Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 64, Issue 45, Pages 8633-8639Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.6b03368
Keywords
antibacterial photosensitization-based treatment; natural photosensitizers; singlet oxygen
Funding
- Spanish Ministry of Economy and Competitiveness [CTQ2013-48767-C3-1-R]
- University of Parma
- Nikon Imaging Center at the Fondazione Istituto Italiano di Tecnologia
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Zinc-substituted myoglobin (ZnMb) is a naturally occurring photosensitizer that generates singlet oxygen with a high quantum yield. Using a combination of photophysical and fluorescence imaging techniques, we demonstrate the interaction of ZnMb with Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. An efficient antibacterial action against S. aureus was observed, with a reduction up to 99.9999% in the number of colony-forming units, whereas no sizable effect was detected against E. coli. Because ZnMb is known to form during the maturation of additive-free not-cooked cured ham, the use of this protein as a built-in photodynamic agent may constitute a viable method for the decontamination of these food products from Gram-positive bacteria.
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