Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/ijms23073953
Keywords
coronavirus; host-virus interaction; autophagy; apoptosis; innate immunity
Funding
- Program of National Natural Science Foundation of China [32172824, 32102643]
- Key Research Projects of Universities in Guangdong Province [2019KZDXM026]
- Guangdong Major Project of Basic and Applied Basic Re-search [2020B0301030007]
- Key Realm R&D Program of Guangdong Province, China [2019B020211003]
- Outstanding Young Talents Project of South China Agricultural University
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This review summarizes recent advances in autophagy, apoptosis, and innate immunity induced by swine enteric coronavirus (SeCoV) infection, emphasizing their relationship with viral replication and signaling pathway alterations.
Swine enteric coronavirus (SeCoV) causes acute gastroenteritis and high mortality in newborn piglets. Since the last century, porcine transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV) have swept farms all over the world and caused substantial economic losses. In recent years, porcine delta coronavirus (PDCoV) and swine acute diarrhea syndrome coronavirus (SADS-CoV) have been emerging SeCoVs. Some of them even spread across species, which made the epidemic situation of SeCoV more complex and changeable. Recent studies have begun to reveal the complex SeCoV-host interaction mechanism in detail. This review summarizes the current advances in autophagy, apoptosis, and innate immunity induced by SeCoV infection. These complex interactions may be directly involved in viral replication or the alteration of some signal pathways.
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