4.7 Article

Changes in Metabotropic Glutamate Receptor Gene Expression in Rat Brain in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy

Related references

Note: Only part of the references are listed.
Article Neurosciences

G-alpha interacting protein interacting protein, C terminus 1 regulates epileptogenesis by increasing the expression of metabotropic glutamate receptor 7

Yong Liu et al.

Summary: The study identified that GIPC1 is downregulated in patients with epilepsy and mice with induced epilepsy, and it interacts with mGluR7 to regulate epileptogenesis by increasing mGluR7 expression.

CNS NEUROSCIENCE & THERAPEUTICS (2022)

Article Biochemistry & Molecular Biology

MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium-Pilocarpine Model of Epilepsy

Alexandra V. Dyomina et al.

Summary: In the study, treatment with the mGluR5 antagonist MTEP prevented neuronal loss and partially attenuated astrogliosis in a rat model of epilepsy, but did not prevent epilepsy occurrence or improve associated behavioral impairments. Despite its neuroprotective effects, MTEP treatment was ineffective in preventing epilepsy and alleviating behavioral comorbidities.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Behavioral Sciences

The pilocarpine model of mesial temporal lobe epilepsy: Over one decade later, with more rodent species and new investigative approaches

Maxime Levesque et al.

Summary: Research on the mechanisms of focal epileptic discharges in mesial temporal lobe epilepsy (MTLE) often utilizes rodent models induced by pilocarpine, revealing specific neuronal events during latent and chronic states, as well as the effects of optogenetic activation on spontaneous seizures.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

Review Biochemistry & Molecular Biology

Synaptic Dysfunction in Epilepsy

A. Zaitsev et al.

Summary: Epilepsy is a common cerebral disease characterized by reorganization of neural networks due to neuronal death and formation of new connections. Changes in the properties of chemical synapses during and after epileptic activity play a crucial role in the development and chronicity of epilepsy.

JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY (2021)

Review Neurosciences

Pharmacoresistance - Epidemiology, mechanisms, and impact on epilepsy treatment

Mubeen Janmohamed et al.

NEUROPHARMACOLOGY (2020)

Article Biochemical Research Methods

Multiplex qPCR assay for assessment of reference gene expression stability in rat tissues/samples

Alexander P. Schwarz et al.

MOLECULAR AND CELLULAR PROBES (2020)

Review Pharmacology & Pharmacy

Targeting metabotropic glutamate receptors in the treatment of epilepsy: rationale and current status

Roberta Celli et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2019)

Article Substance Abuse

Acute Ethanol Produces Ataxia and Induces Fmr1 Expression via Histone Modifications in the Rat Cerebellum

Russell S. Dulman et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2019)

Article Neurosciences

The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures

Benoit Girard et al.

NEUROBIOLOGY OF DISEASE (2019)

Review Biochemistry & Molecular Biology

On the Dependency of Cellular Protein Levels on mRNA Abundance

Yansheng Liu et al.

Article Multidisciplinary Sciences

Dynamic profiling of the protein life cycle in response to pathogens

Marko Jovanovic et al.

SCIENCE (2015)

Article Neurosciences

Enhanced NMDA receptor-dependent LTP in the epileptic CA1 area via upregulation of NR2B

Lorenz Mueller et al.

NEUROBIOLOGY OF DISEASE (2013)

Article Multidisciplinary Sciences

Different Emotional Disturbances in Two Experimental Models of Temporal Lobe Epilepsy in Rats

Marion Inostroza et al.

PLOS ONE (2012)

Article Neurosciences

Metabotropic glutamate receptors: From the workbench to the bedside

E. Nicoletti et al.

NEUROPHARMACOLOGY (2011)

Review Pharmacology & Pharmacy

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

Colleen M. Niswender et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2010)

Review Clinical Neurology

The descriptive epidemiology of epilepsy-A review

Poonam Nina Banerjee et al.

EPILEPSY RESEARCH (2009)

Article Neurosciences

Metabotropic glutamate receptor-dependent long-term potentiation

R. Anwyl

NEUROPHARMACOLOGY (2009)

Article Biochemistry & Molecular Biology

Selection of reference genes for quantitative real-time PCR in a rat asphyxial cardiac arrest model

Kristina Langnaese et al.

BMC MOLECULAR BIOLOGY (2008)

Review Biochemical Research Methods

The pilocarpine model of temporal lobe epilepsy

Giulia Curia et al.

JOURNAL OF NEUROSCIENCE METHODS (2008)

Article Neurosciences

Reference genes for normalization: A study of rat brain tissue

Birgit Egeskov Bonefeld et al.

SYNAPSE (2008)

Review Clinical Neurology

The neurobiology of epilepsy

Helen E. Scharfman

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2007)

Article Neurosciences

Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy

J. Pitsch et al.

NEUROBIOLOGY OF DISEASE (2007)

Review Clinical Neurology

Metabotropic glutamate receptors and epilepsy

Jorge Ure et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2006)

Article Biochemistry & Molecular Biology

Evaluation of various housekeeping genes for their applicability for normalization of mRNA expression in dioxin-treated rats

R Pohjanvirta et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2006)

Article Neurosciences

Taste receptor cells express pH-sensitive leak K+ channels

W Lin et al.

JOURNAL OF NEUROPHYSIOLOGY (2004)

Review Pharmacology & Pharmacy

Glutamate metabotropic receptors as targets for drug therapy in epilepsy

RX Moldrich et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2003)