A Comparative Analysis of Weizmannia coagulans Genomes Unravels the Genetic Potential for Biotechnological Applications

The production of biochemicals requires the use of microbial strains with efficient substrate conversion and excellent environmental robustness, such as Weizmannia coagulans species. So far, the genomes of 47 strains have been sequenced. Herein, we report a comparative genomic analysis of nine strains on the full repertoire of Carbohydrate-Active enZymes (CAZymes), secretion systems, and resistance mechanisms to environmental challenges. Moreover, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) immune system along with CRISPR-associated (Cas) genes, was also analyzed. Overall, this study expands our understanding of the strain's genomic diversity of W. coagulans to fully exploit its potential in biotechnological applications.

Automated summary

This study presents a comparative genomic analysis of nine strains of Weizmannia coagulans, focusing on their repertoire of Carbohydrate-Active enZymes (CAZymes), secretion systems, and resistance mechanisms. The study also analyzes the CRISPR immune system and CRISPR-associated (Cas) genes. Overall, this research provides valuable insights into the genomic diversity of W. coagulans and its potential applications in biotechnology.