Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/ijms23063135
Keywords
B; coagulans; CAZymes; bacteriocins; CRISPR-Cas systems
Funding
- PRIN 2017-PANACEA [CUP E69E19000530001]
- GoodbyWaste: ObtainGOOD products-exploit BY-products-reduce WASTE, Italy [MIUR 2017-JTNK78.006]
- Novo Nordisk Foundation/Hallas-Moeller Ascending Investigator Grant [NNF17OC0031154]
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This study presents a comparative genomic analysis of nine strains of Weizmannia coagulans, focusing on their repertoire of Carbohydrate-Active enZymes (CAZymes), secretion systems, and resistance mechanisms. The study also analyzes the CRISPR immune system and CRISPR-associated (Cas) genes. Overall, this research provides valuable insights into the genomic diversity of W. coagulans and its potential applications in biotechnology.
The production of biochemicals requires the use of microbial strains with efficient substrate conversion and excellent environmental robustness, such as Weizmannia coagulans species. So far, the genomes of 47 strains have been sequenced. Herein, we report a comparative genomic analysis of nine strains on the full repertoire of Carbohydrate-Active enZymes (CAZymes), secretion systems, and resistance mechanisms to environmental challenges. Moreover, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) immune system along with CRISPR-associated (Cas) genes, was also analyzed. Overall, this study expands our understanding of the strain's genomic diversity of W. coagulans to fully exploit its potential in biotechnological applications.
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