Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 64, Issue 7, Pages 1509-1519Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.5b04924
Keywords
walnut peptides-zinc complex; biosynthesis; antitumor; apoptosis
Funding
- Guangdong Natural Science Funds for Distinguished Young Scholars [S2013050013954]
- Program for New Century Excellent Talents in University [NCET-13-0213]
- Guangdong Province Funded Research Projects [2013B010404001]
- Key Laboratory of Aquatic Product Processing, Ministry of Agriculture, P.R China [NYJG201402]
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The walnut peptides and zinc ions were combined to generate a walnut peptides-zinc complex (WP1-Zn) with enhanced antiproliferative ability as well as reduced toxicity. The result indicated that Zn ions were successfully combined with WP1 through Zn-N and Zn-O covalent bonds. WP1-Zn compounds exhibited strong antiproliferative ability against the selected human cell lines, especially MCF-7 cells, whose survival rate reduced to 20.02% after exposure to 300 mu g/mL of WP1-Zn for 48 h. WP1-Zn inhibited MCF-7 cell proliferation through inducing cell apoptosis and cell cycle arrest. The results indicated that WP1-Zn induced MCF-7 cell apoptosis via the ROS triggered mitochondrial-mediated pathway and cell surface receptor mediated pathway. Our work is the first attempt to elucidate the synergic effect of novel walnut peptides and Zn and with the hope of better understanding the antiproliferative action of bioactive peptides and a zinc complex and support the potential application of WP1-Zn as a functional food ingredient or complementary medicine.
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