☆ 4.7 Article

Emerging Biomarkers of Multiple Sclerosis in the Blood and the CSF: A Focus on Neurofilaments and Therapeutic Considerations

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Related references

Note: Only part of the references are listed.

Article Biochemistry & Molecular Biology

Activation of Annexin A2 signaling at the blood-brain barrier in a mouse model of multiple sclerosis

Kenta Tezuka et al.

Summary: Blood-brain barrier (BBB) dysfunction is a fundamental cause of multiple sclerosis. In this study, protein expression at the BBB of experimental autoimmune encephalomyelitis (EAE) mice was comprehensively quantified using the SWATH method. The down-regulation of tight junction molecules and the up-regulation of molecules involved in cell infiltration and tight junction disruption, including ANXA2, were observed. Interestingly, daily administration of an ANXA2 inhibitor significantly suppressed the development of EAE in mice. These findings suggest that ANXA2 signaling plays an important role in the pathogenesis of EAE.

JOURNAL OF NEUROCHEMISTRY (2022)

Add to Collection

Article Clinical Neurology

Cerebrospinal fluid biomarkers and cognitive functions at multiple sclerosis diagnosis

Eleonora Virgilio et al.

Summary: Cognitive impairment is a common and disabling symptom in patients with multiple sclerosis. This study found that levels of Tau protein in cerebrospinal fluid may be related to cognitive impairment in the early stages, particularly in patients with slowed information processing speed.

JOURNAL OF NEUROLOGY (2022)

Add to Collection

Article Nutrition & Dietetics

BMI and Allostatic Load Are Directly Associated with Longitudinal Increase in Plasma Neurofilament Light among Urban Middle-Aged Adults

May A. Beydoun et al.

Summary: This study found associations between plasma neurofilament light chain (NfL) concentrations and cardiometabolic risk factors such as BMI and allostatic load, with potential differences by sex or race. Factors like BMI, high-sensitivity C-reactive protein (hsCRP), and serum total cholesterol were linked to faster increase in NfL concentrations over time, possibly mediated by glycated hemoglobin concentrations.

JOURNAL OF NUTRITION (2022)

Add to Collection

Review Immunology

Serum Based miRNA as a Diagnostic Biomarker for Multiple Sclerosis: a Systematic Review and Meta-Analysis

Samar A. Zailaie et al.

Summary: The systematic review and meta-analysis identified 19 serum miRNAs differentially expressed in multiple sclerosis patients, with 8 downregulated, 11 upregulated, and 1 discordant. The pooled AUC was 72% for overall MS patients and PPMS, indicating high sensitivity and specificity. A miRNA panel of four miRNAs showed high sensitivity (73%) and specificity (68%) in distinguishing MS from control groups.

IMMUNOLOGICAL INVESTIGATIONS (2022)

Add to Collection

Editorial Material Pharmacology & Pharmacy

Longitudinal Analysis Suggests Epstein--Barr as Cause of Multiple Sclerosis

[Anonymous]

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

Add to Collection

Article Clinical Neurology

Connection between microstructural alterations detected by diffusion MRI and cognitive dysfunction in MS: A model-free analysis approach

Peter Farago et al.

Summary: This study used a PLS approach to investigate the relationship between cognitive function and white matter microstructure in MS patients, revealing that different diffusion parameter patterns and spatial organizations were associated with specific cognitive tasks. Axial diffusivity alterations, potentially indicating irreversible axonal loss, explained a portion of the variability in cognitive functions.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

Add to Collection

Article Clinical Neurology

Factors contributing to CSF NfL reduction over time in those starting treatment for multiple sclerosis: An observational study

Ide Smets et al.

Summary: In patients with multiple sclerosis (MS), the decrease in cerebrospinal fluid (CSF) neurofilament light chain (NfL) levels is influenced by factors such as age, disability status, and MS type. However, other factors including BMI, disease duration, and sex do not have an impact on CSF NfL reduction.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

Add to Collection

Article Medicine, General & Internal

Brain Volume Loss Can Occur at the Rate of Normal Aging in Patients with Multiple Sclerosis Who Are Free from Disease Activity

Joke Temmerman et al.

Summary: This study suggests that neurodegeneration in multiple sclerosis (MS) can slow down to the rate of normal aging once inflammatory disease activity has been extinguished. Early introduction of high-efficacy disease-modifying treatment (DMT) is advocated to reduce the risk of future clinical disability.

JOURNAL OF CLINICAL MEDICINE (2022)

Add to Collection

Article Clinical Neurology

Assessing Neurofilaments as Biomarkers of Neuroprotection in Progressive Multiple Sclerosis From the MS-STAT Randomized Controlled Trial

Thomas E. Williams et al.

Summary: This study found no evidence of a significant impact of simvastatin treatment on serum neurofilaments. While confirmation of the neuroprotective benefits of simvastatin is awaited from the ongoing phase 3 study, our results suggest that treatments capable of slowing the rate of whole brain atrophy in SPMS, such as simvastatin, may act via mechanisms largely independent of neuroaxonal injury, as quantified by NfL.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2022)

Add to Collection

Article Engineering, Biomedical

Associations between neurofilament light chain levels, disease activity and brain atrophy in progressive multiple sclerosis

Jarmila Szilasiova et al.

Summary: This study found that plasma neurofilament light chain (pNfL) levels can serve as a biomarker for NEDA-3 status and brain MRI volumetry in patients with progressive MS.

BIOMEDICAL PAPERS-OLOMOUC (2022)

Add to Collection

Article Clinical Neurology

Exploring CSF neurofilament light as a biomarker for MS in clinical practice; a retrospective registry-based study

Igal Rosenstein et al.

Summary: This study validates the utility of cerebrospinal fluid NFL (cNFL) as a biomarker in clinical practice of relapsing-remitting multiple sclerosis (RRMS). cNFL can reliably diagnose disease activity, predict treatment response, disability, and conversion from RRMS to SPMS, suggesting its inclusion in the assessment of patients at MS onset.

MULTIPLE SCLEROSIS JOURNAL (2022)

Add to Collection

Article Clinical Neurology

Sustained reduction of serum neurofilament light chain over 7 years by alemtuzumab in early relapsing-remitting MS

Jens Kuhle et al.

Summary: The study evaluated serum neurofilament light chain (sNfL) levels in patients treated with alemtuzumab, showing that alemtuzumab was superior to subcutaneous interferon beta-1a (SC IFNB-1a) in reducing sNfL levels, with patients' levels remaining stable over seven years.

MULTIPLE SCLEROSIS JOURNAL (2022)

Add to Collection

Article Clinical Neurology

High or increasing serum NfL is predictive of impending multiple sclerosis relapses

Simon Thebault et al.

Summary: This study assessed the association between longitudinal changes in neurofilament light chain (sNfL) and future relapses in multiple sclerosis (MS), finding that long-term increases in sNfL levels were associated with an increased risk of relapse, especially in patients with lower baseline sNfL. These results help identify patients who would benefit from early treatment optimization.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

Add to Collection

Article Multidisciplinary Sciences

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

Kjetil Bjornevik et al.

Summary: This study suggests that multiple sclerosis may be caused by Epstein-Barr virus, with no direct association with other viral infections. These findings provide clues to the primary cause of MS.

SCIENCE (2022)

Add to Collection

Article Clinical Neurology

Serum NfL levels in the first five years predict 10-year thalamic fraction in patients with MS

Hrishikesh Lokhande et al.

Summary: This study investigated the association between early serum neurofilament light (sNfL) levels and 10-year regional brain volumes in multiple sclerosis (MS) patients. The findings suggest that early sNfL levels are correlated with thalamic volume after 10 years, indicating the potential value of sNfL as a prognostic biomarker in MS.

MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL (2022)

Add to Collection

Article Geriatrics & Gerontology

Neurofilament light chain concentration in an aging population

Aurelie Ladang et al.

Summary: In this study, we assessed the concentration of neurofilament light chain (NF-L) in the serum of 409 community-dwelling adults aged over 65 years. We found that NF-L concentration was associated with kidney function, age, and body mass index (BMI). Subjects with self-reported neurological disorders had higher NF-L concentration. Furthermore, NF-L concentration was also associated with cognitive impairment but not with depression. It is important to interpret NF-L measurements with caution, especially in patients with renal failure.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2022)

Add to Collection

Letter Clinical Neurology

CXCL13 Levels Indicate Treatment Responsiveness to Fingolimod in MS Patients

Zerrin Karaaslan et al.

EUROPEAN NEUROLOGY (2022)

Add to Collection

Article Clinical Neurology

Leptin levels are associated with multiple sclerosis risk

Martin Bistrom et al.

Summary: This study found that a 1-unit leptin z-score increase was associated with an increased risk of MS among individuals younger than 20 years and all men, while for women aged 30-39 years, increased leptin levels were associated with a lower risk of MS when adjusting for insulin levels.

MULTIPLE SCLEROSIS JOURNAL (2021)

Add to Collection

Review Clinical Neurology

Neurofilaments in progressive multiple sclerosis: a systematic review

Thomas Williams et al.

Summary: Neurofilament light is consistently associated with current inflammatory activity and future brain atrophy in progressive multiple sclerosis, and is consistently shown to be a marker of treatment response with immunosuppressive disease-modifying therapies. On the other hand, neurofilament heavy evidence is more limited and inconsistent.,UnityEngineNeither neurofilament light nor heavy has shown a consistent treatment response to neuroprotective disease-modifying therapies.

JOURNAL OF NEUROLOGY (2021)

Add to Collection

Article Clinical Neurology

Neurofilament levels are associated with blood-brain barrier integrity, lymphocyte extravasation, and risk factors following the first demyelinating event in multiple sclerosis

Tomas Uher et al.

Summary: This study found that during the first demyelinating event of multiple sclerosis (MS), levels of neurofilament light chain (NfL) were associated with greater impairment of blood brain barrier (BBB) integrity, immune cell extravasation, and brain lesion activity on magnetic resonance imaging (MRI).

MULTIPLE SCLEROSIS JOURNAL (2021)

Add to Collection

Article Clinical Neurology

Should I stop or should I go on? Disease modifying therapy after the first clinical episode of multiple sclerosis

Tobias Monschein et al.

Summary: In CIS patients with immediate DMT after their first clinical episode, older age at the time of DMT discontinuation is the main predictive factor for sustained NEDA status.

JOURNAL OF NEUROLOGY (2021)

Add to Collection

Article Clinical Neurology

Altered brain network function during attention-modulated visual processing in multiple sclerosis

Daniel Vereb et al.

Summary: This study found altered connectivity within attention-related networks in multiple sclerosis patients during task performance, which scales with cognitive disability.

MULTIPLE SCLEROSIS JOURNAL (2021)

Add to Collection

Article Clinical Neurology

Mild progressive multifocal leukoencephalopathy after switching from natalizumab to ocrelizumab

Alyssa A. Toorop et al.

Summary: Two patients with relapsing-remitting MS developed carryover PML after switching from natalizumab to ocrelizumab. Despite mild immune reconstitution inflammatory syndrome (IRIS) and increasing NfL levels, PML-IRIS lesions stabilized after treatment and both patients continued therapy with ocrelizumab.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

Add to Collection

Article Cell Biology

Factors influencing serum neurofilament light chain levels in normal aging

Marisa Koini et al.

Aging-US (2021)

Add to Collection

Review Endocrinology & Metabolism

A comprehensive review on the role of chemokines in the pathogenesis of multiple sclerosis

Soudeh Ghafouri-Fard et al.

Summary: Multiple sclerosis (MS) is considered to be a chronic inflammatory disorder of the central nervous system caused by abnormal immune responses. Chemokines play an important role in the pathogenesis of MS, with several members of this family being dysregulated in MS patients' peripheral blood, cerebrospinal fluid, or CNS lesions. Studies in animal models have shown the critical roles of chemokines in the pathophysiology of MS.

METABOLIC BRAIN DISEASE (2021)

Add to Collection

Article Clinical Neurology

Variations in consecutive serum neurofilament light levels in healthy controls and multiple sclerosis patients

C. Bridel et al.

Summary: The study suggests that variations in neurofilament light occur to a similar extent and magnitude in both healthy controls and multiple sclerosis populations. Changes between two consecutive neurofilament light measurements may reflect natural fluctuations rather than variations in inflammatory disease activity.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Add to Collection

Review Clinical Neurology

Anti-CD20 B Cell Treatment for Relapsing Multiple Sclerosis

Charles A. Roach et al.

Summary: Several clinical trials have shown the efficacy of lytic therapies targeting B cells in treating multiple sclerosis, particularly in the relapsing subtype. Modest efficacy has also been observed in the primary progressive subtype. The clinical success has sparked interest in the role of B cells in MS pathogenesis and ways to enhance current therapies.

FRONTIERS IN NEUROLOGY (2021)

Add to Collection

Article Clinical Neurology

Serum neurofilament levels and patient-reported outcomes in multiple sclerosis

Kristin Galetta et al.

Summary: In practice, serum neurofilament light is associated with health outcomes and healthcare utilization in multiple sclerosis patients.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2021)

Add to Collection

Article Clinical Neurology

Obesity and the risk of Multiple Sclerosis. The role of Leptin

Mariano Marrodan et al.

Summary: Obesity at a young age increases the risk of multiple sclerosis, and leptin levels are correlated with BMI. Leptin promotes autoreactive T-cell proliferation and proinflammatory cytokine secretion, while inhibiting Treg-cell proliferation.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2021)

Add to Collection

Article Clinical Neurology

High serum neurofilament associates with diffuse white matter damage in MS

Maija Saraste et al.

Summary: Elevated serum NfL in MS is associated with neuroaxonal damage in both NAWM and focal T2 lesions. Multiple regression analysis showed significant associations between diffusion tensor indices and NfL after adjusting for demographic and clinical factors.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

Add to Collection

Review Clinical Neurology

Apparent changes in the epidemiology and severity of multiple sclerosis

Nils Koch-Henriksen et al.

Summary: The incidence of MS appears to be increasing, but the disease has become milder. Understanding these trends and the reasons behind them is crucial for clinical management and treatment decisions.

NATURE REVIEWS NEUROLOGY (2021)

Add to Collection

Review Medicine, General & Internal

Diagnosis and Treatment of Multiple Sclerosis A Review

Marisa P. McGinley et al.

Summary: Multiple sclerosis is a neurodegenerative disease that affects the central nervous system, leading to physical disability, cognitive impairment and decreased quality of life. Current disease-modifying therapies can reduce relapse rates by 29% to 68% compared to placebo or active comparators.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Add to Collection

Article Clinical Neurology

Neurofilament light chain in a phase 2 clinical trial of ibudilast in progressive multiple sclerosis

Robert J. Fox et al.

Summary: This study aimed to evaluate the effect of ibudilast treatment on serum and cerebrospinal fluid (CSF) levels of neurofilament light (NfL) in progressive multiple sclerosis (MS). The results showed no significant difference in NfL levels in either serum or CSF between the treatment and placebo groups.

MULTIPLE SCLEROSIS JOURNAL (2021)

Add to Collection

Review Neurosciences

Neuronal and glial CSF biomarkers in multiple sclerosis: a systematic review and meta-analysis

Sara Momtazmanesh et al.

Summary: The meta-analysis found that levels of neuronal and glial biomarkers in the cerebrospinal fluid of multiple sclerosis patients varied in different groups, indicating the potential of these biomarkers in diagnosing MS and distinguishing different subtypes.

REVIEWS IN THE NEUROSCIENCES (2021)

Add to Collection

Article Clinical Neurology

A pharmacokinetic and biomarker study of delayed-release dimethyl fumarate in subjects with secondary progressive multiple sclerosis: evaluation of cerebrospinal fluid penetration and the effects on exploratory biomarkers

Keith R. Edwards et al.

Summary: This study investigated the pharmacokinetics of DMF in patients with secondary progressive MS and examined the correlation between CSF biomarker data and disease activity, suggesting that NfL and GFAP levels in CSF may be related to disease activity in pwSPMS. Further well-controlled studies are needed to confirm the potential benefits of DMF in reducing disease activity in pwSPMS.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Add to Collection

Review Clinical Neurology

A candidate biomarker of glial fibrillary acidic protein in CSF and blood in differentiating multiple sclerosis and its subtypes: A systematic review and meta-analysis

MengJiao Sun et al.

Summary: The study found that levels of CSF-GFAP are associated with MS and its different subtypes, reflecting varying degrees of astrocyte damage in different MS subtypes. Progressive MS is more closely linked to increased cerebrospinal fluid GFAP levels than relapsing-remitting MS, suggesting GFAP may be a useful marker of disease progression. Additionally, blood GFAP levels in MS patients are higher than those in the control group, warranting further verification with a larger sample size in the future.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Add to Collection

Article Clinical Neurology

CSF levels of HoxB3 and YKL-40 may predict conversion from clinically isolated syndrome to relapsing remitting multiple sclerosis

Yusuf Tamam et al.

Summary: Levels of HoxB3 and YKL-40 in CSF can predict conversion from CIS to MS, especially when used in combination. Lower CSF HoxB3 and higher CSF YKL-40 are associated with a faster progression to clinically definite MS.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Add to Collection

Article Multidisciplinary Sciences

Osteopontin levels are associated with late-time lower regional brain volumes in multiple sclerosis

Gergely Orsi et al.

Summary: OPN levels in the cerebrospinal fluid are associated with regional brain volumes and white matter lesions in patients with multiple sclerosis, showing a potential link between inflammation in the central nervous system and long-term brain alterations. Serum OPN, however, did not show a similar association with brain volumes.

SCIENTIFIC REPORTS (2021)

Add to Collection

Review Neurosciences

Long Non-coding RNAs and Circular RNAs: Insights Into Microglia and Astrocyte Mediated Neurological Diseases

Miaomiao Chen et al.

Summary: This review highlights the roles of lncRNAs and circRNAs in neurological diseases, emphasizing their importance in the functional changes of microglia and astrocytes, neuronal damage, and inflammation processes.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

Add to Collection

Article Clinical Neurology

Serum GFAP and NfL levels in benign relapsing-remitting multiple sclerosis

Marja Niiranen et al.

Summary: The study found significantly elevated serum GFAP levels in both BRRMS and ARRMS patients compared to healthy controls, with no significant differences between BRRMS and ARRMS. There were also no significant differences in serum NfL levels among the groups.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Add to Collection

Article Medicine, General & Internal

NfL predicts relapse-free progression in a longitudinal multiple sclerosis cohort study

Timo Uphaus et al.

Summary: This study found that sNfL levels at baseline predict relapse-free disability progression in patients with multiple sclerosis, and further discriminates patients with secondary progressive MS (SPMS) at follow-up.

EBIOMEDICINE (2021)

Add to Collection

Article Clinical Neurology

CSF Levels of CXCL12 and Osteopontin as Early Markers of Primary Progressive Multiple Sclerosis

Damiano Marastoni et al.

Summary: The study evaluated the extent of intrathecal inflammation in patients with PPMS and RRMS at diagnosis, identifying higher levels of CXCL12 and osteopontin in PPMS, and increased IL-10 levels in RRMS. Elevated CXCL12 levels were associated with gray matter lesion burden, indicating a potential role of brain innate immunity and glial activity in MS progression. This suggests that specific CSF protein profiles could help differentiate between PPMS and RRMS, and these molecules may serve as useful candidate markers for understanding and treating progressive MS.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

Add to Collection

Article Neurosciences

Health Economic Impact of Software-Assisted Brain MRI on Therapeutic Decision-Making and Outcomes of Relapsing-Remitting Multiple Sclerosis Patients-A Microsimulation Study

Diana M. Sima et al.

Summary: The study shows that using assistive MRI software for detecting and quantifying lesions and/or brain atrophy has a significant impact on disease activity detection, treatment decisions, health outcomes, utilities, and costs in multiple sclerosis patients. Results indicate that using software-assisted MRI compared to clinical parameters only can lead to better treatment outcomes and health economic benefits.

BRAIN SCIENCES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Profiling of Plasma Extracellular Vesicle Transcriptome Reveals That circRNAs Are Prevalent and Differ between Multiple Sclerosis Patients and Healthy Controls

Leire Iparraguirre et al.

Summary: This study characterized the EV RNA cargo of MS patients, focusing on circRNAs, and found significant differences in circRNA and linear RNA expression between MS patients and controls, as well as between different MS types, highlighting the importance of further understanding RNA regulation in MS.

BIOMEDICINES (2021)

Add to Collection

Article Neurosciences

Cerebrospinal Fluid Biomarkers of Myeloid and Glial Cell Activation Are Correlated With Multiple Sclerosis Lesional Inflammatory Activity

Ruturaj Masvekar et al.

Summary: Multiple sclerosis (MS)-related inflammation can be categorized into lesional and non-lesional activity, with IL12p40 and CHI3L1 identified as the best CSF biomarkers for measuring MS lesional activity. The study aims to develop a CSF-biomarker-based molecular surrogate for MS lesional activity.

FRONTIERS IN NEUROSCIENCE (2021)

Add to Collection

Article Clinical Neurology

Ultrasensitive immunoassay allows measurement of serum neurofilament heavy in multiple sclerosis

Inge M. W. Verberk et al.

Summary: The study found that serum NfH can be quantified using high-sensitivity technology, and demonstrated weak correlations with MS disease burden parameters in cross-sectional analysis, indicating potential utility as a biomarker for MS disease burden.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Add to Collection

Article Clinical Neurology

The Brain-Derived Neurotrophic Factor Val66Met Polymorphism Can Protect Against Cognitive Impairment in Multiple Sclerosis

Emilio Portaccio et al.

Summary: The study suggests a potential protective effect of BDNF Val66Met polymorphism against cognitive impairment in MS patients, possibly due to the detrimental effect of increased BDNF concentration in a neuroinflammatory environment. Higher EDSS score is associated with a progressive disease course, with a marginal association with the presence of the BDNF Val66Met polymorphism.

FRONTIERS IN NEUROLOGY (2021)

Add to Collection

Article Clinical Neurology

Natalizumab Pharmacokinetics and -Dynamics and Serum Neurofilament in Patients With Multiple Sclerosis

Undine Proschmann et al.

Summary: The study found that a portion of RRMS and SPMS patients experienced disease activity recurrence after discontinuing Natalizumab treatment. Concentrations of free and cell-bound Natalizumab, as well as alpha 4-integrin receptor saturation, decreased over time while alpha 4-integrin expression increased. sNfL levels were associated with disease activity recurrence and could serve as an early predictive marker.

FRONTIERS IN NEUROLOGY (2021)

Add to Collection

Article Clinical Neurology

Serum Neurofilament Levels and PML Risk in Patients With Multiple Sclerosis Treated With Natalizumab

Nicolas Fissolo et al.

Summary: This study demonstrates that serum neurofilament light chain levels can predict the risk of progressive multifocal leukoencephalopathy in patients with multiple sclerosis treated with natalizumab， and differentiate between PML and MS relapses.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

Add to Collection

Article Clinical Neurology

2021 MAGNIMS-CMSC-NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis

Mike P. Wattjes et al.

Summary: The 2021 revision of guidelines on MRI use for multiple sclerosis patients integrates recommendations from various organizations to improve the application of MRI for diagnosis, prognosis, and monitoring of individuals with multiple sclerosis. It suggests changes in MRI acquisition protocols, cautious use of gadolinium-based contrast agents, and extends recommendations to the use of MRI in children, during pregnancy, and in the post-partum period for patients with multiple sclerosis.

LANCET NEUROLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

A multicentre validation study of the diagnostic value of plasma neurofilament light

Nicholas J. Ashton et al.

Nature Communications (2021)

Add to Collection

Review Genetics & Heredity

Host Genetics and Gut Microbiome: Perspectives for Multiple Sclerosis

Alessandro Maglione et al.

Summary: Multiple Sclerosis (MS) is a complex disease determined by genetic and environmental factors, with the gut microbiome emerging as an important environmental factor. The interaction between the gut microbiome and host genetics in MS pathogenesis remains unclear. Research has focused on genetic factors, immune system interactions, and the gut microbiome in relation to MS, with future research avenues discussed.

GENES (2021)

Add to Collection

Article Clinical Neurology

Microstructural and functional brain abnormalities in multiple sclerosis predicted by osteopontin and neurofilament light

Gergely Orsi et al.

Summary: The study revealed that levels of osteopontin (OPN) in both serum and cerebrospinal fluid (CSF) are associated with lesion evolution, changes in normal-appearing white matter (NAWM) microstructure, and functional connectivity in multiple sclerosis (MS) patients. Additionally, neurofilament light chain (NFL) levels in CSF were associated with decreased connectivity strength, while OPN levels in the CSF were associated with increased connectivity strength, possibly indicating adaptive reorganization due to inflammatory white matter lesions and microstructural changes.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Add to Collection

Review Cell Biology

Neurofilament Light Chain (NfL) in Blood-A Biomarker Predicting Unfavourable Outcome in the Acute Phase and Improvement in the Late Phase after Stroke

Milos Pekny et al.

Summary: Research on monitoring blood NfL levels in stroke patients has shown that elevated levels are associated with poor clinical outcomes and can predict future functional improvement, but caution is needed in interpretation. NfL levels at different stages reflect various neurobiological processes.

CELLS (2021)

Add to Collection

Article Clinical Neurology

CSF Chitinase 3-Like 2 Is Associated With Long-term Disability Progression in Patients With Progressive Multiple Sclerosis

Manuel Comabella et al.

Summary: This study identified CHI3L2 as a potential protein biomarker associated with long-term disability progression in patients with progressive multiple sclerosis (MS) through shotgun proteomics analysis of cerebrospinal fluid. CHI3L2 levels showed good performance in discriminating between patients with high and low disability progression.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

Add to Collection

Article Clinical Neurology

Multiple Sclerosis circRNA Profile Defined Reveals Links to B-Cell Function

Anna E. Zurawska et al.

Summary: This study investigated the circRNA profile in RRMS patients and healthy controls, finding differential expression of circRNAs between patients in relapse and healthy controls. Some circRNAs were significantly upregulated during relapse and implicated in B-cell activity, potentially serving as a novel biomarker for monitoring RRMS relapse activity.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

Add to Collection

Article Clinical Neurology

Dimethyl Fumarate Treatment in Patients With Primary Progressive Multiple Sclerosis A Randomized, Controlled Trial

Helene Hojsgaard Chow et al.

Summary: The study found that dimethyl fumarate had no effect on NFL concentrations in the CSF of PPMS patients, while some other biomarkers may have changed in the treatment group. The treatment group had more side effects, but serious adverse events did not differ significantly between the two groups.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

Add to Collection

Article Clinical Neurology

CSF neurofilament light chain predicts 10-year clinical and radiologic worsening in multiple sclerosis

Alok Bhan et al.

Summary: The study found that baseline cerebrospinal fluid levels of neurofilament light chain were significantly associated with the clinical and radiological course of multiple sclerosis patients over a 10-year period, highlighting its importance as a prognostic marker.

MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL (2021)

Add to Collection

Article Clinical Neurology

Subcutaneous cladribine to treat multiple sclerosis: experience in 208 patients

Kimberley Allen-Philbey et al.

Summary: The study reported on the safety and effectiveness of subcutaneous cladribine in multiple sclerosis patients, showing that cladribine was generally well tolerated and effective in both relapsing and progressive MS patients, suggesting it may be a viable treatment option for MS patients at different disease stages.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2021)

Add to Collection

Article Medicine, Research & Experimental

Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma

Apeng Chen et al.

Summary: The CHI3L1 signaling pathway plays a crucial role in modulating the immune suppression microenvironment in glioblastoma by affecting tumor-associated macrophages. Gal3BP competes with Gal3 to bind CHI3L1, thus negatively regulating the immune evasion process. Administering a Gal3BP mimetic peptide in mouse models can reverse immune suppression and slow tumor progression.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Add to Collection

Article Medicine, General & Internal

YKL-40 promotes invasion and metastasis of bladder cancer by regulating epithelial mesenchymal transition

Hailong Hao et al.

Summary: The study aimed to investigate the relationship between YKL-40 and recurrence and progression of bladder cancer, and to determine its potential as a therapeutic target. Results showed that YKL-40 promoted migration and invasion of bladder cancer cells, with its expression closely linked to the invasiveness and metastasis of bladder cancer.

ANNALS OF MEDICINE (2021)

Add to Collection

Review Clinical Neurology

Correlation between CSF and blood neurofilament light chain protein: a systematic review and meta-analysis

Jasmini Alagaratnam et al.

Summary: The study assessed the correlation between CSF and blood NfL, showing moderate correlations, especially when blood NfL was measured using Simoa and ECL. ELISA resulted in weaker correlation.

BMJ NEUROLOGY OPEN (2021)

Add to Collection

Article Clinical Neurology

Neurofilament Light Chain Levels Are Associated with Disease Activity Determined by No Evident Disease Activity in Multiple Sclerosis Patients

Jarmila Szilasiova et al.

Summary: The study aimed to assess the relationship between plasma neurofilament light chain (pNfL) and disease activity in multiple sclerosis (MS) patients using the concept of no evident disease activity (NEDA). Results showed that pNfL levels are a useful biomarker of disease activity determined by NEDA status in MS patients and could be an alternative to brain magnetic resonance investigation.

EUROPEAN NEUROLOGY (2021)

Add to Collection

Review Neurosciences

miRNAs in Microglia: Important Players in Multiple Sclerosis Pathology

Alexander D. Walsh et al.

Summary: Microglia play a crucial role in maintaining the homeostasis of the central nervous system, with the potential to both benefit and harm CNS health depending on their phenotypes. Dysregulation of miRNAs can lead to aberrant activation of microglia and influence inflammation and neurodegeneration, with implications in MS pathogenesis. miRNAs are being explored as potential therapeutic targets to modulate microglial function and provide new approaches to treating MS.

ASN NEURO (2021)

Add to Collection

Article Biology

Depression and anxiety disorders in patients with multiple sclerosis: association with neurodegeneration and neurofilaments

C. B. Tauil et al.

Summary: NF-L levels are elevated in patients with MS and psychiatric disorders, but the relationship between depression and anxiety in RRMS-Fingo patients and NF-L levels is not statistically significant. MS events such as anxiety and depression may contribute to the onset of clinical relapses, subclinical cases, and neurodegeneration.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2021)

Add to Collection

Article Clinical Neurology

Chitinase 3-like 1 and neurofilament light chain in CSF and CNS atrophy in MS

Ruth Schneider et al.

Summary: CSF CHI3L1 is associated with spinal cord volume loss, less affected by disease duration and age compared to NfL, while CSF NfL is associated with brain gray matter atrophy. The measurement of CSF NfL and CHI3L1 provides complementary information on brain and spinal cord volumes.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

Add to Collection

Review Cell Biology

The Yin-Yang of osteopontin in nervous system diseases: damage versus repair

Giuseppe Cappellano et al.

Summary: Osteopontin is a pleiotropic protein that plays a role in the pathophysiology of various diseases, with studies showing its involvement in tissue damage and repair mechanisms in the context of neurological conditions. The dual roles of osteopontin in promoting tissue damage (Yin) and repair/regeneration (Yang) are mediated by different functional domains in its molecule, which activate intracellular signaling pathways and mediate cell interactions. Understanding these mechanisms could lead to the development of specific tools targeting this multifunctional protein.

NEURAL REGENERATION RESEARCH (2021)

Add to Collection

Article Immunology

Drug and Neurofilament Levels in Serum and Breastmilk of Women With Multiple Sclerosis Exposed to Natalizumab During Pregnancy and Lactation

Undine Proschmann et al.

Summary: This study observed women treated with natalizumab during pregnancy and lactation, finding that most patients did not experience disease activity during gestation and postpartum. Natalizumab concentration in breastmilk was low but detectable sNfL levels were present in most samples.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Clinical Neurology

Plasma neurofilaments correlate with disability in progressive multiple sclerosis patients

Diana Ferraro et al.

ACTA NEUROLOGICA SCANDINAVICA (2020)

Add to Collection

Article Clinical Neurology

Intrathecal immunoglobulins and neurofilament light after autologous haematopoietic stem cell transplantation for multiple sclerosis

Diane Larsson et al.

MULTIPLE SCLEROSIS JOURNAL (2020)

Add to Collection

Article Clinical Neurology

Serum Neurofilament Light Chain Levels in Patients With Presymptomatic Multiple Sclerosis

Kjetil Bjornevik et al.

JAMA NEUROLOGY (2020)

Add to Collection

Article Clinical Neurology

Vitamin D3 supplementation and neurofilament light chain in multiple sclerosis

Joost Smolders et al.

ACTA NEUROLOGICA SCANDINAVICA (2020)

Add to Collection

Article Clinical Neurology

MicroRNA profiles of MS gray matter lesions identify modulators of the synaptic protein synaptotagmin-7

Lena Fritsche et al.

BRAIN PATHOLOGY (2020)

Add to Collection

Article Clinical Neurology

Neurofilament light levels are associated with long-term outcomes in multiple sclerosis

Jens Kuhle et al.

MULTIPLE SCLEROSIS JOURNAL (2020)

Add to Collection

Article Neurosciences

Evaluation of plasma Osteopontin level in relapsing- remitting multiple sclerosis patients compared to healthy subjects in Isfahan Province

Morteza Jafarinia et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2020)

Add to Collection

Article Clinical Neurology

Serum glial fibrillary acidic protein correlates with multiple sclerosis disease severity

Heidi Hogel et al.

MULTIPLE SCLEROSIS JOURNAL (2020)

Add to Collection

Review Oncology

MicroRNAs in gray and white matter multiple sclerosis lesions: impact on pathophysiology

Sarah Teuber-Hanselmann et al.

JOURNAL OF PATHOLOGY (2020)

Add to Collection

Article Clinical Neurology

microRNA and exosome profiling in multiple sclerosis

Marcin P. Mycko et al.

MULTIPLE SCLEROSIS JOURNAL (2020)

Add to Collection

Article Clinical Neurology

Blood neurofilament light levels segregate treatment effects in multiple sclerosis

Benedicte Delcoigne et al.

NEUROLOGY (2020)

Add to Collection

Review Neurosciences

Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders

M. M. J. van den Berg et al.

PROGRESS IN NEUROBIOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Serum neurofilament light levels in normal aging and their association with morphologic brain changes

Michael Khalil et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Clinical Neurology

Identification and functional analysis of specific MS risk miRNAs and their target genes

Deling Luo et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2020)

Add to Collection

Article Clinical Neurology

Plasma copeptin levels in patients with multiple sclerosis

Mesrure Koseoglu et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2020)

Add to Collection

Article Clinical Neurology

Confounding effect of blood volume and body mass index on blood neurofilament light chain levels

Ali Manouchehrinia et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)

Add to Collection

Article Behavioral Sciences

Epidemiology of multiple sclerosis in Central Europe, update from Hungary

Tamas Biernacki et al.

BRAIN AND BEHAVIOR (2020)

Add to Collection

Article Clinical Neurology

Natural Variation of Vitamin D and Neurofilament Light Chain in Relapsing-Remitting Multiple Sclerosis

Egil Rosjo et al.

FRONTIERS IN NEUROLOGY (2020)

Add to Collection

Article Clinical Neurology

Validation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS

Michael Benatar et al.

NEUROLOGY (2020)

Add to Collection

Article Clinical Neurology

Exosomal neurofilament light: A prognostic biomarker for remote symptoms after mild traumatic brain injury?

Vivian A. Guedes et al.

NEUROLOGY (2020)

Add to Collection

Review Neurosciences

Microbiome in Multiple Sclerosis: Where Are We, What We Know and Do Not Know

Marina Kleopatra Boziki et al.

BRAIN SCIENCES (2020)

Add to Collection

Review Pharmacology & Pharmacy

A comprehensive review of non-coding RNAs functions in multiple sclerosis

Soudeh Ghafouri-Fard et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Add to Collection

Article Clinical Neurology

Contribution of Relapse-Independent Progression vs Relapse-Associated Worsening to Overall Confirmed Disability Accumulation in Typical Relapsing Multiple Sclerosis in a Pooled Analysis of 2 Randomized Clinical Trials

Ludwig Kappos et al.

JAMA NEUROLOGY (2020)

Add to Collection

Article Behavioral Sciences

Vitamin D supplementation and serum neurofilament light chain in interferon-beta-1b-treated MS patients

Katariina Hanninen et al.

BRAIN AND BEHAVIOR (2020)

Add to Collection

Article Clinical Neurology

A Score Based on NfL and Glial Markers May Differentiate Between Relapsing-Remitting and Progressive MS Course

Andre Huss et al.

FRONTIERS IN NEUROLOGY (2020)

Add to Collection

Article Clinical Neurology

CSF chitinase 3-like-1 association with disability of primary progressive MS

Francisco Perez-Miralles et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Long Noncoding RNAs and Circular RNAs in Autoimmune Diseases

Valeria Lodde et al.

BIOMOLECULES (2020)

Add to Collection

Article Clinical Neurology

NfL as a biomarker for neurodegeneration and survival in Parkinson disease

David Backstrom et al.

NEUROLOGY (2020)

Add to Collection

Article Medicine, General & Internal

Ofatumumab versus Teriflunomide in Multiple Sclerosis

Stephen L. Hauser et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

RNA-Seq profiling of leukocytes reveals a sex-dependent global circular RNA upregulation in multiple sclerosis and 6 candidate biomarkers

Leire Iparraguirre et al.

HUMAN MOLECULAR GENETICS (2020)

Add to Collection

Article Multidisciplinary Sciences

Serum neurofilament light chain predicts long term clinical outcomes in multiple sclerosis

Simon Thebault et al.

SCIENTIFIC REPORTS (2020)

Add to Collection

Article Multidisciplinary Sciences

Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity

Xavier Ayrignac et al.

SCIENTIFIC REPORTS (2020)

Add to Collection

Article Clinical Neurology

Serum neurofilament-light concentration and real-world outcome in MS

Valerie Anderson et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2020)

Add to Collection

Article Clinical Neurology

Ratio and index of Neurofilament light chain indicate its origin in Guillain-Barre Syndrome

Peter Koertvelyessy et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)

Add to Collection

Article Clinical Neurology

Levels of brain-derived neurotrophic factor in patients with multiple sclerosis

Yvonne Naegelin et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)

Add to Collection

Article Clinical Neurology

CSF neurofilament light chain testing as an aid to determine treatment strategies in MS

Saul Reyes et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Longitudinal Serum Neurofilament Levels of Multiple Sclerosis Patients Before and After Treatment with First-Line Immunomodulatory Therapies

Andre Huss et al.

BIOMEDICINES (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Competing Endogenous RNA Networks as Biomarkers in Neurodegenerative Diseases

Leticia Moreno-Garcia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Article Multidisciplinary Sciences

Renal function is associated with blood neurofilament light chain level in older adults

Shoshin Akamine et al.

SCIENTIFIC REPORTS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Whole-Transcriptome Analysis in Peripheral Blood Mononuclear Cells from Patients with Lipid-Specific Oligoclonal IgM Band Characterization Reveals Two Circular RNAs and Two Linear RNAs as Biomarkers of Highly Active Disease

Leire Iparraguirre et al.

BIOMEDICINES (2020)

Add to Collection

Article Clinical Neurology

Intrathecally produced CXCL13: A predictive biomarker in multiple sclerosis

Krista D. DiSano et al.

MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL (2020)

Add to Collection

Article Clinical Neurology

The weak association between neurofilament levels at multiple sclerosis onset and cognitive performance after 9 years

Lucie Friedova et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2020)

Add to Collection

Article Clinical Neurology

NFL and CXCL13 may reveal disease activity in clinically and radiologically stable MS

L. Novakova et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Chitinase-3 like-protein-1 function and its role in diseases

Ting Zhao et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection

Article Clinical Neurology

High neurofilament levels are associated with clinically definite multiple sclerosis in children and adults with clinically isolated syndrome

Roos M. van der Vuurst de Vries et al.

MULTIPLE SCLEROSIS JOURNAL (2019)

Add to Collection

Article Clinical Neurology

CSF inflammatory biomarkers responsive to treatment in progressive multiple sclerosis capture residual inflammation associated with axonal damage

Jeppe Romme Christensen et al.

MULTIPLE SCLEROSIS JOURNAL (2019)

Add to Collection

Article Clinical Neurology

High neurofilament levels are associated with clinically definite multiple sclerosis in children and adults with clinically isolated syndrome

Roos M. van der Vuurst de Vries et al.

MULTIPLE SCLEROSIS JOURNAL (2019)

Add to Collection

Article Clinical Neurology

CSF inflammatory biomarkers responsive to treatment in progressive multiple sclerosis capture residual inflammation associated with axonal damage

Jeppe Romme Christensen et al.

MULTIPLE SCLEROSIS JOURNAL (2019)

Add to Collection

Article Clinical Neurology

Prognostic value of cerebrospinal fluid neurofilament light chain and chitinase-3-like-1 in newly diagnosed patients with multiple sclerosis

Finn Sellebjerg et al.

MULTIPLE SCLEROSIS JOURNAL (2019)

Add to Collection

Article Clinical Neurology

Serum neurofilaments increase at progressive multifocal leukoencephalopathy onset in natalizumab-treated multiple sclerosis patients

Gloria Dalla Costa et al.

ANNALS OF NEUROLOGY (2019)

Add to Collection

Article Immunology

MALAT1 Genomic Variants and Risk of Multiple Sclerosis

Mohammad Mahdi Eftekharian et al.

IMMUNOLOGICAL INVESTIGATIONS (2019)

Add to Collection

Article Immunology

Malat1 long noncoding RNA regulates inflammation and leukocyte differentiation in experimental autoimmune encephalomyelitis

Farimah Masoumi et al.

JOURNAL OF NEUROIMMUNOLOGY (2019)

Add to Collection

Article Immunology

Cerebrospinal fluid biomarkers for predicting development of multiple sclerosis in acute optic neuritis: a population-based prospective cohort study

M. N. Olesen et al.

JOURNAL OF NEUROINFLAMMATION (2019)

Add to Collection

Article Clinical Neurology

Glial Activation Markers in CSF and Serum From Patients With Primary Progressive Multiple Sclerosis: Potential of Serum GFAP as Disease Severity Marker?

Ahmed Abdelhak et al.

FRONTIERS IN NEUROLOGY (2019)

Add to Collection

Article Clinical Neurology

Expression of disease-related miRNAs in white-matter lesions of progressive multiple sclerosis brains

Ajai Tripathi et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2019)

Add to Collection

Article Environmental Sciences

Osteopontin potentiates PM-induced IL-1α and IL-1β production via the ERK/JNK signaling pathway

Jian Wang et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2019)

Add to Collection

Article Immunology

Small non-coding RNAs as important players, biomarkers and therapeutic targets in multiple sclerosis: A comprehensive overview

Eliane Piket et al.

JOURNAL OF AUTOIMMUNITY (2019)

Add to Collection

Article Medicine, Research & Experimental

Does cognitive dysfunction correlate with neurofilament light polypeptide levels in the CSF of patients with multiple sclerosis?

Thaleia Kalatha et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2019)

Add to Collection

Article Clinical Neurology

Cerebrospinal fluid neurofilament light chain tracks cognitive impairment in multiple sclerosis

Lorenzo Gaetani et al.

JOURNAL OF NEUROLOGY (2019)

Add to Collection

Review Clinical Neurology

Neurofilament light chain as a biomarker in neurological disorders

Lorenzo Gaetani et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

Add to Collection

Article Clinical Neurology

Increased cerebrospinal fluid neurofilament light chain in central nervous system inflammatory demyelinating disease

Lijun Peng et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2019)

Add to Collection

Article Clinical Neurology

Clinical and MRI correlates of CSF neurofilament light chain levels in relapsing and progressive MS

Alfredo Damasceno et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2019)

Add to Collection

Article Clinical Neurology

miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS

Brooke Rhead et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2019)

Add to Collection

Article Genetics & Heredity

Early central vs. peripheral immunological and neurobiological effects of fingolimod-a longitudinal study

Tony Sehr et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2019)

Add to Collection

Review Immunology

Impact of B cells to the pathophysiology of multiple sclerosis

Borros M. Arneth

JOURNAL OF NEUROINFLAMMATION (2019)

Add to Collection

Editorial Material Clinical Neurology

Neurofilament light chain as an indicator of exacerbation prior to clinical symptoms in multiple sclerosis

Keith R. Edwards et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2019)

Add to Collection

Article Clinical Neurology

Cerebrospinal fluid neurofilament light chain predicts disease activity after the first demyelinating event suggestive of multiple sclerosis

Lorenzo Gaetani et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2019)

Add to Collection

Article Clinical Neurology

Profiling individual clinical responses by high-frequency serum neurofilament assessment in MS

Katja Akguen et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2019)

Add to Collection

Article Clinical Neurology

Serum neurofilament light chain in pediatric MS and other acquired demyelinating syndromes

Yu Yi M. Wong et al.

NEUROLOGY (2019)

Add to Collection

Article Clinical Neurology

Association Between Serum Neurofilament Light Chain Levels and Long-term Disease Course Among Patients With Multiple Sclerosis Followed up for 12 Years

Ester Canto et al.

JAMA NEUROLOGY (2019)

Add to Collection

Article Clinical Neurology

Combined Cerebrospinal Fluid Neurofilament Light Chain Protein and Chitinase-3 Like-1 Levels in Defining Disease Course and Prognosis in Multiple Sclerosis

Sara Gil-Perotin et al.

FRONTIERS IN NEUROLOGY (2019)

Add to Collection

Article Clinical Neurology

High serum neurofilament light chain normalizes after hematopoietic stem cell transplantation for MS

Simon Thebault et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2019)

Add to Collection

Article Genetics & Heredity

High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome

Liviu-Ionut Moldovan et al.

BMC MEDICAL GENOMICS (2019)

Add to Collection

Article Immunology

Cytokine and immune cell profiling in the cerebrospinal fluid of patients with neuro-inflammatory diseases

Gildas Lepennetier et al.

JOURNAL OF NEUROINFLAMMATION (2019)

Add to Collection

Article Immunology

Analysis of miRNA signatures in CSF identifies upregulation of miR-21 and miR-146a/b in patients with multiple sclerosis and active lesions

Maria Munoz-San Martin et al.

JOURNAL OF NEUROINFLAMMATION (2019)

Add to Collection

Article Clinical Neurology

Dimethyl fumarate decreases neurofilament light chain in CSF and blood of treatment naive relapsing MS patients

Tobias Sejbaek et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

Add to Collection

Review Immunology

Resolution of inflammation during multiple sclerosis

F. Ruiz et al.

SEMINARS IN IMMUNOPATHOLOGY (2019)

Add to Collection

Article Clinical Neurology

Vitamin D supplementation and neurofilament light chain in multiple sclerosis

Trygve Holmoy et al.

ACTA NEUROLOGICA SCANDINAVICA (2019)

Add to Collection

Article Behavioral Sciences

Contributing factors to health-related quality of life in multiple sclerosis

Tamas Biernacki et al.

BRAIN AND BEHAVIOR (2019)

Add to Collection

Article Clinical Neurology

The predictive value of CSF multiple assay in multiple sclerosis: A single center experience

C. De Fino et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2019)

Add to Collection

Article Clinical Neurology

Leptin rs7799039 polymorphism is associated with multiple sclerosis risk in Kuwait

Mohammed Dashti et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2019)

Add to Collection

Article Clinical Neurology

Fatigue scores correlate with other self-assessment data, but not with clinical and biomarker parameters, in CIS and RRMS

Irene Hakansson et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2019)

Add to Collection

Article Clinical Neurology

A Pilot Cross-Sectional Study to Investigate the Biomarker Potential of Phosphorylated Neurofilament-H and Immune Mediators of Disability in Patients With 5 Year Relapsing-Remitting Multiple Sclerosis

Maria Ines Herrera et al.

FRONTIERS IN NEUROLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

LncRNAs, MALAT1 and lnc-DC as potential biomarkers for multiple sclerosis diagnosis

Olfat G. Shaker et al.

BIOSCIENCE REPORTS (2019)

Add to Collection

Review Clinical Neurology

Multiple sclerosis - a review

R. Dobson et al.

EUROPEAN JOURNAL OF NEUROLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Not only cancer: the long non-coding RNA MALAT1 affects the repertoire of alternatively spliced transcripts and circular RNAs in multiple sclerosis

Giulia Cardamone et al.

HUMAN MOLECULAR GENETICS (2019)

Add to Collection

Article Clinical Neurology

Prognostic value of serum neurofilaments in patients with clinically isolated syndromes

Gloria Dalla Costa et al.

NEUROLOGY (2019)

Add to Collection

Article Clinical Neurology

The Contribution of Various MRI Parameters to Clinical and Cognitive Disability in Multiple Sclerosis

Eszter Toth et al.

FRONTIERS IN NEUROLOGY (2019)

Add to Collection

Article Clinical Neurology

Comparison of plasma and cerebrospinal fluid neurofilament light in a multiple sclerosis trial

Pierre de Flon et al.

ACTA NEUROLOGICA SCANDINAVICA (2019)

Add to Collection

Article Clinical Neurology

MRI phenotypes in MS Longitudinal changes and miRNA signatures

Christopher C. Hemond et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2019)

Add to Collection

Editorial Material Clinical Neurology

No Evidence of Disease Activity (NEDA) in Multiple Sclerosis - Shifting the Goal Posts

Lekha Pandit

ANNALS OF INDIAN ACADEMY OF NEUROLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Combined microRNA and mRNA expression analysis in pediatric multiple sclerosis: an integrated approach to uncover novel pathogenic mechanisms of the disease

Maria Liguori et al.

HUMAN MOLECULAR GENETICS (2018)

Add to Collection

Article Clinical Neurology

Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod

Fredrik Piehl et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

Add to Collection

Article Clinical Neurology

Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod

Fredrik Piehl et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

Add to Collection

Article Clinical Neurology

Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

Nazira J. Albargothy et al.

ACTA NEUROPATHOLOGICA (2018)

Add to Collection

Review Medicine, Research & Experimental

Dysregulated Network of miRNAs Involved in the Pathogenesis of Multiple Sclerosis

Sanam Dolati et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Add to Collection

Article Clinical Neurology

Neurofilament light chain and oligoclonal bands are prognostic biomarkers in radiologically isolated syndrome

Clara Matute-Blanch et al.

BRAIN (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Metazoan MicroRNAs

David P. Bartel

CELL (2018)

Add to Collection

Review Clinical Neurology

Insights into the Mechanisms That May Clarify Obesity as a Risk Factor for Multiple Sclerosis

Marije J. D. Huitema et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2018)

Add to Collection

Article Clinical Neurology

Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain

E. Quintana et al.

EUROPEAN JOURNAL OF NEUROLOGY (2018)

Add to Collection

Article Clinical Neurology

ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis

X. Montalban et al.

EUROPEAN JOURNAL OF NEUROLOGY (2018)

Add to Collection

Article Immunology

Immune-related miRNA expression patterns in peripheral blood mononuclear cells differ in multiple sclerosis relapse and remission

Natalia Baulina et al.

JOURNAL OF NEUROIMMUNOLOGY (2018)

Add to Collection

Article Immunology

Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis

Irene Hakansson et al.

JOURNAL OF NEUROINFLAMMATION (2018)

Add to Collection

Article Clinical Neurology

Serum and cerebrospinal neurofilament light chain levels in patients with acquired peripheral neuropathies

Sara Mariotto et al.

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM (2018)

Add to Collection

Article Clinical Neurology

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

Alan J. Thompson et al.

LANCET NEUROLOGY (2018)

Add to Collection

Review Clinical Neurology

Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Melanie D. Sweeney et al.

NATURE REVIEWS NEUROLOGY (2018)

Add to Collection

Review Multidisciplinary Sciences

Osteopontin (OPN) as a CSF and blood biomarker for multiple sclerosis: A systematic review and meta-analysis

Elmira Agah et al.

PLOS ONE (2018)

Add to Collection

Review Medicine, General & Internal

Association between circulating leptin levels and multiple sclerosis: a systematic review and meta-analysis

Xue-Feng Xie et al.

POSTGRADUATE MEDICAL JOURNAL (2018)

Add to Collection

Article Medicine, Research & Experimental

Multiple Sclerosis Pathology

Hans Lassmann

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)

Add to Collection

Article Clinical Neurology

Disease activity in progressive multiple sclerosis can be effectively reduced by cladribine

O. Yildiz et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2018)

Add to Collection

Review Oncology

Circular RNAs in Cancer - Lessons Learned From microRNAs

Mihnea Dragomir et al.

FRONTIERS IN ONCOLOGY (2018)

Add to Collection

Article Cardiac & Cardiovascular Systems

P2908Serum light-chain neurofilament, a brain lesion marker, correlates with CHA2DS2-VASc score among patients with atrial fibrillation: a cross-sectional study

S Aeschbacher et al.

EUROPEAN HEART JOURNAL (2018)

Add to Collection

Article Clinical Neurology

Neurofilaments and 10-year follow-up in multiple sclerosis

Alok Bhan et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

Add to Collection

Review Clinical Neurology

Neurofilaments as biomarkers in neurological disorders

Michael Khalil et al.

NATURE REVIEWS NEUROLOGY (2018)

Add to Collection

Article Multidisciplinary Sciences

BDNF rs6265 polymorphism methylation in Multiple Sclerosis: A possible marker of disease progression

Viviana Nociti et al.

PLOS ONE (2018)

Add to Collection

Article Multidisciplinary Sciences

Serum GFAP as a biomarker for disease severity in multiple sclerosis

A. Abdelhak et al.

SCIENTIFIC REPORTS (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Investigating the Role of MicroRNA and Transcription Factor Co-regulatory Networks in Multiple Sclerosis Pathogenesis

Nicoletta Nuzziello et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Add to Collection

Article Clinical Neurology

Poster Session 3

Multiple Sclerosis Journal (2018)

Add to Collection

Article Clinical Neurology

Oral presentations

Multiple Sclerosis Journal (2018)

Add to Collection

Article Cell & Tissue Engineering

SOX4 inhibits oligodendrocyte differentiation of embryonic neural stem cells in vitro by inducing Hes5 expression

Luca Braccioli et al.

STEM CELL RESEARCH (2018)

Add to Collection

Review Immunology

Circular RNAs and Their Emerging Roles in Immune Regulation

Lan Yang et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Article Clinical Neurology

CSF-Progranulin and Neurofilament Light Chain Levels in Patients With Radiologically Isolated Syndrome-Sign of Inflammation

Marc Pawlitzki et al.

FRONTIERS IN NEUROLOGY (2018)

Add to Collection

Article Clinical Neurology

Neurofilament light chain serum levels correlate with 10-year MRI outcomes in multiple sclerosis

Tanuja Chitnis et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2018)

Add to Collection

Article Genetics & Heredity

Interpreting Non-coding Genetic Variation in Multiple Sclerosis Genome-Wide Associated Regions

Elvezia Maria Paraboschi et al.

FRONTIERS IN GENETICS (2018)

Add to Collection

Review Biochemistry & Molecular Biology

The novel roles of circular RNAs in metabolic organs

Zhi-Chun Zhang et al.

GENES & DISEASES (2018)

Add to Collection

Article Clinical Neurology

Identification of MS-specific serum miRNAs in an international multicenter study

Keren Regev et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2018)

Add to Collection

Review Immunology

Circulating immune cells in multiple sclerosis

A. P. Jones et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2017)

Add to Collection

Article Clinical Neurology

Cerebrospinal fluid levels of neurofilament and tau correlate with brain atrophy in natalizumab-treated multiple sclerosis

J. Mellergard et al.

EUROPEAN JOURNAL OF NEUROLOGY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Cerebrospinal fluid biomarkers as a measure of disease activity and treatment efficacy in relapsing-remitting multiple sclerosis

Lenka Novakova et al.

JOURNAL OF NEUROCHEMISTRY (2017)

Add to Collection

Article Clinical Neurology

Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis

Lenka Novakova et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

Add to Collection

Article Clinical Neurology

Circulating microRNAs as biomarkers in progressive multiple sclerosis

Julia Vistbakka et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

Add to Collection

Review Neurosciences

Epigenetic Modifications and Therapy in Multiple Sclerosis

Saeed Aslani et al.

NEUROMOLECULAR MEDICINE (2017)

Add to Collection

Article Clinical Neurology

Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis

Lenka Novakova et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

Add to Collection

Article Clinical Neurology

Circulating microRNAs as biomarkers in progressive multiple sclerosis

Julia Vistbakka et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis

Leire Iparraguirre et al.

HUMAN MOLECULAR GENETICS (2017)

Add to Collection

Article Medicine, Research & Experimental

Microarray analysis of circular RNA expression patterns in polarized macrophages

Yingying Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

Add to Collection

Article Biochemistry & Molecular Biology

The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis

Giulia Cardamone et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Add to Collection

Article Immunology

Early cognitive impairment along with decreased stress-induced BDNF in male and female patients with newly diagnosed multiple sclerosis

Barbora Prokopova et al.

JOURNAL OF NEUROIMMUNOLOGY (2017)

Add to Collection

Article Immunology

Chitinase 3-like 1 is associated with the response to interferon-beta treatment in multiple sclerosis

Clara Matute-Blanch et al.

JOURNAL OF NEUROIMMUNOLOGY (2017)

Add to Collection

Article Immunology

BAFF Index and CXCL13 levels in the cerebrospinal fluid associate respectively with intrathecal IgG synthesis and cortical atrophy in multiple sclerosis at clinical onset

M. Puthenparampil et al.

JOURNAL OF NEUROINFLAMMATION (2017)

Add to Collection

Article Clinical Neurology

High risk of early conversion to multiple sclerosis in clinically isolated syndromes with dissemination in space at baseline

Lorenzo Gaetani et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2017)

Add to Collection

Article Clinical Neurology

CXCL10 and CXCL13 chemokines in patients with relapsing remitting and primary progressive multiple sclerosis

Piotr Iwanowski et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2017)

Add to Collection

Editorial Material Biochemistry & Molecular Biology

Antiviral Immunity and Circular RNA: No End in Sight

Cristhian Cadena et al.

MOLECULAR CELL (2017)

Add to Collection

Article Clinical Neurology

Defining active progressive multiple sclerosis

Finn Sellebjerg et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

Add to Collection

Article Clinical Neurology

miRNAs in cerebrospinal fluid identify patients with MS and specifically those with lipid-specific oligoclonal IgM bands

Ester Quintana et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

Add to Collection

Article Clinical Neurology

Serum neurofilament is associated with progression of brain atrophy and disability in early MS

Jens Kuhle et al.

NEUROLOGY (2017)

Add to Collection

Article Clinical Neurology

Monitoring disease activity in multiple sclerosis using serum neurofilament light protein

Lenka Novakova et al.

NEUROLOGY (2017)

Add to Collection

Article Clinical Neurology

Blood-based NfL A biomarker for differential diagnosis of parkinsonian disorder

Oskar Hansson et al.

NEUROLOGY (2017)

Add to Collection

Article Neurosciences

OSTEOPONTIN-METALLOTHIONEIN I/II INTERACTIONS IN EXPERIMENTAL AUTOIMMUNUNE ENCEPHALOMYELITIS

Hrvoje Jakovac et al.

NEUROSCIENCE (2017)

Add to Collection

Review Clinical Neurology

Ocrelizumab and Other CD20+ B-Cell-Depleting Therapies in Multiple Sclerosis

Jeffrey M. Gelfand et al.

NEUROTHERAPEUTICS (2017)

Add to Collection

Article Cell Biology

Neurofilaments and Neurofilament Proteins in Health and Disease

Aidong Yuan et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

Add to Collection

Article Clinical Neurology

Association Between Serum MicroRNAs and Magnetic Resonance Imaging Measures of Multiple Sclerosis Severityle

Keren Regev et al.

JAMA NEUROLOGY (2017)

Add to Collection

Article Clinical Neurology

Defining active progressive multiple sclerosis

Finn Sellebjerg et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

Add to Collection

Article Clinical Neurology

miRNAs in cerebrospinal fluid identify patients with MS and specifically those with lipid-specific oligoclonal IgM bands

Ester Quintana et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

Add to Collection

Article Clinical Neurology

Prevalence of of cognitive impairment among Hungarian patients with relapsing-remitting multiple sclerosis and clinically isolated syndrome

Sandi Daniel et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2017)

Add to Collection

Article Clinical Neurology

Pharmacodynamic effects of daclizumab in the intrathecal compartment

Mika Komori et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2017)

Add to Collection

Article Clinical Neurology

Serum Neurofilament Light: A Biomarker of Neuronal Damage in Multiple Sclerosis

Giulio Disanto et al.

ANNALS OF NEUROLOGY (2017)

Add to Collection

Article Clinical Neurology

Global Exosome Transcriptome Profiling Reveals Biomarkers for Multiple Sclerosis

Igor Selmaj et al.

ANNALS OF NEUROLOGY (2017)

Add to Collection

Article Cell Biology

miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS

Haibo Wang et al.

DEVELOPMENTAL CELL (2017)

Add to Collection

Review Clinical Neurology

Optimizing treatment success in multiple sclerosis

Tjalf Ziemssen et al.

JOURNAL OF NEUROLOGY (2016)

Add to Collection

Article Clinical Neurology

Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome

Giulio Disanto et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2016)

Add to Collection

Article Clinical Neurology

Vitamin D and axonal injury in multiple sclerosis

L. Sandberg et al.

MULTIPLE SCLEROSIS JOURNAL (2016)

Add to Collection

Article Clinical Neurology

Vitamin D and axonal injury in multiple sclerosis

L. Sandberg et al.

MULTIPLE SCLEROSIS JOURNAL (2016)

Add to Collection

Review Biochemistry & Molecular Biology

Are circulating microRNAs peripheral biomarkers for Alzheimer's disease?

Subodh Kumar et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)

Add to Collection

Article Medical Laboratory Technology

Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa

Jens Kuhle et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2016)

Add to Collection

Article Clinical Neurology

Cerebrospinal fluid chitinase-3-like 2 and chitotriosidase are potential prognostic biomarkers in early multiple sclerosis

M. Mollgaard et al.

EUROPEAN JOURNAL OF NEUROLOGY (2016)

Add to Collection

Article Immunology

YKL-40 is a CSF biomarker of intrathecal inflammation in secondary progressive multiple sclerosis

Joachim Burman et al.

JOURNAL OF NEUROIMMUNOLOGY (2016)

Add to Collection

Article Immunology

Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis

M. Alba Mane-Martinez et al.

JOURNAL OF NEUROIMMUNOLOGY (2016)

Add to Collection

Article Clinical Neurology

Reduced inflammation in relapsing-remitting multiple sclerosis after therapy switch to rituximab

Pierre de Flon et al.

NEUROLOGY (2016)

Add to Collection

Article Multidisciplinary Sciences

Analyzing the Release of Copeptin from the Heart in Acute Myocardial Infarction Using a Transcoronary Gradient Model

Jes-Niels Boeckel et al.

SCIENTIFIC REPORTS (2016)

Add to Collection

Article Multidisciplinary Sciences

SncRNA (microRNA & snoRNA) opposite expression pattern found in multiple sclerosis relapse and remission is sex dependent

Maider Munoz-Culla et al.

SCIENTIFIC REPORTS (2016)

Add to Collection

Article Immunology

Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo

Elena Boggio et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2016)

Add to Collection

Review Clinical Neurology

Interleukin 7 receptor polymorphisms and the risk of multiple sclerosis: A meta-analysis

Soheil Tavakolpour

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2016)

Add to Collection

Review Biochemistry & Molecular Biology

MicroRNAs: The Role in Autoimmune Inflammation

N. M. Baulina et al.

ACTA NATURAE (2016)

Add to Collection

Review Genetics & Heredity

A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome

Bastian Fromm et al.

ANNUAL REVIEW OF GENETICS, VOL 49 (2015)

Add to Collection

Review Biochemistry & Molecular Biology

Cerebrospinal fluid proteomics in multiple sclerosis

Ann C. Kroksveen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2015)

Add to Collection

Article Clinical Neurology

Defining reliable disability outcomes in multiple sclerosis

Tomas Kalincik et al.

BRAIN (2015)

Add to Collection

Article Clinical Neurology

Chitinase 3-like 1: prognostic biomarker in clinically isolated syndromes

Ester Canto et al.

BRAIN (2015)

Add to Collection

Review Dentistry, Oral Surgery & Medicine

Osteopontin in Immune-mediated Diseases

S. R. Rittling et al.

JOURNAL OF DENTAL RESEARCH (2015)

Add to Collection

Article Immunology

Association of copeptin and cortisol in newly diagnosed multiple sclerosis patients

Agnieszka Baranowska-Bik et al.

JOURNAL OF NEUROIMMUNOLOGY (2015)

Add to Collection

Article Immunology

Cerebrospinal fluid CXCL13 in clinically isolated syndrome patients: Association with oligoclonal IgM bands and prediction of Multiple Sclerosis diagnosis

Diana Ferraro et al.

JOURNAL OF NEUROIMMUNOLOGY (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

Agnieszka Rybak-Wolf et al.

MOLECULAR CELL (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Functions of neurofilaments in synapses

A Yuan et al.

MOLECULAR PSYCHIATRY (2015)

Add to Collection

Article Clinical Neurology

Cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain predict multiple sclerosis development and disability after optic neuritis

S. Modvig et al.

MULTIPLE SCLEROSIS JOURNAL (2015)

Add to Collection

Review Clinical Neurology

miRNA in multiple sclerosis: search for novel biomarkers

Roopali Gandhi

MULTIPLE SCLEROSIS JOURNAL (2015)

Add to Collection

Article Clinical Neurology

Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study

J. Kuhle et al.

MULTIPLE SCLEROSIS JOURNAL (2015)

Add to Collection

Article Clinical Neurology

Glial and neuronal markers in cerebrospinal fluid predict progression in multiple sclerosis

M. Alba Mane Martinez et al.

MULTIPLE SCLEROSIS JOURNAL (2015)

Add to Collection

Article Clinical Neurology

Fingolimod and CSF neurofilament light chain levels in relapsing-remitting multiple sclerosis

Jens Kuhle et al.

NEUROLOGY (2015)

Add to Collection

Article Clinical Neurology

Cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain predict multiple sclerosis development and disability after optic neuritis

S. Modvig et al.

MULTIPLE SCLEROSIS JOURNAL (2015)

Add to Collection

Review Clinical Neurology

miRNA in multiple sclerosis: search for novel biomarkers

Roopali Gandhi

MULTIPLE SCLEROSIS JOURNAL (2015)

Add to Collection

Article Clinical Neurology

Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study

J. Kuhle et al.

MULTIPLE SCLEROSIS JOURNAL (2015)

Add to Collection

Article Clinical Neurology

Glial and neuronal markers in cerebrospinal fluid predict progression in multiple sclerosis

M. Alba Mane Martinez et al.

MULTIPLE SCLEROSIS JOURNAL (2015)

Add to Collection

Review Clinical Neurology

Is it time to target no evident disease activity (NEDA) in multiple sclerosis?

Gavin Giovannoni et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2015)

Add to Collection

Article Clinical Neurology

Clinically Isolated Syndromes: Clinical Characteristics, Differential Diagnosis, and Management

Huesnue Efendi

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Selected Extracellular microRNA as Potential Biomarkers of Multiple Sclerosis Activity-Preliminary Study

Magdalena Justyna Kacperska et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2015)

Add to Collection

Review Neurosciences

Epigenetics of Multiple Sclerosis: An Updated Review

Cem Ismail Kucukali et al.

NEUROMOLECULAR MEDICINE (2015)

Add to Collection

Article Multidisciplinary Sciences

Correlation of circular RNA abundance with proliferation - exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues

Anna Bachmayr-Heyda et al.

SCIENTIFIC REPORTS (2015)

Add to Collection

Review Immunology

The emerging role of circulating microRNAs as biomarkers in autoimmune diseases

Li Zeng et al.

AUTOIMMUNITY (2014)

Add to Collection

Article Immunology

The improvement of cognitive functions is associated with a decrease of plasma Osteopontin levels in Natalizumab treated relapsing multiple sclerosis

Pietro Iaffaldano et al.

BRAIN BEHAVIOR AND IMMUNITY (2014)

Add to Collection

Review Pharmacology & Pharmacy

Osteopontin as a therapeutic target for cancer

Monalisa Bandopadhyay et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2014)

Add to Collection

Article Immunology

Increased Circulating Th17 Cell Populations and Elevated CSF Osteopontin and IL-17 Concentrations in Patients with Guillain-Barr, Syndrome

Rong kun Han et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2014)

Add to Collection

Review Endocrinology & Metabolism

Novel Aspects of Glucocorticoid Actions

E. T. Uchoa et al.

JOURNAL OF NEUROENDOCRINOLOGY (2014)

Add to Collection

Article Immunology

CSF levels of YKL-40 are increased in MS and replaces with immunosuppressive treatment

Clas Malmestrom et al.

JOURNAL OF NEUROIMMUNOLOGY (2014)

Add to Collection

Article Clinical Neurology

Evaluation of circulating osteopontin levels in an unselected cohort of patients with multiple sclerosis: relevance for biomarker development

Pia Kivisaekk et al.

MULTIPLE SCLEROSIS JOURNAL (2014)

Add to Collection

Article Clinical Neurology

Immunosuppressive therapy reduces axonal damage in progressive multiple sclerosis

Markus Axelsson et al.

MULTIPLE SCLEROSIS JOURNAL (2014)

Add to Collection

Letter Clinical Neurology

No evidence for an association of osteopontin plasma levels with disease activity in multiple sclerosis

Tessel F. Runia et al.

MULTIPLE SCLEROSIS JOURNAL (2014)

Add to Collection

Article Clinical Neurology

Neurofilament light antibodies in serum reflect response to natalizumab treatment in multiple sclerosis

Sandra Amor et al.

MULTIPLE SCLEROSIS JOURNAL (2014)

Add to Collection

Review Multidisciplinary Sciences

The multilayered complexity of ceRNA crosstalk and competition

Yvonne Tay et al.

NATURE (2014)

Add to Collection

Review Biotechnology & Applied Microbiology

Detecting and characterizing circular RNAs

William R. Jeck et al.

NATURE BIOTECHNOLOGY (2014)

Add to Collection

Review Clinical Neurology

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis

Manuel A. Friese et al.

NATURE REVIEWS NEUROLOGY (2014)

Add to Collection

Article Genetics & Heredity

Genetic variants in IL2RA and IL7R affect multiple sclerosis disease risk and progression

Anthony L. Traboulsee et al.

NEUROGENETICS (2014)

Add to Collection

Article Clinical Neurology

Natalizumab in progressive MS Results of an open-label, phase 2A, proof-of-concept trial

Jeppe Romme Christensen et al.

NEUROLOGY (2014)

Add to Collection

Editorial Material Clinical Neurology

Neurofilament light and heavy subunits compared as therapeutic biomarkers in multiple sclerosis

J. Kuhle et al.

ACTA NEUROLOGICA SCANDINAVICA (2013)

Add to Collection

Article Clinical Neurology

Circulating MicroRNAs as biomarkers for disease staging in multiple sclerosis

Roopali Gandhi et al.

ANNALS OF NEUROLOGY (2013)

Add to Collection

Article Clinical Neurology

Increased leptin and A-FABP levels in relapsing and progressive forms of MS

Silvia Messina et al.

BMC NEUROLOGY (2013)

Add to Collection

Review Oncology

Circular RNA and miR-7 in Cancer

Thomas B. Hansen et al.

CANCER RESEARCH (2013)

Add to Collection

Article Biochemistry & Molecular Biology

Expression and Genetic Analysis of MicroRNAs Involved in Multiple Sclerosis

Elisa Ridolfi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Add to Collection

Article Immunology

The influence of disease duration, clinical course, and immunosuppressive therapy on the synthesis of intrathecal oligoclonal IgG bands in multiple sclerosis

Markus Axelsson et al.

JOURNAL OF NEUROIMMUNOLOGY (2013)

Add to Collection

Article Clinical Neurology

Evaluating biomarkers of neuronal degeneration and neuroinflammation in CSF of patients with multiple sclerosis-osteopontin as a potential marker of clinical severity

Levente Szalardy et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2013)

Add to Collection

Review Clinical Neurology

Pathology and disease mechanisms in different stages of multiple sclerosis

Hans Lassmann

JOURNAL OF THE NEUROLOGICAL SCIENCES (2013)

Add to Collection

Article Biochemistry & Molecular Biology

Circular Intronic Long Noncoding RNAs

Yang Zhang et al.

MOLECULAR CELL (2013)

Add to Collection

Article Clinical Neurology

Multiple sclerosis risk genotypes correlate with an elevated cerebrospinal fluid level of the suggested prognostic marker CXCL13

M. Linden et al.

MULTIPLE SCLEROSIS JOURNAL (2013)

Add to Collection

Article Clinical Neurology

CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis

Jeppe Romme Christensen et al.

MULTIPLE SCLEROSIS JOURNAL (2013)

Add to Collection

Article Clinical Neurology

CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome

M. Khalil et al.

MULTIPLE SCLEROSIS JOURNAL (2013)

Add to Collection

Article Clinical Neurology

Differential microRNA expression in blood in multiple sclerosis

Helle Bach Sondergaard et al.

MULTIPLE SCLEROSIS JOURNAL (2013)

Add to Collection

Article Clinical Neurology

CXCL13 is a biomarker of inflammation in multiple sclerosis, neuromyelitis optica, and other neurological conditions

Enrique Alvarez et al.

MULTIPLE SCLEROSIS JOURNAL (2013)

Add to Collection

Article Multidisciplinary Sciences

Natural RNA circles function as efficient microRNA sponges

Thomas B. Hansen et al.

NATURE (2013)

Add to Collection

Article Endocrinology & Metabolism

Severe Disability in Patients with Relapsing-Remitting Multiple Sclerosis Is Associated with Profound Changes in the Regulation of Leptin Secretion

Mario Rotondi et al.

NEUROIMMUNOMODULATION (2013)

Add to Collection

Article Multidisciplinary Sciences

Cortisol Awakening Response Is Linked to Disease Course and Progression in Multiple Sclerosis

Simone Kern et al.

PLOS ONE (2013)

Add to Collection

Article Multidisciplinary Sciences

The BDNF Val66Met Polymorphism Has Opposite Effects on Memory Circuits of Multiple Sclerosis Patients and Controls

Francesco Fera et al.

PLOS ONE (2013)

Add to Collection

Article Multidisciplinary Sciences

Correction: Adipocytokine Profile, Cytokine Levels and Foxp3 Expression in Multiple Sclerosis: a Possible Link to Susceptibility and Clinical Course of Disease

Solaleh Emamgholipour et al.

PLoS One (2013)

Add to Collection

Review Pharmacology & Pharmacy

GDNF, NGF and BDNF as therapeutic options for neurodegeneration

Shelley J. Allen et al.

PHARMACOLOGY & THERAPEUTICS (2013)

Add to Collection

Article Genetics & Heredity

Trash or Treasure: extracellular microRNAs and cell-to-cell communication

Nobuyoshi Kosaka et al.

Frontiers in Genetics (2013)

Add to Collection

Review Clinical Neurology

Updates on Clinically Isolated Syndrome and Diagnostic Criteria for Multiple Sclerosis

Jacqueline F. Marcus et al.

NEUROHOSPITALIST (2013)

Add to Collection

Review Medicine, General & Internal

Immunomodulators and immunosuppressants for multiple sclerosis: a network meta-analysis

Graziella Filippini et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2013)

Add to Collection

Review Medical Laboratory Technology

Copeptin and its potential role in diagnosis and prognosis of various diseases

Lidija Dobsa et al.

BIOCHEMIA MEDICA (2013)

Add to Collection

Article Hematology

Basis of CTLA-4 function in regulatory and conventional CD4+ T cells

Xuguang Tai et al.

BLOOD (2012)

Add to Collection

Article Clinical Neurology

TH1/TH2 Cytokine profile in relapsing-remitting multiple sclerosis patients treated with Glatiramer acetate or Natalizumab

Celia Oreja-Guevara et al.

BMC NEUROLOGY (2012)

Add to Collection

Article Immunology

The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression

Cristoforo Comi et al.

CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2012)

Add to Collection

Review Biochemistry & Molecular Biology

Regulating the immune system via IL-15 transpresentation

Eliseo F. Castillo et al.

CYTOKINE (2012)

Add to Collection

Article Biochemistry & Molecular Biology

Proteomic Analysis of Cerebrospinal Fluid in a Fulminant Case of Multiple Sclerosis

Judit Fuvesi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)

Add to Collection

Article Oncology

Serum YKL-40 following resection for cerebral glioblastoma

Daniela Bernardi et al.

JOURNAL OF NEURO-ONCOLOGY (2012)

Add to Collection

Article Immunology

Polymorphisms of the BDNF gene show neither association with multiple sclerosis susceptibility nor clinical course

Inger-Lise Mero et al.

JOURNAL OF NEUROIMMUNOLOGY (2012)

Add to Collection

Article Immunology

Increased levels of IL-23 and osteopontin in serum and cerebrospinal fluid of multiple sclerosis patients

Shi-Rong Wen et al.

JOURNAL OF NEUROIMMUNOLOGY (2012)

Add to Collection

Article Immunology

CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation

Markus C. Kowarik et al.

JOURNAL OF NEUROINFLAMMATION (2012)

Add to Collection

Article Neurosciences

Expansion of Neurofilament Medium C Terminus Increases Axonal Diameter Independent of Increases in Conduction Velocity or Myelin Thickness

Devin M. Barry et al.

JOURNAL OF NEUROSCIENCE (2012)

Add to Collection

Article Neurosciences

Peripherin Is a Subunit of Peripheral Nerve Neurofilaments: Implications for Differential Vulnerability of CNS and Peripheral Nervous System Axons

Aidong Yuan et al.

JOURNAL OF NEUROSCIENCE (2012)

Add to Collection

Review Clinical Neurology

Clinically isolated syndromes

David H. Miller et al.

LANCET NEUROLOGY (2012)

Add to Collection

Article Clinical Neurology

Protein biomarkers for multiple sclerosis: semi-quantitative analysis of cerebrospinal fluid candidate protein biomarkers in different forms of multiple sclerosis

Timucin Avsar et al.

MULTIPLE SCLEROSIS JOURNAL (2012)

Add to Collection

Article Clinical Neurology

Evaluation of the relationship between leptin, resistin, adiponectin and natural regulatory T cells in relapsing-remitting multiple sclerosis

Lukasz Kraszula et al.

NEUROLOGIA I NEUROCHIRURGIA POLSKA (2012)

Add to Collection

Review Clinical Neurology

Rituximab combination therapy in relapsing multiple sclerosis

Anne H. Cross et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2012)

Add to Collection

Article Clinical Neurology

Axonal Damage in Relapsing Multiple Sclerosis is Markedly Reduced by Natalizumab

Martin Gunnarsson et al.

ANNALS OF NEUROLOGY (2011)

Add to Collection

Article Clinical Neurology

Impaired neurosteroid synthesis in multiple sclerosis

Farshid Noorbakhsh et al.

BRAIN (2011)

Add to Collection

Article Clinical Neurology

Patterns of Th1/Th2 Cytokines Predict Clinical Response in Multiple Sclerosis Patients Treated with Glatiramer Acetate

Hayrettin Tumani et al.

EUROPEAN NEUROLOGY (2011)

Add to Collection

Article Neurosciences

Axonal damage in the making: Neurofilament phosphorylation, proton mobility and magnetisation transfer in multiple sclerosis normal appearing white matter

A. Petzold et al.

EXPERIMENTAL NEUROLOGY (2011)

Add to Collection

Article Biochemistry & Molecular Biology

A Complex of Nuclear Factor I-X3 and STAT3 Regulates Astrocyte and Glioma Migration through the Secreted Glycoprotein YKL-40

Sandeep K. Singh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Add to Collection

Article Biochemistry & Molecular Biology

Role of YKL-40 in the Angiogenesis, Radioresistance, and Progression of Glioblastoma

Ralph A. Francescone et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Add to Collection

Article Clinical Neurology

Glial fibrillary acidic protein: a potential biomarker for progression in multiple sclerosis

M. Axelsson et al.

JOURNAL OF NEUROLOGY (2011)

Add to Collection

Article Clinical Neurology

Osteopontin concentrations are increased in cerebrospinal fluid during attacks of multiple sclerosis

Lars Bornsen et al.

MULTIPLE SCLEROSIS JOURNAL (2011)

Add to Collection

Article Clinical Neurology

Cerebrospinal fluid CXCL13 in multiple sclerosis: a suggestive prognostic marker for the disease course

Mohsen Khademi et al.

MULTIPLE SCLEROSIS JOURNAL (2011)

Add to Collection

Article Clinical Neurology

Multiple sclerosis: BAFF and CXCL13 in cerebrospinal fluid

Samia Ragheb et al.

MULTIPLE SCLEROSIS JOURNAL (2011)

Add to Collection

Article Clinical Neurology

The emerging role of microRNAs in multiple sclerosis

Andreas Junker et al.

NATURE REVIEWS NEUROLOGY (2011)

Add to Collection

Review Neurosciences

Multivesicular bodies in neurons: Distribution, protein content, and trafficking functions

Christopher S. Von Bartheld et al.

PROGRESS IN NEUROBIOLOGY (2011)

Add to Collection

Article Genetics & Heredity

Sexually Dimorphic Effect of the Val66Met Polymorphism of BDNF on Susceptibility to Alzheimer's Disease: New Data and Meta-Analysis

Noriko Fukumoto et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2010)

Add to Collection

Article Clinical Neurology

Changes in B- and T-Lymphocyte and Chemokine Levels With Rituximab Treatment in Multiple Sclerosis

Laura Piccio et al.

ARCHIVES OF NEUROLOGY (2010)

Add to Collection

Article Clinical Neurology

The natural history of multiple sclerosis, a geographically based study 10: relapses and long-term disability

Antonio Scalfari et al.

BRAIN (2010)

Add to Collection

Article Clinical Neurology

Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple sclerosis

Manuel Comabella et al.

BRAIN (2010)

Add to Collection

Review Immunology

At the crossroad between immunity and metabolism: focus on leptin

Javier Conde et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2010)

Add to Collection

Review Biochemistry & Molecular Biology

Regulatory Effects of Interferon-beta on Osteopontin and Interleukin-17 Expression in Multiple Sclerosis

Jian Hong et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2010)

Add to Collection

Article Immunology

In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases

Dafna Bonneh-Barkay et al.

JOURNAL OF NEUROINFLAMMATION (2010)

Add to Collection

Article Biochemistry & Molecular Biology

Population genetic study of the brain-derived neurotrophic factor (BDNF) gene

T. L. Petryshen et al.

MOLECULAR PSYCHIATRY (2010)

Add to Collection

Article Clinical Neurology

Neurofilament light as a prognostic marker in multiple sclerosis

Jonatan Salzer et al.

MULTIPLE SCLEROSIS JOURNAL (2010)

Add to Collection

Article Clinical Neurology

Rituximab add-on therapy for breakthrough relapsing multiple sclerosis - A 52-week phase II trial

R. T. Naismith et al.

NEUROLOGY (2010)

Add to Collection

Article Multidisciplinary Sciences

The Chemokine CXCL13 Is a Prognostic Marker in Clinically Isolated Syndrome (CIS)

Johannes Brettschneider et al.

PLOS ONE (2010)

Add to Collection

Article Medicine, General & Internal

The stress hormone copeptin: a new prognostic biomarker in acute illness

Mira Katan et al.

SWISS MEDICAL WEEKLY (2010)

Add to Collection

Article Clinical Neurology

Copeptin: A Novel, Independent Prognostic Marker in Patients with Ischemic Stroke

Mira Katan et al.

ANNALS OF NEUROLOGY (2009)

Add to Collection

Article Oncology

YKL-40 tissue expression and plasma levels in patients with ovarian cancer

Estrid V. S. Hogdall et al.

BMC CANCER (2009)

Add to Collection

Article Clinical Neurology

MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47

Andreas Junker et al.

BRAIN (2009)

Add to Collection

Article Medicine, General & Internal

Ethnic Differences in Brain-derived Neurotrophic Factor Val66Met Polymorphism in Croatian and Korean Healthy Participants

Nela Pivac et al.

CROATIAN MEDICAL JOURNAL (2009)

Add to Collection

Article Clinical Neurology

The effects of natalizumab on inflammatory mediators in multiple sclerosis: prospects for treatment-sensitive biomarkers

M. Khademi et al.

EUROPEAN JOURNAL OF NEUROLOGY (2009)

Add to Collection

Article Biochemistry & Molecular Biology

Most mammalian mRNAs are conserved targets of microRNAs

Robin C. Friedman et al.

GENOME RESEARCH (2009)

Add to Collection

Article Immunology

MicroRNA in autoimmunity and autoimmune diseases

Kaleb M. Pauley et al.

JOURNAL OF AUTOIMMUNITY (2009)

Add to Collection

Article Cell Biology

BDNF splice variants from the second promoter cluster support cell survival of differentiated neuroblastoma upon cytotoxic stress

Baj Gabriele et al.

JOURNAL OF CELL SCIENCE (2009)

Add to Collection

Article Immunology

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

Changsheng Du et al.

NATURE IMMUNOLOGY (2009)

Add to Collection

Article Clinical Neurology

Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS

F. Sellebjerg et al.

NEUROLOGY (2009)

Add to Collection

Article Clinical Neurology

Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis

C. E. Teunissen et al.

NEUROLOGY (2009)

Add to Collection

Article Cell Biology

The role of osteopontin in inflammatory processes

Susan Amanda Lund et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2009)

Add to Collection

Article Clinical Neurology

Rituximab in relapsing-remitting multiple sclerosis: A 72-week, open-label, phase I trial

Amit Bar-Or et al.

ANNALS OF NEUROLOGY (2008)

Add to Collection

Article Clinical Neurology

Specificity and correlation with disease activity of cerebrospinal fluid osteopontin levels in patients with multiple sclerosis

Soheli A. Chowdhury et al.

ARCHIVES OF NEUROLOGY (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Leptin Signaling in Breast Cancer: An Overview

Donatella Cirillo et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2008)

Add to Collection

Article Immunology

Low and dysregulated BDNF secretion from immune cells of MS patients is related to reduced neuroprotection

David Azoulay et al.

JOURNAL OF NEUROIMMUNOLOGY (2008)

Add to Collection

Article Immunology

BDNF A196G and C270T gene polymorphisms and susceptibility to multiple sclerosis in the polish population. Gender differences

Dagmara Mirowska-Guzel et al.

JOURNAL OF NEUROIMMUNOLOGY (2008)

Add to Collection

Article Immunology

Lymphoid chemokines in chronic neuroinflammation

Francesca Aloisi et al.

JOURNAL OF NEUROIMMUNOLOGY (2008)

Add to Collection

Article Clinical Neurology

Clinical markers of therapeutic response to disease modifying drugs

Carlo Pozzilli et al.

NEUROLOGICAL SCIENCES (2008)

Add to Collection

Article Multidisciplinary Sciences

Circulating microRNAs as stable blood-based markers for cancer detection

Patrick S. Mitchell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Add to Collection

Review Endocrinology & Metabolism

Copeptin: clinical use of a new biomarker

Nils G. Morgenthaler et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor

Robert Zivadinov et al.

HUMAN MOLECULAR GENETICS (2007)

Add to Collection

Article Genetics & Heredity

Variation in interleukin 7 receptor a chain (IL7R) influences risk of multiple sclerosis

Frida Lundmark et al.

NATURE GENETICS (2007)

Add to Collection

Article Genetics & Heredity

Interleukin 7 receptor a chain (IL7R) shows allelic and functional association with multiple sclerosis

Simon G. Gregory et al.

NATURE GENETICS (2007)

Add to Collection

Article Biotechnology & Applied Microbiology

Dissecting the human BDNF locus:: Bidirectional transcription, complex splicing, and multiple promoters

Priit Pruunsild et al.

GENOMICS (2007)

Add to Collection

Article Clinical Neurology

Antibodies against light neurofilaments in multiple sclerosis patients

A. Bartos et al.

ACTA NEUROLOGICA SCANDINAVICA (2007)

Add to Collection

Article Neurosciences

Strain rate-dependent induction of reactive astrogliosis and cell death in three-dimensional neuronal-astrocytic co-cultures

D. Kacy Cullen et al.

BRAIN RESEARCH (2007)

Add to Collection

Article Clinical Neurology

Interferon-β regulates cytokines and BDNF:: greater effect in relapsing than in progressive multiple sclerosis

K. Hamomcioglu et al.

MULTIPLE SCLEROSIS JOURNAL (2007)

Add to Collection

Article Clinical Neurology

Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology

Roberta Magliozzi et al.

BRAIN (2007)

Add to Collection

Article Biochemistry & Molecular Biology

Processing of intronic microRNAs

Young-Kook Kim et al.

EMBO JOURNAL (2007)

Add to Collection

Article Behavioral Sciences

Investigating the role of brain-derived neurotrophic factor in relapsing-remitting multiple sclerosis

M. Liguori et al.

GENES BRAIN AND BEHAVIOR (2007)

Add to Collection

Article Neurosciences

α-Internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS

Aidong Yuan et al.

JOURNAL OF NEUROSCIENCE (2006)

Add to Collection

Article Genetics & Heredity

Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence

Huiping Zhang et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2006)

Add to Collection

Article Neurosciences

No association of the Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) to multiple sclerosis

Y Blanco et al.

NEUROSCIENCE LETTERS (2006)

Add to Collection

Article Clinical Neurology

Axonal damage markers in the cerebrospinal fluid of patients with clinically isolated syndrome improve predicting conversion to definite multiple sclerosis

J Brettschneider et al.

MULTIPLE SCLEROSIS JOURNAL (2006)

Add to Collection

Article Clinical Neurology

Natural history of multiple sclerosis: a unifying concept

C Confavreux et al.

BRAIN (2006)

Add to Collection

Article Clinical Neurology

Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment

M Krumbholz et al.

BRAIN (2006)

Add to Collection

Article Biochemistry & Molecular Biology

Copeptin, a stable peptide derived from the vasopressin precursor, is elevated in serum of sepsis patients

J Struck et al.

PEPTIDES (2005)

Add to Collection

Article Neurosciences

Association analysis of brain-derived neurotrophic factor (BDNF) gene 196 A/G polymorphism with Alzheimer's disease (AD) in mainland Chinese

HT Bian et al.

NEUROSCIENCE LETTERS (2005)

Add to Collection

Article Immunology

The BDNF-Val66Met polymorphism: Implications for susceptibility to multiple sclerosis and severity of disease

S Lindquist et al.

JOURNAL OF NEUROIMMUNOLOGY (2005)

Add to Collection

Article Immunology

Lower brain-derived neurotrophic factor in serum of relapsing remitting MS: Reversal by glatiramer acetate

D Azoulay et al.

JOURNAL OF NEUROIMMUNOLOGY (2005)

Add to Collection

Article Immunology

Neurotrophic factors and clinical recovery in relapsing-remitting multiple sclerosis

M Caggiula et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2005)

Add to Collection

Article Immunology

Hypothalamo-pituitary-adrenal axis activity predicts disease progression in multiple sclerosis

SM Gold et al.

JOURNAL OF NEUROIMMUNOLOGY (2005)

Add to Collection

Article Neurosciences

Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism

D Olin et al.

NEUROSCIENCE LETTERS (2005)

Add to Collection

Article Immunology

Osteopontin gene haplotypes correlate with multiple sclerosis development and progression

A Chiocchetti et al.

JOURNAL OF NEUROIMMUNOLOGY (2005)

Add to Collection

Article Clinical Neurology

Brain-derived neurotrophic factor gene polymorphisms and Alzheimer's disease

S Matsushita et al.

JOURNAL OF NEURAL TRANSMISSION (2005)

Add to Collection

Article Genetics & Heredity

Genetic variation in the brain derived neurotrophic factor gene in Alzheimer's disease

SM Bodner et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2005)

Add to Collection

Article Clinical Neurology

Genetic analysis of BDNF and TrkB gene polymorphisms in Alzheimer's disease

S Vepsäläinen et al.

JOURNAL OF NEUROLOGY (2005)

Add to Collection

Article Biochemistry & Molecular Biology

Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes

S Baskerville et al.

RNA (2005)

Add to Collection

Letter Biochemistry & Molecular Biology

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

BP Lewis et al.

CELL (2005)

Add to Collection

Review Immunology

The weight of leptin in immunity

A La Cava et al.

NATURE REVIEWS IMMUNOLOGY (2004)

Add to Collection

Article Immunology

Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis

V Viglietta et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

Add to Collection

Letter Genetics & Heredity

Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: The possibility to explain ethnic mental traits

E Shimizu et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2004)

Add to Collection

Article Clinical Neurology

Cerebrospinal fluid markers in MS patients and their healthy siblings

S Haghighi et al.

ACTA NEUROLOGICA SCANDINAVICA (2004)

Add to Collection

Article Immunology

Leptin and its soluble receptor in plasma of patients suffering from remitting-relapsing multiple sclerosis (MS) - In vitro effects of leptin on type-1 and type-2 cytokine secretion by peripheral blood mononuclear cells, T-cells and monocytes of MS patients

K Chatzantoni et al.

JOURNAL OF AUTOIMMUNITY (2004)

Add to Collection

Article Clinical Neurology

Neurofilament and glial fibrillary acidic protein in multiple sclerosis

N Norgren et al.

NEUROLOGY (2004)

Add to Collection

Article Clinical Neurology

Impaired hypothalamus-pituitary-adrenal axis activity and more severe multiple sclerosis with hypothalamic lesions

I Huitinga et al.

ANNALS OF NEUROLOGY (2004)

Add to Collection

Article Biochemistry & Molecular Biology

Identification of mammalian microRNA host genes and transcription units

A Rodriguez et al.

GENOME RESEARCH (2004)

Add to Collection

Article Clinical Neurology

Increased frequencies of serum antibodies to neurofilament light in patients with primary chronic progressive multiple sclerosis

R Ehling et al.

MULTIPLE SCLEROSIS JOURNAL (2004)

Add to Collection

Article Cell Biology

The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate

MV Rao et al.

JOURNAL OF CELL BIOLOGY (2003)

Add to Collection

Article Immunology

Leptin as a marker of multiple sclerosis activity in patients treated with interferon-beta

AP Batocchi et al.

JOURNAL OF NEUROIMMUNOLOGY (2003)

Add to Collection

Article Immunology

Brain-derived neurotrophic factor in patients with multiple sclerosis

P Sarchielli et al.

JOURNAL OF NEUROIMMUNOLOGY (2002)

Add to Collection

Article Clinical Neurology

Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations

A Petzold et al.

BRAIN (2002)

Add to Collection

Article Biochemistry & Molecular Biology

Dynamic processing of neuropeptides - Sequential conformation shaping of neurohypophysial preprohormones during intraneuronal secretory transport

R Acher et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2002)

Add to Collection

Article Clinical Neurology

Cortisol is increased in postmortem cerebrospinal fluid of multiple sclerosis patients: relationship with cytokines and sepsis

ZA Erkut et al.

MULTIPLE SCLEROSIS JOURNAL (2002)

Add to Collection

Article Clinical Neurology

BDNF and gp145trkB in multiple sclerosis brain lesions: Neuroprotective interactions between immune and neuronal cells?

C Stadelmann et al.

BRAIN (2002)

Add to Collection

Article Multidisciplinary Sciences

The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease

D Chabas et al.

SCIENCE (2001)

Add to Collection

Article Clinical Neurology

Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences

C Bjartmar et al.

CURRENT OPINION IN NEUROLOGY (2001)

Add to Collection

Review Biochemistry & Molecular Biology

Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000)

LF Eng et al.

NEUROCHEMICAL RESEARCH (2000)

Add to Collection

Review Medicine, General & Internal

Medical progress: Multiple sclerosis.

JH Noseworthy et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.