Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 209, Issue -, Pages 2197-2212Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.04.201
Keywords
Gums; Carboxymethylation; Drug delivery; Tissue engineering; Degree of substitution
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This review discusses the properties and issues of natural gums, as well as the research and applications of carboxymethylation. The article provides detailed information on the application of carboxymethyl gums as drug delivery carriers and briefly introduces their potential in tissue engineering and cell delivery.
Diverse properties of natural gums have made them quite useful for various pharmaceutical applications. However, they suffer from various problems, including unregulated hydration rates, microbial degradation, and decline in viscosity during warehousing. Among various chemical procedures for modification of gums, carboxymethylation has been widely studied due to its simplicity and efficiency. Despite the availability of numerous research articles on natural gums and their uses, a comprehensive review on carboxymethylation of natural gums and their applications in the pharmaceutical and other biomedical fields is not published until now. This review outlines the classification of gums and their derivatization methods. Further, we have discussed various techniques of carboxymethylation, process of determination of degree of substitution, and functionalization pattern of substituted gums. Detailed information about the application of carboxymethyl gums as drug delivery carriers has been described. The article also gives a brief account on tissue engineering and cell delivery potential of carboxymethylated gums.
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