Prognostic factors of Pasteurella infections: a single-center retrospective cohort study over a 14-year period (2005-2018)

Background: Pasteurella spp. can lead to fatal infections in humans. Objective: To assess prognostic factors of invasive pasteurellosis. Methods: We conducted a single retrospective cohort study of local versus invasive Pasteurella infections from January 1, 2005, to December 31, 2018, in the Amiens-Picardie University Hospital, France. Results: Forty-five (20.9%) invasive pasteurellosis and 22 (10.2%) complicated local infections were reported among a total of 215 Pasteurella infections. The mortality rate among invasive infections was 22.2% (10/ 45) whereas no death was recorded in local infections group. Non-drug-induced prothrombin time test < 70% of standard and platelet counts < 10 0,0 0 0/mm(3) were more frequent in non-survivors than in survivors (p = 0.005 and p = 0.019) in univariate analyses. A history of neoplasia (adjusted OR = 13.62, p = 0.020), an evidence of bacteremia (adjusted OR = 20.68, p = 0.025), and hemoglobin level < 10 g/dL (adjusted OR = 17.80, p = 0.028) were identified as poor prognostic factors in multivariate analyses. Conclusion: Invasive pasteurellosis appears as a serious disease in vulnerable patients, particularly if bacteremia and/or coagulopathies occur. (C) 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

Automated summary

This study aimed to assess prognostic factors of invasive pasteurellosis. A retrospective cohort study found that abnormal coagulation function (prolonged prothrombin time) and low platelet counts were common factors in non-survivors. Furthermore, a history of neoplasia, evidence of bacteremia, and low hemoglobin level were identified as poor prognostic factors.