Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 213, Issue -, Pages 923-933Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.05.179
Keywords
Curcumin; Polyelectrolyte nanoparticles; Encapsulation
Funding
- National Natural Science Foundation of China [31671812, 31901682]
- National Key Research and Development Program of China [2016YFD0400203]
- Foundation for Innovation Team in Higher Education of Guangdong, China [2021KCXTD035]
- Institute of Science and Technology Innovation, DGUT [KCYCXPT2017007]
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This study successfully developed a new method for encapsulating curcumin using polyelectrolyte nanoparticles. Compared with free curcumin, curcumin loaded in the nanoparticles demonstrated improved performance, including better redispersion, thermal stability, photostability, and sustained release.
In this study, carboxylic curdlan (Cur-48) and negatively charged ferulic acid (FA)-grafted carboxylic curdlan (Cur 48 g FA) were separately used to fabricate polyelectrolyte nanoparticles (PNPs: PNPs-CQ and PNPs-CFQ) with positively charged quaternized curdlan (Qcurd) for curcumin delivery. Results showed that curcumin-loaded PNPs-CQ and PNPs-CFQ had particle sizes of 338.1 and 301.3 nm, zeta potentials of -19.07 and -24.10 mV, and encapsulation efficiencies of 76.32% and 83.54%, respectively. Curcumin was properly encapsulated inside the two PNPs through electrostatic interactions and hydrogen bonds. Compared with free curcumin, entrapped curcumin in the two PNPs exhibited better redispersion performance, thermo- and photostability, and sustained release property. Furthermore, FA molecules surrounding the surface of PNPs-CFQ were conductive to the entrapped curcumin's particulate characteristics, stability, release behavior, and antioxidant potentials. Therefore, our findings indicated that PNPs formulated via Cur-48-g-FA and Qcurd can provide a novel delivery platform for encapsulation of hydrophobic nutrients, including curcumin, in functional foods.
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