Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 209, Issue -, Pages 1593-1604Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.04.029
Keywords
Poria cocos polysaccharide; Chronic nonbacterial prostatitis; Sex hormone
Funding
- National Natural Science Funds of China [32072223]
- Key-Area Research and Development Program of Guangdong Province [2020B020226008]
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This study found that Poria cocos polysaccharides (PPs) alleviate chronic nonbacterial prostatitis (CNP) by affecting the gut bacteria. Parabacteroides, Fusicatenibacter, and Parasutterella were identified as important bacteria in CNP alleviation, and their metabolites, such as 7-ketodeoxycholic acid and haloperidol glucuronide, were the signal molecules of the gut-prostate axis.
Chronic nonbacterial prostatitis (CNP) is a common urology disease. Our previous research found Poria cocos polysaccharides (PPs) alleviated CNP and suggested the effect was related to gut bacteria. We investigated the crucial bacteria and their metabolites responsible for the anti-CNP effect to discover possible mechanisms. The results showed that after the fermentation of PPs by human fecal microbiota, Parabacteroides, Fusicatenibacter, and Parasutterella were significantly enriched. Haloperidol glucuronide and 7-ketodeoxycholic acid generated by these bacteria could be responsible for the increased expression of Alox15 and Pla2g2f and the reduced expression of Cyp1a1 and Hsd17b7 in colon epithelium. The ratio of dihydrotestosterone to estradiol in serum was regulated, and CNP was alleviated. Our results suggested that Parabacteroides, Fusicatenibacter, and Parasutterella could be the essential bacteria in CNP alleviation and their metabolites of PPs 7-ketodeoxycholic acid and haloperidol glucuronide could be the signal molecules of the gut-prostate axis.
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