Journal
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Volume 116, Issue -, Pages 230-237Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2022.01.033
Keywords
Lyme Disease; Post-Treatment Lyme Disease; Symptom Measurement
Categories
Funding
- Steven and Alexandra Cohen Foundation
- Global Lyme Alliance (GLA)
- Bay Area Lyme Foundation (BALF)
- National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) [UL1 TR003098]
- NIH Roadmap for Medical Research
- Johns Hopkins Clinical Research Network (JHCRN)
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Participants with a history of Lyme disease are more likely to meet criteria for post-treatment Lyme disease (PTLD) and report more symptoms compared to those without a history of Lyme disease. Females and individuals with higher exposure to traumatic life events are also at an increased risk of meeting PTLD criteria.
Purpose: Post-treatment Lyme disease (PTLD) is characterized by patient-reported symptoms after treatment for Borrelia burgdorferi infection. The primary aim of this study was to assess whether participants with a history of Lyme disease (LD) would be more likely to meet criteria for PTLD than those without a history of LD. Methods: We conducted a longitudinal, prospective study among 234 participants with and 49 participants without prior LD. All completed survey metrics for fatigue, pain, sleep, depression, and quality of life. An operationalized PTLD definition was applied to both cohorts, and the distributions of clinical outcomes and symptoms were examined. Results: In total, 13 middot7% of participants with a history of prior LD met criteria for PTLD compared with 4.1% of those without a history of prior LD. Participants with prior LD were approximately 5.28 times as likely to meet PTLD criteria compared with those without prior LD (p = 0.042) and had 8-15 times as high odds of reporting moderate or severe fatigue and muscle pain (p = 0.002, 0.047, respectively). Risk of meeting PTLD criteria was also independently increased among females and those with higher exposure to previous traumatic life events. Conclusion: Participants ideally diagnosed and treated for prior LD reported more symptoms on stan-dardized surveys and were more likely to meet criteria for PTLD than those without prior LD. (C) 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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