4.7 Article

CD8 agonism functionally activates memory T cells and enhances antitumor immunity

Related references

Note: Only part of the references are listed.
Review Immunology

Next generation immunotherapy: enhancing stemness of polyclonal T cells to improve anti-tumor activity

Rigel J. Kishton et al.

Summary: The administration of T cells as cellular therapy has shown clinical benefit in cancer patients. However, these therapies are not curative for most patients, especially those with solid tumors. Recent research has focused on understanding key factors that regulate the efficacy of T cell therapy and developing strategies to improve clinical outcomes in solid tumors.

CURRENT OPINION IN IMMUNOLOGY (2022)

Article Immunology

TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion

Mojdeh Shakiba et al.

Summary: TCR signal strength plays a critical role in T cell differentiation and function in tumors, with high signal strength leading to dysfunction and low signal strength resulting in functional inertness. Fine-tuning signal strength to an intermediate range can improve anti-tumor activity.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Multidisciplinary Sciences

An engineered IL-2 partial agonist promotes CD8+ T cell stemness

Fei Mo et al.

Summary: Adoptive transfer of antigen-specific T cells is a significant advancement in cancer immunotherapy, and maintaining a stem-cell-like state before transfer is beneficial for therapeutic efficacy.

NATURE (2021)

Review Immunology

CD8+ T cell metabolism in infection and cancer

Miguel Reina-Campos et al.

Summary: CD8(+) T cells play a crucial role in eliminating intracellular infections and malignant cells, with their metabolism being influenced by extracellular metabolites and immunological signals. Both intrinsic and extrinsic metabolic cues can contribute to CD8(+) T cell dysfunction, and overall host metabolism can also impact the CD8(+) T cell response.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection

Ioana Sandu et al.

NATURE COMMUNICATIONS (2020)

Article Cell Biology

Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans

Franziska M. Uhl et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Article Endocrinology & Metabolism

Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy

Ramon I. Klein Geltink et al.

NATURE METABOLISM (2020)

Article Multidisciplinary Sciences

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

Robert D. Leone et al.

SCIENCE (2019)

Article Biochemical Research Methods

DExSI: a new tool for the rapid quantitation of 13C-labelled metabolites detected by GC-MS

Michael J. Dagley et al.

BIOINFORMATICS (2018)

Article Biochemistry & Molecular Biology

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

Marc O. Johnson et al.

Article Biochemistry & Molecular Biology

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

Moshe Sade-Feldman et al.

Article Biotechnology & Applied Microbiology

SCANPY: large-scale single-cell gene expression data analysis

F. Alexander Wolf et al.

GENOME BIOLOGY (2018)

Article Multidisciplinary Sciences

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Se Jin Im et al.

NATURE (2016)

Article Multidisciplinary Sciences

Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells

Lenka V. Hurton et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Cell Biology

Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity

Dane M. Newman et al.

CELL REPORTS (2016)

Article Biochemistry & Molecular Biology

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

Chih-Hao Chang et al.

Review Oncology

Paths to stemness: building the ultimate antitumour T cell

Luca Gattinoni et al.

NATURE REVIEWS CANCER (2012)

Article Multidisciplinary Sciences

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

Erika L. Pearce et al.

NATURE (2009)

Article Multidisciplinary Sciences

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T Cells

CA Klebanoff et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Immunology

Lineage relationship and protective immunity of memory CD8 T cell subsets

EJ Wherry et al.

NATURE IMMUNOLOGY (2003)