Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 64, Issue 34, Pages 6630-6640Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.6b02656
Keywords
bisphenol S; oxidative stress; catalase; hepatocyte; renal cell; spectroscopy
Funding
- NSFC [21277081, 21477067, 21507071, 201577083]
- Cultivation Fund of the Key Scientific and Technical Innovation Project
- Research Fund for the Doctoral Program of Higher Education and Ministry of Education of China [20130131110016]
- Science and Technology Development Plan of Shandong Province [2014GSF117027]
- Fundamental Research Funds of Shandong University [2014BT013, 2015JC010, 2015JC030]
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Bisphenol S (BPS) is present in multitudinous consumer products and detected in both food and water. It also has been a main substitute for bisphenol A (BPA) in the food-packaging industry. Yet, the toxicity of BPS is not fully understood. The present study of the toxicity of BPS was divided into two parts. First, oxidative stress, cell viability, apoptosis level, and catalase (CAT) activity in mouse hepatocytes and renal cells were investigated after BPS exposure. After 12 h of incubation with BPS, all of these parameters of hepatocytes and renal cells changed by >15% as the concentration of BPS ranged from 0.1 to 1 mM. Second, the direct interaction between BPS and CAT on the molecule level was investigated by multiple spectral methods and molecular docking investigations. BPS changed the structure and the activity of CAT through binding to the Gly 117 residue on the substrate channel of the enzyme. The main binding forces were hydrogen bond and hydrophobic force.
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