Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/ijms23052863
Keywords
high throughput; drug screening; AI; leukemia; personalized medicine
Funding
- NMRC Centre Grant Programme--Targeted Therapy for Blood Cancer [NMRC/CG/C012A/2017]
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Acute myeloid leukemia (AML) is a complex hematological malignancy with extensive heterogeneity, making it a prototype for personalized medicine. Recent studies have shown the potential of implementing genomic and phenotypic screens to improve survival in refractory AML patients.
Acute myeloid leukemia (AML) is a complex hematological malignancy characterized by extensive heterogeneity in genetics, response to therapy and long-term outcomes, making it a prototype example of development for personalized medicine. Given the accessibility to hematologic malignancy patient samples and recent advances in high-throughput technologies, large amounts of biological data that are clinically relevant for diagnosis, risk stratification and targeted drug development have been generated. Recent studies highlight the potential of implementing genomic-based and phenotypic-based screens in clinics to improve survival in patients with refractory AML. In this review, we will discuss successful applications as well as challenges of most up-to-date high-throughput technologies, including artificial intelligence (AI) approaches, in the development of personalized medicine for AML, and recent clinical studies for evaluating the utility of integrating genomics-guided and drug sensitivity testing-guided treatment approaches for AML patients.
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