Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ijms23084342
Keywords
carbonic anhydrase; carbonic anhydrase related proteins; acid-base balance; ion transport; pH regulation; motor coordination; zebrafish
Funding
- Finnish Cultural Foundation
- Jane and Aatos Erkko Foundation
- Tampere Tuberculosis Foundation
- Academy of Finland
- Sigrid Juselius Foundation
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Zebrafish have become a crucial model organism for studying various physiological and biological phenomena. Carbonic anhydrases (CAs) and carbonic anhydrase related proteins (CARPs) play important roles in multiple physiological processes, including pigmentation and motor coordination in zebrafish. Disruption of these proteins' function in zebrafish can have lethal outcomes.
During recent decades, zebrafish (Danio rerio) have become one of the most important model organisms in which to study different physiological and biological phenomena. The research field of carbonic anhydrases (CAs) and carbonic anhydrase related proteins (CARPs) is not an exception to this. The best-known function of CAs is the regulation of acid-base balance. However, studies performed with zebrafish, among others, have revealed important roles for these proteins in many other physiological processes, some of which had not yet been predicted in the light of previous studies and suggestions. Examples include roles in zebrafish pigmentation as well as motor coordination. Disruption of the function of these proteins may generate lethal outcomes. In this review, we summarize the current knowledge of CA-related studies performed in zebrafish from 1993-2021 that was obtained from PubMed search.
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