Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/ijms23073733
Keywords
mitotic catastrophe; necroptosis; autophagy; doxorubicin treatment
Funding
- Russian Science Foundation [17-75-20102]
- Russian Foundation for Basic Research [20-015-00157]
- Swedish Cancer Society [190345]
- Stockholm Cancer Society [181301]
- Russian Science Foundation [17-75-20102] Funding Source: Russian Science Foundation
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Mitotic catastrophe is a defensive mechanism that promotes elimination of cells with aberrant mitosis by triggering cell death pathways. In certain conditions, mitotic catastrophe can precede necroptosis in addition to apoptosis and autophagy.
Mitotic catastrophe is a defensive mechanism that promotes elimination of cells with aberrant mitosis by triggering the cell-death pathways and/or cellular senescence. Nowadays, it is known that apoptosis, autophagic cell death, and necrosis could be consequences of mitotic catastrophe. Here, we demonstrate the ability of a DNA-damaging agent, doxorubicin, at 600 nM concentration to stimulate mitotic catastrophe. We observe that the inhibition of caspase activity leads to accumulation of cells with mitotic catastrophe hallmarks in which RIP1-dependent necroptotic cell death is triggered. The suppression of autophagy by a chemical inhibitor or ATG13 knockout upregulates RIP1 phosphorylation and promotes necroptotic cell death. Thus, in certain conditions mitotic catastrophe, in addition to apoptosis and autophagy, can precede necroptosis.
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