Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ijms23094954
Keywords
urethane-dimethacrylates; quaternary ammonium compounds; photocurable copolymers; physicochemical properties; antibacterial activity
Funding
- Rector's grant for the scientific research and development activities in the Silesian University of Technology [04/040/BK22/0192]
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The physicochemical and antibacterial properties of six novel copolymers consisting of QAUDMA and TEGDMA were investigated. The copolymers exhibited low polymerization shrinkage, high degree of conversion, high glass transition temperature, and high antibacterial effectiveness against S. aureus and E. coli bacterial strains.
The growing scale of secondary caries and occurrence of antibiotic-resistant bacterial strains require the development of antibacterial dental composites. It can be achieved by the chemical introduction of quaternary ammonium dimethacrylates into dental composites. In this study, physicochemical and antibacterial properties of six novel copolymers consisting of 60 wt. % quaternary ammonium urethane-dimethacrylate analogues (QAUDMA) and 40 wt. % triethylene glycol dimethacrylate (TEGDMA) were investigated. Uncured compositions had suitable refractive index (RI), density (d(m)), and glass transition temperature (Tg(m)). Copolymers had low polymerization shrinkage (S), high degree of conversion (DC) and high glass transition temperature (Tg(p)). They also showed high antibacterial effectiveness against S. aureus and E. coli bacterial strains. It was manifested by the reduction in cell proliferation, decrease in the number of bacteria adhered on their surfaces, and presence of growth inhibition zones. It can be concluded that the copolymerization of bioactive QAUDMAs with TEGDMA provided copolymers with high antibacterial activity and rewarding physicochemical properties.
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