Journal
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Volume 117, Issue -, Pages 169-173Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2022.01.064
Keywords
COVID-19; Inactivated SARS-CoV-2 vaccine; S-RBD domain antibody; Immunogenicity; BMI
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This study explored the regularity of S-RBD domain antibody reactivity after immunization with inactivated SARS-CoV-2 vaccine and found that the vaccine had a good effect on the immune response. Age and sex did not affect the positive rate, while the positive rate was lower in the high BMI group.
Objectives: This study aimed to explore the regularity of S-RBD domain antibody reactivity after immunization with inactivated SARS-CoV-2 vaccine and evaluate the effect of this vaccine on the immune response. Design or methods: Venous blood samples were collected from 1156 healthcare workers who participated in the phase III clinical trial of the SARS-CoV-2 inactivated vaccine. The S-RBD domain antibody levels in the serum were detected by ELISA 14 days after the first and second active immunization, respectively. Results: The positive rates after inoculation of the first and second vaccination of S-RBD domain antibody against SARS-CoV-2 were 28.03% and 86.76%, respectively. The mean inhibition rate of S-RBD domain antibody against positive samples was 57.18 +/- 18.87% after the second vaccination at 14 days. Sex and age had no effects on the positive rate. The positive rate was decreased in the high BMI group. Single factor logistic analysis showed that there was no significant correlation between age and positive rate. BMI was negatively correlated with the positive rate. Conclusions: After 2 immunizations, the positive rate of SARS-CoV-2 S-RBD domain antibody was high, and the vaccine had good immunogenicity. The improvement of the immune strategy should focus on the effects of BMI and other factors. (c) 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
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