Related references
Note: Only part of the references are listed.
Review
Biochemistry & Molecular Biology
Larisa V. Volkova et al.
Summary: Cervical cancer is a common and lethal type of carcinoma affecting women worldwide. Current research is focused on understanding the oncology, oncobiology, and oncomorphology of cervical cancer, exploring various methods of investigation, and searching for targeted treatments and biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Olga Troitskaya et al.
Summary: The study showed that MCF7 cells with high EGFR expression can quickly form spheroids enriched with cancer stem cells, which are characterized by lower drug resistance compared to normal MCF7 cells. These MCF7-EGFR spheroids serve as a useful cancer model for drug development, especially EGFR-targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Patrycja Gralewska et al.
Summary: This study demonstrated that the combination treatment of olaparib and metformin had a significant inhibitory effect on HR-proficient ovarian cancer cells, inducing apoptosis by increasing ROS levels. The synergistic effect was observed in cells with mutant or null p53, providing a new approach for the treatment of gynecologic cancers. The results support the use of metformin to enhance the sensitivity of EOC to olaparib therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tsui-Lien Mao et al.
Summary: The upregulation of MALAT1 in epithelial ovarian cancer is associated with activation of tumor-related signaling pathways, influencing apoptosis, inflammation, proliferation, and invasion processes in cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kelly Pedrozo Ferreira et al.
Summary: This study found that CD63 is highly expressed in vulvar squamous cell carcinoma (VSCC), and that CD9 is associated with tumor size, CD63 upregulation is associated with histological diagnosis and vascular invasion, while low expression of CD81 and CD82 is linked to worse prognosis. Furthermore, CD63 and CD82 may be potential therapeutic targets in VSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Woo Yeon Hwang et al.
Summary: DFMO significantly reduces cell viability in ovarian cancer cells through polyamine depletion and apoptosis pathways, as well as by mediating through AP-1, activating JNK, and enhancing the effect of cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tomohito Tanaka et al.
Summary: A systematic review of publications on PDX models of cervical cancer reveals that severe immunodeficient mice and subrenal capsule implantation lead to higher engraftment rates; fragments sized 1-3 mm(3) are suitable for CC-PDX; no clear association was found between tumor and donor patient characteristics and engraftment rates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tomohiko Fukuda et al.
Summary: The study found that BMP signaling promotes EC tumorigenesis, while TWSG1 antagonizes BMP7 in EC. BMP signaling inhibitors, in combination with chemotherapy, might be useful in the treatment of EC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Nuria Carreras-Dieguez et al.
Summary: VSCC is a rare malignancy with dual pathogenesis, HPV-associated and HPV-independent, and the molecular landscape of this neoplasm remains poorly explored. Studies have shown highly variable gene mutations across different series, and the role of these mutations in VSCC development is still unclear. Large-scale genomic studies with robust HPV testing are needed to improve the molecular characterization of VSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)