidental radiation exposure - therapeutic principles

Harald Doerr et al.

BMC MEDICINE (2011)

Article Biology

Animal Models for Medical Countermeasures to Radiation Exposure

Jacqueline P. Williams et al.

RADIATION RESEARCH (2010)

Article Biology

Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector

Sanchita P. Ghosh et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2009)

Review Immunology

Intestinal mucosal barrier function in health and disease

Jerrold R. Turner

NATURE REVIEWS IMMUNOLOGY (2009)

Review Oncology

Multitargeted therapy of cancer by tocotrienols

Kalanithi Nesaretnam

CANCER LETTERS (2008)

Article Gastroenterology & Hepatology

Acute and persisting Th2-like immune response after fractionated colorectal γ-irradiation

Olivier Gremy et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2008)

Letter Biochemistry & Molecular Biology

Role of EndoG in development and cell injury

E. O. Apostolov et al.

CELL DEATH AND DIFFERENTIATION (2007)

Article Biochemistry & Molecular Biology

Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase stimulated by δ- and γ-tocotrienols

Bao-Liang Song et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Medicine, General & Internal

ABC of conflict and disaster - Weapons of mass destruction - threats and responses

C Gosden et al.

BRITISH MEDICAL JOURNAL (2005)

Article Gastroenterology & Hepatology

Structural and functional alterations of the gastrointestinal tract following radiation-induced injury in the rhesus monkey

RM Vigneulle et al.

DIGESTIVE DISEASES AND SCIENCES (2002)

Article Chemistry, Inorganic & Nuclear

Accuracy considerations in EPR dosimetry

V Nagy

APPLIED RADIATION AND ISOTOPES (2000)