4.7 Article

Near-Complete Remission of Glioblastoma in a Patient Treated with an Allogenic Dendritic Cell-Based Vaccine: The Role of Tumor-Specific CD4+T-Cell Cytokine Secretion Pattern in Predicting Response and Recurrence

Journal

Publisher

MDPI
DOI: 10.3390/ijms23105396

Keywords

glioblastoma; immunotherapy; dendritic cells; CD4+T cells; vaccine; cancer treatment

Funding

  1. Fundacao Faculdade de Medicina, Universidade de Sao Paulo, Brazil
  2. Sao Paulo Research Foundation-FAPESP [2014/25988-1, 2016/01137-8]
  3. Coordination for the Improvement of Higher Education Personnel-CAPES
  4. National Council for Scientific and Technological Development-CNPq [409825/2016-6]
  5. CNPq [308053/2017-6]

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This case study investigated the treatment of glioblastoma in a 25-year-old female patient with a dendritic-tumor cell fusion vaccine. The findings suggest that tumor-specific CD4+ T-cell numbers and phenotype could serve as biomarkers for treatment efficacy.
Immunotherapy has brought hope to the fight against glioblastoma, but its efficacy remains unclear. We present the case of CST, a 25-year-old female patient with a large right-hemisphere glioblastoma treated with a dendritic-tumor cell fusion vaccine. CST showed a near-complete tumor response, with a marked improvement in her functional status and simultaneous increases in tumor-specific CD8+ and CD4+ T cells. Two months before recurrence, the frequency of tumor-specific T cells decreased, while that of IL-17 and CD4+ T cells increased. CST passed away 15 months after enrollment. In this illustrative case, the tumor-specific CD4+ T-cell numbers and phenotype behaved as treatment efficacy biomarkers, highlighting the key role of the latter in glioblastoma immunotherapy.

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