Regulation of Cell-Signaling Pathways by Berbamine in Different Cancers

Natural product research is a cornerstone of the architectural framework of clinical medicine. Berbamine is a natural, potent, pharmacologically active biomolecule isolated from Berberis amurensis. Berbamine has been shown to modulate different oncogenic cell-signaling pathways in different cancers. In this review, we comprehensively analyze how berbamine modulates deregulated pathways (JAK/STAT, CAMKII/c-Myc) in various cancers. We systematically analyze how berbamine induces activation of the TGF/SMAD pathway for the effective inhibition of cancer progression. We also summarize different nanotechnological strategies currently being used for proficient delivery of berbamine to the target sites. Berbamine has also been reported to demonstrate potent anti-cancer and anti-metastatic effects in tumor-bearing mice. The regulation of non-coding RNAs by berbamine is insufficiently studied, and future studies must converge on the identification of target non-coding RNAs. A better understanding of the regulatory role of berbamine in the modulation of non-coding RNAs and cell-signaling pathways will be advantageous in the effective translation of laboratory findings to clinically effective therapeutics.

Automated summary

This article reviews the modulation mechanism of natural product berbamine in different cancers and oncogenic cell-signaling pathways. It also analyzes the activation of the TGF/SMAD pathway by berbamine and nanotechnological strategies for efficient delivery. Furthermore, berbamine demonstrates potent anti-cancer and anti-metastatic effects in tumor-bearing mice. However, the regulatory role of berbamine in non-coding RNAs remains insufficiently studied, and further research is needed.