Journal
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
Volume 31, Issue 2, Pages -Publisher
WILEY
DOI: 10.1002/mpr.1910
Keywords
bias; depression; diagnostic test accuracy; sample size; screening
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This study assessed the sample size calculations, confidence intervals, and precision of recently published depression screening tool accuracy studies. The findings indicate that there is a lack of sample size calculations and most studies have small sample sizes, resulting in imprecise accuracy estimates.
Objectives Depression screening tool accuracy studies should be conducted with large enough sample sizes to generate precise accuracy estimates. We assessed the proportion of recently published depression screening tool diagnostic accuracy studies that reported sample size calculations; the proportion that provided confidence intervals (CIs); and precision, based on the width and lower bounds of 95% CIs for sensitivity and specificity. In addition, we assessed whether these results have improved since a previous review of studies published in 2013-2015. Methods MEDLINE was searched from January 1, 2018, through May 21, 2021. Results Twelve of 106 primary studies (11%) described a viable sample size calculation, which represented an improvement of 8% since the last review. Thirty-six studies (34%) provided reasonably accurate CIs. Of 103 studies where 95% CIs were provided or could be calculated, seven (7%) had sensitivity CI widths of <= 10%, whereas 58 (56%) had widths of >= 21%. Eighty-four studies (82%) had lower bounds of CIs <80% for sensitivity and 77 studies (75%) for specificity. These results were similar to those reported previously. Conclusion Few studies reported sample size calculations, and the number of included individuals in most studies was too small to generate reasonably precise accuracy estimates.
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