What is new in adult acne for the last 2 years: focus on acne pathophysiology and treatments

Acne affects more than 640 million people worldwide, including about 85% of adolescents. This inflammatory dermatosis affects the entire population, from teenagers to adults, which reinforces the need to investigate it. Furthermore, in adults, acne has serious consequences, including a psychological impact, low self-esteem, social isolation, and depression. Over the last years, the understanding of acne pathophysiology has improved, mainly thanks to the identification of the pivotal role of the microbiota. The aim of this review was to screen the most recent scientific literature on adult acne and the newly tested treatments. Clinically, therapeutic innovations for the treatment of acne have been recently developed, including pre/probiotics, new molecules, and innovative formulations associated, however, with fewer side effects. Moreover, clinical trials are underway to use off-label molecules that seem to be proving their value in the fight against adult acne.

Automated summary

Acne is a common global disease that affects a large proportion of the population, especially adolescents. It not only has physical implications but also serious psychological consequences in adults. Recent advancements in understanding the role of the microbiota have improved our understanding of acne pathophysiology. Clinically, new therapeutic options including pre/probiotics, new molecules, and innovative formulations with fewer side effects have been developed. Additionally, promising off-label molecules are being tested for the treatment of adult acne.