☆ 4.7 Article

Coagulopathy and Fibrinolytic Pathophysiology in COVID-19 and SARS-CoV-2 Vaccination

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination

Andreas Greinacher et al.

Summary: After vaccination with ChAdOx1 nCov-19, rare immune thrombotic thrombocytopenia can occur due to platelet-activating antibodies against PF4, resulting in various thrombotic events. Most patients in this case series were women, with fatal outcomes such as cerebral venous thrombosis and intracranial hemorrhage. Additional studies are needed to further investigate and understand this phenomenon.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Editorial Material Medicine, General & Internal

Thrombosis after covid-19 vaccination These rare events must not derail vaccination efforts

Paul R. Hunter

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Peripheral Vascular Disease

Blue Rubber Bleb Nevus Syndrome Complicated by Enhanced-Fibrinolytic-Type DIC: A Case Report

Shinya Yamada et al.

Summary: A 54-year-old Japanese man diagnosed with blue rubber bleb nevus syndrome (BRBNS) was treated with a combination therapy of apixaban and tranexamic acid for small bowel bleeding and enhanced-fibrinolytic-type DIC, which showed significant improvement. It is important to consider treatment strategies after performing detailed coagulation tests in patients with BRBNS.

ANNALS OF VASCULAR DISEASES (2021)

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Review Critical Care Medicine

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

Marcin F. Osuchowski et al.

Summary: The zoonotic SARS-CoV-2 virus causing COVID-19 has devastating consequences worldwide, affecting primarily the respiratory system but also leading to long-term complications. Understanding the pathophysiology and immune response of COVID-19 is crucial for optimizing patient care and treatment strategies.

LANCET RESPIRATORY MEDICINE (2021)

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Review Critical Care Medicine

Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into context

Federico Angriman et al.

Summary: The studies on IL-6 receptor antagonists show clinical and methodological heterogeneity, which may have led to apparently inconsistent results due to factors such as timing from clinical presentation to treatment, severity of illness, and concomitant use of corticosteroids.

LANCET RESPIRATORY MEDICINE (2021)

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Editorial Material Critical Care Medicine

Vascular mechanisms and manifestations of COVID-19

Marcel Levi et al.

LANCET RESPIRATORY MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Laboratory Monitoring of Direct Oral Anticoagulants (DOACs)

Claire Dunois

Summary: Direct oral anticoagulants (DOACs) provide a safe and effective alternative to previous anticoagulant therapies by directly, selectively, and reversibly inhibiting factors IIa or Xa. They have predictable pharmacokinetic and pharmacodynamic responses at a fixed dose, eliminating the need for monitoring. Testing may be helpful for patient management in specific clinical situations and for particular patient populations.

BIOMEDICINES (2021)

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Article Health Care Sciences & Services

A Rare Case of Cerebral Venous Thrombosis and Disseminated Intravascular Coagulation Temporally Associated to the COVID-19 Vaccine Administration

Vincenzo D'Agostino et al.

Summary: The global confirmed COVID-19 cases and deaths continue to increase, while vaccination efforts are progressing in different countries. Italy suspended the use of the AstraZeneca vaccine, but the European Medicines Agency concluded that the benefits of the vaccine outweigh the risks. A patient who developed severe thrombosis after vaccination ultimately died in intensive care.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Letter Hematology

Cerebral venous thrombosis post BNT162b2 mRNA SARS-CoV-2 vaccination: A black swan event

Bingwen Eugene Fan et al.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

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Article Medicine, General & Internal

Haematuria, a widespread petechial rash, and headaches following the Oxford AstraZeneca ChAdOx1 nCoV-19 Vaccination

Ammar Waraich et al.

Summary: This case report describes one of the earliest proven cases of vaccine-induced thrombotic thrombocytopenia (VITT) following COVID-19 vaccination in the UK. The patient, a 48-year-old man, presented with symptoms including frank hematuria, a widespread petechial rash, and headaches after receiving the Oxford AstraZeneca vaccine. The diagnosis of VITT should be based on platelet count and imaging, and patients with VITT require care in centers with urgent neurosurgical and interventional radiology services.

BMJ CASE REPORTS (2021)

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Article Hematology

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know

Gowthami M. Arepally et al.

BLOOD (2021)

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Article Hematology

Postdischarge thromboembolic outcomes and mortality of hospitalized patients with COVID-19: the CORE-19 registry

Dimitrios Giannis et al.

Summary: Thromboembolic events and mortality from subclinical thrombotic events frequently occur in COVID-19 inpatients. Postdischarge VTE, ATE, and ACM are common, with advanced age and cardiovascular risk factors increasing the risk. Postdischarge anticoagulation can significantly reduce the risk by 46%.

BLOOD (2021)

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Article Hematology

Immune thrombocytopenic purpura after vaccination with COVID-19 vaccine (ChAdOx1 nCov-19)

Finn-Ole Paulsen et al.

BLOOD (2021)

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Letter Hematology

Safety of anti-SARS-CoV-2 vaccination for patients with immune thrombocytopenia

Etienne Crickx et al.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

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Article Hematology

Exacerbation of immune thrombocytopenia following COVID-19 vaccination

David J. Kuter

Summary: A study found that COVID-19 vaccination may have varying effects on ITP patients, with some experiencing significant platelet count drops and new bleeding symptoms post-vaccination, but platelets recovered after rescue treatment.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Predictors of mortality in thrombotic thrombocytopenia after adenoviral COVID-19 vaccination: the FAPIC score

Jimin Hwang et al.

Summary: Fibrinogen levels, age, platelet count, and the presence of intracerebral hemorrhage and cerebral venous thrombosis were found to be significantly associated with mortality in adenoviral vaccine-associated thrombosis with thrombocytopenia syndrome (TTS). The newly developed FAPIC scoring system incorporating these risk factors showed promising predictive value for mortality in patients with TTS.

EUROPEAN HEART JOURNAL (2021)

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Letter Medicine, General & Internal

Primary adrenal insufficiency associated with Oxford-AstraZeneca ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia (VITT)

Jose F. Varona et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2021)

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Article Hematology

Hemophagocytic histiocytosis in severe SARS-CoV-2 infection: A bone marrow study

Himanshu Dandu et al.

Summary: Patients with severe COVID-19 infection may exhibit clinical and laboratory features similar to HLH, including fever, cytopenias, and hyperferritinemia. However, there are also differences such as lymphocytopenia and hyperfibrinogenemia in COVID-19 patients compared to HLH. Early recognition and further investigation may be crucial for appropriate management in suspected cases.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2021)

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Review Hematology

Laboratory testing for suspected COVID-19 vaccine-induced (immune) thrombotic thrombocytopenia

Emmanuel J. Favaloro

Summary: The COVID-19 pandemic has led to the production of vaccines to prevent infection, but there have been reports of rare thrombotic events post vaccination, particularly with adenovirus-based vaccines. Different terms have been used to describe this vaccine-induced condition, and testing methods vary, leading to potential differences in patient identification.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2021)

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Article Biochemistry & Molecular Biology

Severe COVID-19 Patients Show an Increase in Soluble TNFR1 and ADAM17, with a Relationship to Mortality

Yadira Palacios et al.

Summary: The study showed that solTNFR1 and solTNFR2 levels were elevated in COVID-19 patients without increasing transcriptional levels. SolTNFR1 was higher in severe cases and had a negative correlation with C-reactive protein, suggesting it as a potential therapeutic target. SolADAM17 levels were also higher in severe conditions, with a potential association between TNFRSF1A:rs767455 polymorphism and disease severity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Letter Oncology

Hemophagocytic lymphohistiocytosis after COVID-19 vaccination

Liang V. Tang et al.

Summary: This is the first reported case of a healthy individual developing hemophagocytic lymphohistiocytosis (HLH) after receiving the COVID-19 vaccine. The patient's symptoms gradually improved after treatment. The study suggests that excluding the presence of active EBV infection or other common viruses before COVID-19 vaccination is crucial.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Neurosciences

Vaccine-Induced Immune Thrombotic Thrombocytopenia with Disseminated Intravascular Coagulation and Death following the ChAdOx1 nCoV-19 Vaccine

Yasser Aladdin et al.

Summary: COVID-19 is not only a respiratory disease but also involves complications in other organs, necessitating the urgent development of effective vaccines to control its global spread.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

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Article Neurosciences

Cerebral Venous Thrombosis after BNT162b2 mRNA SARS-CoV-2 vaccine

Leonor Dias et al.

Summary: Concerns have been raised about venous thromboembolism, specifically cerebral venous thrombosis, following the development of SARS-CoV-2 vaccines. While cases of cerebral venous thrombosis have been reported after viral vector vaccine administration, two cases of cerebral venous thrombosis following mRNA vaccine administration did not exhibit thrombocytopenia or anti platelet antibodies. This suggests that the pathophysiology of these cases may not differ significantly from cerebral venous thrombosis not associated with SARS-CoV-2 vaccination.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

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Review Clinical Neurology

Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-19 vaccination; a systematic review

Maryam Sharifian-Dorche et al.

Summary: CVST and VITT are rare but severe complications following COVID-19 vaccination, with most patients being female. Symptoms typically occur within one week after vaccination, with headache being the primary presenting symptom. Some patients may experience serious complications such as intracerebral hemorrhage.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2021)

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Article Hematology

Imbalance of von Willebrand factor and ADAMTS13 axis is rather a biomarker of strong inflammation and endothelial damage than a cause of thrombotic process in critically ill COVID-19 patients

Berangere S. Joly et al.

Summary: Clinical features, hemostatic laboratory parameters, VWF/ADAMTS13 axis, and ADAMTS13 conformation were investigated in critically ill COVID-19 patients at admission. The study found that an imbalance between high VWF antigen levels and normal or slightly decreased ADAMTS13 activity levels correlated with mortality, suggesting that these markers may reflect inflammation and endothelial damage rather than driving the thrombotic process of COVID-19.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Hematology

Use of novel antithrombotic agents for COVID-19: Systematic summary of ongoing randomized controlled trials

Azita H. Talasaz et al.

Summary: Studies on antithrombotic agents in COVID-19 patients suggest that traditional medications may not be effective, prompting research on novel agents with anti-inflammatory and antiviral effects to improve patient outcomes.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Hematology

Platelets contribute to disease severity in COVID-19

Tessa J. Barrett et al.

Summary: Platelet count, size, and maturity are associated with increased critical illness and all-cause mortality among hospitalized COVID-19 patients. SARS-CoV-2 virions enter megakaryocytes and platelets in COVID-19 patients, leading to alterations in the platelet transcriptome and activation profile. In vitro mechanistic studies show that the interaction of SARS-CoV-2 with megakaryocytes causes distinct effects on platelets compared to the coronavirus responsible for the common cold (CoV-OC43).

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Hematology

Acquired thrombotic thrombocytopenic purpura: A rare disease associated with BNT162b2 vaccine

Hannah Maayan et al.

Summary: This study presents a case series of patients who developed acquired Thrombotic Thrombocytopenic Purpura shortly after receiving the BNT162b2 vaccine. It recommends evaluating ADAMTS13 activity in patients with a history of aTTP before and after vaccination, especially with the SARS-CoV-2 vaccine. Close monitoring of patients' clinical situation and laboratory data post-vaccination is essential.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Hematology

Association of prehospital antiplatelet therapy with survival in patients hospitalized with COVID-19: A propensity score-matched analysis

Jonathan H. Chow et al.

Summary: A large observational study of COVID-19 patients found that prehospital antiplatelet therapy was associated with significantly lower in-hospital mortality. The study suggests that further randomized controlled trials are needed to determine the ultimate utility of antiplatelet therapy in COVID-19 patients with high rates of comorbidities.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Hematology

First report of a de novo iTTP episode associated with an mRNA-based anti-COVID-19 vaccination

Severine de Bruijn et al.

Summary: This case report describes a 38-year-old woman who developed de novo iTTP after receiving an mRNA-based COVID-19 vaccine. She presented with skin bruising and petechiae 2 weeks after vaccination. Treatment with plasma exchange, corticosteroids, rituximab, and caplacizumab was successful in managing her condition.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Cardiac & Cardiovascular Systems

Immature platelets in patients with Covid-19: association with disease severity

Amir Cohen et al.

Summary: The study found that the proportion of circulating immature platelets is associated with disease severity in Covid-19 patients, with patients who have severe disease showing significantly higher levels of immature platelets compared to those with mild to moderate disease.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

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Article Virology

Direct Activation of Endothelial Cells by SARS-CoV-2 Nucleocapsid Protein Is Blocked by Simvastatin

Yisong Qian et al.

Summary: Evidence suggests that SARS-CoV-2's NP significantly activates human endothelial cells through TLR2/NF-κB and MAPK signaling pathways, with simvastatin identified as a potential inhibitor. This study provides insights on COVID-19-induced vasculopathy and coagulopathy, emphasizing the importance of understanding the mechanistic role of vasculature in these patients.

JOURNAL OF VIROLOGY (2021)

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Article Medicine, General & Internal

Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial

Renato D. Lopes et al.

Summary: In hospitalized COVID-19 patients with elevated D-dimer concentration, in-hospital therapeutic anticoagulation with rivaroxaban or enoxaparin followed by rivaroxaban to day 30 did not improve clinical outcomes and increased bleeding compared with prophylactic anticoagulation. Therapeutic-dose rivaroxaban and other direct oral anticoagulants should be avoided in these patients without an evidence-based indication for oral anticoagulation.

LANCET (2021)

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News Item Multidisciplinary Sciences

HOW THE CORONAVIRUS INFECTS OUR CELLS

Megan Scudellari

NATURE (2021)

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Letter Medicine, General & Internal

Vaccine-Induced Thrombocytopenia with Severe Headache

Farid Salih et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Hematology

PF4-Dependent Immunoassays in Patients with Vaccine-Induced Immune Thrombotic Thrombocytopenia: Results of an Interlaboratory Comparison

Ulrich J. Sachs et al.

Summary: The study suggests that functional antibody testing can confirm vaccine-induced thrombotic thrombocytopenia (VITT). ELISA is the most sensitive detection method, while PaGIA, LFA, and CLIA may not be effective when used alone for screening suspected cases.

THROMBOSIS AND HAEMOSTASIS (2021)

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Article Immunology

High Prevalence of Anti-PF4 Antibodies Following ChAdOx1 nCov-19 (AZD1222) Vaccination Even in the Absence of Thrombotic Events

Evangelos Terpos et al.

Summary: The study found that the ChAdOx1 nCov-19 vaccine can generate anti-PF4 antibodies in recipients even without thrombotic symptoms, but these antibodies are not enough to cause clinically evident thrombosis. This insight into the multifactorial pathophysiology of thrombotic events induced by the ChAdOx1 nCov-19 vaccine is crucial for ongoing investigations.

VACCINES (2021)

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Article Medicine, General & Internal

Upregulation of pulmonary tissue factor, loss of thrombomodulin and immunothrombosis in SARS-CoV-2 infection

Ivo M. B. Francischetti et al.

Summary: This study found that COVID-19 patients have thrombotic and microvascular complications, and the coagulation abnormalities have a multifactorial etiology. Biomarkers of endothelial cell, neutrophil activation, and fibrinolysis were elevated in severe disease group, correlating with severity. Postmortem specimens demonstrated potential links to immunothrombosis with upregulation of pulmonary TF and loss of thrombomodulin staining.

ECLINICALMEDICINE (2021)

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Article Medicine, General & Internal

Cerebral Venous Sinus Thrombosis After BNT162b2 mRNA COVID-19 Vaccination

Yoshitaka Yamaguchi et al.

Summary: This study presents a rare case of cerebral venous sinus thrombosis following the BNT162b2 mRNA COVID-19 vaccine in a 61-year-old Japanese man. The patient developed a headache 10 days after vaccination, was treated and discharged without any neurological sequelae, showing improvement in symptoms.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Article Medicine, General & Internal

Nafamostat in hospitalized patients with moderate to severe COVID-19 pneumonia: a randomised Phase II clinical trial

Sergey Zhuravel et al.

Summary: The study found no significant difference in the time to clinical improvement between the nafamostat and standard-of-care groups for COVID-19 pneumonia patients overall, but nafamostat showed a significantly shorter time to clinical improvement in a small subgroup of high-risk patients requiring oxygen treatment.

ECLINICALMEDICINE (2021)

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Letter Clinical Neurology

Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination

Yasemin Goereci et al.

Summary: Two cases of major arterial occlusions after ChAdOx1 nCov-19 vaccination were successfully treated with intravenous immunoglobulins and non-heparin anticoagulant agents, leading to a beneficial short-term outcome in both cases.

NEUROLOGICAL RESEARCH AND PRACTICE (2021)

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Article Medicine, General & Internal

Intracerebral Hemorrhage and Thrombocytopenia After AstraZeneca COVID-19 Vaccine: Clinical and Diagnostic Challenges of Vaccine-Induced Thrombotic Thrombocytopenia

Floor N. H. Wilting et al.

Summary: VITT is a rare prothrombotic disorder associated with COVID-19 vaccines, diagnosed by detecting anti-PF4 antibodies. Severe complications like intracerebral hemorrhage and thrombocytopenia may occur.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Article Medicine, General & Internal

Aspirin Is Related to Worse Clinical Outcomes of COVID-19

Isaac Kim et al.

Summary: The study found that aspirin use was associated with adverse effects in COVID-19 patients, with aspirin use before COVID-19 related to increased death rates and aspirin use after COVID-19 related to a higher risk of requiring conventional oxygen therapy. Further studies on the mechanisms are needed.

MEDICINA-LITHUANIA (2021)

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Review Pathology

COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury

Roberto F. Nicosia et al.

Summary: Critically ill COVID-19 patients develop vascular complications characterized by thrombosis in blood vessels of various sizes. Dysfunction of the vascular endothelium is mainly due to the indirect effects of the virus through cytokine storms and excessive immune response, rather than direct viral entry and infection of endothelial cells.

AMERICAN JOURNAL OF PATHOLOGY (2021)

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Article Respiratory System

Post-anticoagulant D-dimer is a highly prognostic biomarker of COVID-19 mortality

Xiaoyu Song et al.

Summary: This study found that changes in D-dimer levels following anticoagulation treatment are independently predictive of in-hospital mortality in severe COVID-19 patients. Patients were categorized based on their D-dimer level trends post-anticoagulation, with the high-increase group showing the highest mortality rate.

ERJ OPEN RESEARCH (2021)

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Review Hematology

Pathophysiology of Coagulopathy in Hematological Malignancies and in COVID-19

Marcel Levi

Summary: Severe illnesses may activate coagulation systemically, leading to a coagulopathy. While malignancies and COVID-19 display differing pathogenetic routes for coagulation abnormalities, they share the common feature of systemic impacts on coagulation. Malignancies are associated with venous thromboembolism due to tissue factor-mediated activation of coagulation, while COVID-19 induces a coagulopathy that is not identical to disseminated intravascular coagulation and thrombotic microangiopathy.

HEMASPHERE (2021)

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Article Hematology

Management of disseminated intravascular coagulation associated with aortic aneurysm and vascular malformations

Shinya Yamada et al.

Summary: Aortic aneurysms and vascular malformations are often associated with disseminated intravascular coagulation (DIC), which can be indicated by abnormal blood coagulation tests. Treatment for DIC focuses on addressing the underlying disease, and pharmacotherapy is often necessary in cases with bleeding and surgery is not an option.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2021)

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Review Hematology

COVID-19-associated coagulopathy and disseminated intravascular coagulation

Hidesaku Asakura et al.

Summary: The pathology of COVID-19 is exacerbated by thrombosis, DIC, and cytokine storms. D-dimer levels are commonly elevated in COVID-19, but relying solely on this marker has limitations. Treatment should be individualized based on disease severity and stage, with potential for combination therapy using heparin and nafamostat in the future. Further research is needed on fibrinolytic therapy and adsorption therapy.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2021)

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Article Hematology

Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

Ning Tang et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Medicine, General & Internal

Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome Results From a Prospective, Single-Center, Clinicopathologic Case Series

Sigurd F. Lax et al.

ANNALS OF INTERNAL MEDICINE (2020)

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Letter Microbiology

Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19

Markus Hoffmann et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

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Article Pharmacology & Pharmacy

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furinlike cleavage site absent in CoV of the same clade

B. Coutard et al.

ANTIVIRAL RESEARCH (2020)

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Letter Hematology

Association between ABO blood groups and risk of SARS-CoV-2 pneumonia

Juyi Li et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

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Review Critical Care Medicine

Coagulopathy of Coronavirus Disease 2019

Toshiaki Iba et al.

CRITICAL CARE MEDICINE (2020)

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Article Infectious Diseases

Association of inflammatory markers with the severity of COVID-19: A meta-analysis

Furong Zeng et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Allergy

Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan

Xiaochen Li et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Review Immunology

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

Betsy J. Barnes et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Medicine, General & Internal

Plasminogen improves lung lesions and hypoxemia in patients with COVID-19

Y. Wu et al.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2020)

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Letter Hematology

D-dimer is Associated with Severity of Coronavirus Disease 2019: A Pooled Analysis

Giuseppe Lippi et al.

THROMBOSIS AND HAEMOSTASIS (2020)

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Editorial Material Dermatology

A dermatologic manifestation of COVID-19: Transient livedo reticularis

Iviensan F. Manalo et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Letter Dermatology

Characterization of acute acral skin lesions in nonhospitalized patients: A case series of 132 patients during the COVID-19 outbreak

Diego Fernandez-Nieto et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Letter Dermatology

Cutaneous manifestations in COVID-19: a first perspective

S. Recalcati

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

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Article Hematology

Tissue plasminogen activator (tPA) treatment for COVID-19 associated acute respiratory distress syndrome (ARDS): A case series

Janice Wang et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Hematology

Direct oral anticoagulant plasma levels' striking increase in severe COVID-19 respiratory syndrome patients treated with antiviral agents: The Cremona experience

Sophie Testa et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Letter Hematology

Potential of heparin and nafamostat combination therapy for COVID-19

Hidesaku Asakura et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Hematology

D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19

Litao Zhang et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Review Hematology

Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID-19

Claire S. Whyte et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Letter Cardiac & Cardiovascular Systems

Pulmonary intravascular coagulation in COVID-19: possible pathogenesis and recommendations on anticoagulant/thrombolytic therapy

F. Burcu Belen-Apak et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2020)

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Article Cardiac & Cardiovascular Systems

Venous thrombosis and arteriosclerosis obliterans of lower extremities in a very severe patient with 2019 novel coronavirus disease: a case report

Bo Zhou et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2020)

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Article Critical Care Medicine

Early outcomes with utilization of tissue plasminogen activator in COVID-19-associated respiratory distress: A series of five cases

D. Benjamin Christie et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2020)

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Article Surgery

Acute limb ischemia in patients with COVID-19 pneumonia

Raffaello Bellosta et al.

JOURNAL OF VASCULAR SURGERY (2020)

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Article Medicine, General & Internal

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

Chaomin Wu et al.

JAMA INTERNAL MEDICINE (2020)

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Letter Medicine, General & Internal

Endothelial cell infection and endotheliitis in COVID-19

Zsuzsanna Varga et al.

LANCET (2020)

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Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

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Letter Emergency Medicine

Salvage use of tissue plasminogen activator (tPA) in the setting of acute respiratory distress syndrome (ARDS) due to COVID-19 in the USA: a Markov decision analysis

Rashikh Choudhury et al.

WORLD JOURNAL OF EMERGENCY SURGERY (2020)

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Editorial Material Critical Care Medicine

Increased cardiovascular mortality in African Americans with COVID-19

Dennis McGonagle et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Critical Care Medicine

Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans

Sharon E. Fox et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Multiorgan and Renal Tropism of SARS-CoV-2

Victor G. Puelles et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Letter Critical Care Medicine

Single-Cell RNA Expression Profiling of ACE2, the Receptor of SARS-CoV-2

Yu Zhao et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Article Medicine, General & Internal

Von Willebrand factor (vWF): marker of endothelial damage and thrombotic risk in COVID-19?

Eleni E. Ladikou et al.

CLINICAL MEDICINE (2020)

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Review Pharmacology & Pharmacy

Inhibition of SARS-CoV-2 entry through the ACE2/TMPRSS2 pathway: a promising approach for uncovering early COVID-19 drug therapies

Georgia Ragia et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2020)

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Article Hematology

Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome

Elizabeth A. Middleton et al.

BLOOD (2020)

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Article Hematology

Postdischarge venous thromboembolism following hospital admission with COVID-19

Lara N. Roberts et al.

BLOOD (2020)

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Article Hematology

Postdischarge thrombosis and hemorrhage in patients with COVID-19

Rushad Patell et al.

BLOOD (2020)

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Article Hematology

Complete hemostasis achieved by factor XIII concentrate administration in a patient with bleeding after teeth extraction as a complication of aplastic anemia and chronic disseminated intravascular coagulation

Shinya Yamada et al.

BLOOD COAGULATION & FIBRINOLYSIS (2020)

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Article Dermatology

SARS-CoV-2 endothelial infection causes COVID-19 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatric cases

I. Colmenero et al.

BRITISH JOURNAL OF DERMATOLOGY (2020)

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D-Dimer and Prothrombin Time Are the Significant Indicators of Severe COVID-19 and Poor Prognosis

Hui Long et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Low ADAMTS 13 plasma levels are predictors of mortality in COVID-19 patients

Mario Bazzan et al.

INTERNAL AND EMERGENCY MEDICINE (2020)

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Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID-19: a retrospective cohort study

Danying Liao et al.

LANCET HAEMATOLOGY (2020)

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Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

George Goshua et al.

LANCET HAEMATOLOGY (2020)

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Editorial Material Hematology

Coagulation abnormalities and thrombosis in patients with COVID-19

Marcel Levi et al.

LANCET HAEMATOLOGY (2020)

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Prognostic value of interleukin-6, C -reactive protein, patients with COVID-19 and procalcitonin in

Fang Liu et al.

JOURNAL OF CLINICAL VIROLOGY (2020)

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The spectrum of COVID-19-associated dermatologic manifestations: An international registry of 716 patients from 31 countries

Esther E. Freeman et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Chilblain-like acral lesions during the COVID-19 pandemic (COVID): Histologic, immunofluorescence, and immunohistochemical study of 17 cases

Jean Kanitakis et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Letter Dermatology

Outbreak of chilblain-like acral lesions in children in the metropolitan area of Milan, Italy, during the COVID-19 pandemic

Cristiana Colonna et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Antiphospholipid antibodies in patients with COVID-19: A relevant observation?

Katrien M. J. Devreese et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study

Luca Carsana et al.

LANCET INFECTIOUS DISEASES (2020)

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The role of biomarkers in diagnosis of COVID-19-A systematic review

Muhammed Kermali et al.

LIFE SCIENCES (2020)

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SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

Jessie Huang et al.

CELL STEM CELL (2020)

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SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

Kizzmekia S. Corbett et al.

NATURE (2020)

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Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults

Mark J. Mulligan et al.

NATURE (2020)

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Association between antithrombin and mortality in patients with COVID-19. A possible link with obesity

Carmine Gazzaruso et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2020)

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AN OUNCE OF PREVENTION MAY PREVENT HOSPITALIZATION

Andrew B. Barker et al.

PHYSIOLOGICAL REVIEWS (2020)

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Primary presentation of COVID-19 solely with gastrointestinal symptoms: a problem for the containment of the disease

Christoph G. Dietrich et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2020)

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Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis

F. A. Klok et al.

THROMBOSIS RESEARCH (2020)

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The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner

Mizuki Yamamoto et al.

VIRUSES-BASEL (2020)

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Why misinterpretation of electron micrographs in SARS-CoV-2-infected tissue goes viral

Carsten Dittmayer et al.

LANCET (2020)

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CONSIDERATION OF TRANEXAMIC ACID ADMINISTRATION TO COVID-19 PATIENTS

Haruhiko Ogawa et al.

PHYSIOLOGICAL REVIEWS (2020)

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ANTI-PROTEASE TREATMENTS TARGETING PLASMIN(OGEN) AND NEUTROPHIL ELASTASE MAY BE BENEFICIAL IN FIGHTING COVID-19

Alain R. Thierry

PHYSIOLOGICAL REVIEWS (2020)

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A Single-Cell RNA Expression Map of Human Coronavirus Entry Factors

Manvendra Singh et al.

CELL REPORTS (2020)

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Perspective on fibrinolytic therapy in COVID-19: the potential of inhalation therapy against suppressed-fibrinolytic-type DIC

Hidesaku Asakura et al.

JOURNAL OF INTENSIVE CARE (2020)

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Letter Hematology

D-dimer cut-off points and risk of venous thromboembolism in adult hospitalized patients with COVID-19

Justin J. Choi et al.

THROMBOSIS RESEARCH (2020)

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Overcoming bleeding events related to extracorporeal membrane oxygenation in COVID-19

Hidesaku Asakura et al.

LANCET RESPIRATORY MEDICINE (2020)

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Nafamostat mesylate-induced hyperkalemia in critically ill patients with COVID-19: Four case reports

Masaki Okajima et al.

WORLD JOURNAL OF CLINICAL CASES (2020)

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COVID-19: Poor outcomes in patients with zinc deficiency

Dinesh Jothimani et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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The values of coagulation function in COVID-19 patients

Xin Jin et al.

PLOS ONE (2020)

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Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia

Dennis McGonagle et al.

LANCET RHEUMATOLOGY (2020)

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Obesity as a predictor for a poor prognosis of COVID-19: A systematic review

Alice Tamara et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

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The unique characteristics of COVID-19 coagulopathy

Toshiaki Iba et al.

CRITICAL CARE (2020)

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Pathology and Pathogenesis of SARS-CoV-2 Associated with Fatal Coronavirus Disease, United States

Roosecelis B. Martines et al.

EMERGING INFECTIOUS DISEASES (2020)

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Anticoagulation Options for Coronavirus Disease 2019 (COVID-19)-Induced Coagulopathy

Alla Turshudzhyan

CUREUS JOURNAL OF MEDICAL SCIENCE (2020)

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Letter Immunology

Pulmonary Embolism and Increased Levels of D-Dimer in Patients with Coronavirus Disease

Daniel O. Griffin et al.

EMERGING INFECTIOUS DISEASES (2020)

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Nafamostat mesylate treatment in combination with favipiravir for patients critically ill with Covid-19: a case series

Kent Doi et al.

CRITICAL CARE (2020)

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A Case of COVID-19 Infection With Delayed Thromboembolic Complication on Warfarin

Alpana Garg et al.

CUREUS JOURNAL OF MEDICAL SCIENCE (2020)

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Acquired von Willebrand syndrome and impaired platelet function during venovenous extracorporeal membrane oxygenation: Rapid onset and fast recovery

Johannes Kalbhenn et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2018)

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Aortic Aneurysm-associated Disseminated Intravascular Coagulation that Responded Well to a Switch from Warfarin to Rivaroxaban

Yasuko Kadohira et al.

INTERNAL MEDICINE (2017)

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Early Diagnosis of Acquired von Willebrand Syndrome (AVWS) is Elementary for Clinical Practice in Patients Treated with ECMO Therapy

Johannes Kalbhenn et al.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2015)

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Selective Interaction of Heparin with the Variable Region 3 within Surface Glycoprotein of Laboratory-Adapted Feline Immunodeficiency Virus

Qiong-Ying Hu et al.

PLOS ONE (2014)

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Classifying types of disseminated intravascular coagulation: clinical and animal models

Hidesaku Asakura

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Platelet Factor 4/Heparin Antibodies in Blood Bank Donors

Marcie J. Hursting et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2010)

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Platelet factor 4/heparin antibody (IgG/M/A) in healthy subjects: a literature analysis of commercial immunoassay results

Gowthami M. Arepally et al.

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Suppression of RNA recognition by Toll-like receptors:: The impact of nucleoside modification and the evolutionary origin of RNA

K Karikó et al.

IMMUNITY (2005)

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Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

I Hamming et al.

JOURNAL OF PATHOLOGY (2004)

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Prevention of venous thromboembolism in the ICU

W Geerts et al.

CHEST (2003)

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The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity

AEI Proudfoot et al.

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